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We investigate how locomotory behavior is generated in the brain focusing on the paradigmatic connectome of nematode Caenorhabditis elegans (C. elegans) and on neuronal activity patterns that control forward locomotion. We map the neuronal…

Adaptation and Self-Organizing Systems · Physics 2020-06-17 Thomas Maertens , Eckehard Schöll , Jorge Ruiz , Philipp Hövel

Despite the relative simplicity of C. elegans, its locomotion machinery is not yet well understood. We focus on the generation of dorsoventral body bends. While central pattern generators are commonly involved in animal locomotion, their…

Neurons and Cognition · Quantitative Biology 2017-11-08 Erick Olivares , Eduardo J. Izquierdo , Randall D. Beer

Post-genomic research deals with challenging problems in screening genomes of organisms for particular functions or potential for being the targets of genetic engineering for desirable biological features. 'Phenotyping' of wild type and…

Quantitative Methods · Quantitative Biology 2010-09-06 Hesam T. Dashti , Jernej Tonejc , Adel Ardalan , Alireza F. Siahpirani , Sabrina Guettes , Zohreh Sharif , Liya Wang , Amir H. Assadi

The transport of bio-particles in viscous flows exhibits a rich variety of dynamical behaviour, such as morphological transitions, complex orientation dynamics or deformations. Characterising such complex behaviour under well controlled…

How microorganisms respond to and interact with their environment can vary significantly from individual to individual, which can have important microbiological and ecological implications. However, most microscopy techniques can only…

3D cell tracking in a living organism has a crucial role in live cell image analysis. Cell tracking in C. elegans has two difficulties. First, cell migration in a consecutive frame is large since they move their head during scanning.…

Computer Vision and Pattern Recognition · Computer Science 2024-03-21 Kaito Shiku , Hiromitsu Shirai , Takeshi Ishihara , Ryoma Bise

The motility of the worm nematode \textit{Caenorhabditis elegans} is investigated in shallow, wet granular media as a function of particle size dispersity and area density ($\phi$). Surprisingly, we find that the nematode's propulsion speed…

Biological Physics · Physics 2012-03-06 G. Juarez , K. Lu , J. Sznitman , P. E. Arratia

Animal habitat surveys play a critical role in preserving the biodiversity of the land. One of the effective ways to gain insights into animal habitats involves identifying animal footprints, which offers valuable information about species…

Computer Vision and Pattern Recognition · Computer Science 2024-06-17 Risa Shinoda , Kaede Shiohara

Objects we encounter often change appearance as we interact with them. Changes in illumination (shadows), object pose, or the movement of non-rigid objects can drastically alter available image features. How do biological visual systems…

Artificial Intelligence · Computer Science 2025-03-04 Sabine Muzellec , Drew Linsley , Alekh K. Ashok , Ennio Mingolla , Girik Malik , Rufin VanRullen , Thomas Serre

Tracking many cells in time-lapse 3D image sequences is an important challenging task of bioimage informatics. Motivated by a study of brain-wide 4D imaging of neural activity in C. elegans, we present a new method of multi-cell tracking.…

Computer Vision and Pattern Recognition · Computer Science 2018-01-18 Osamu Hirose , Shotaro Kawaguchi , Terumasa Tokunaga , Yu Toyoshima , Takayuki Teramoto , Sayuri Kuge , Takeshi Ishihara , Yuichi Iino , Ryo Yoshida

The millimeter-long soil-dwelling nematode {\it C. elegans} propels itself by producing undulations that propagate along its body and turns by assuming highly curved shapes. According to our recent study [PLoS ONE \textbf{7}, e40121 (2012)]…

Fluid Dynamics · Physics 2019-01-18 Alejandro Bilbao , Eligiusz Wajnryb , Siva Vanapalli , Jerzy Blawzdziewicz

Today, the area of point-of-care diagnostics is synonymous with paper microfluidics where cheap, disposable, and on-the-spot detection toolkits are being developed for a variety of chemical tests. In this work, we present a novel…

Image and Video Processing · Electrical Eng. & Systems 2022-06-24 Zach Njus , Taejoon Kong , Upender Kalwa , Christopher Legner , Matthew Weinstein , Shawn Flanigan , Jenifer Saldanha , Santosh Pandey

Particle tracking is a powerful biophysical tool that requires conversion of large video files into position time series, i.e. traces of the species of interest for data analysis. Current tracking methods, based on a limited set of input…

Quantitative Methods · Quantitative Biology 2018-10-09 Jay M. Newby , Alison M. Schaefer , Phoebe T. Lee , M. Gregory Forest , Samuel K. Lai

Animal locomotion is often subject to constraints arising from anatomical/physiological asymmetries. We use the nematode C.~elegans as a minimal model system to ask whether such constraints might shape locomotion patterns optimized during…

Neurons and Cognition · Quantitative Biology 2024-01-17 W. Mathijs Rozemuller , Steffen Werner , Antonio Carlos Costa , Liam O'Shaughnessy , Greg J. Stephens , Thomas S. Shimizu

Field-captured video facilitates detailed studies of spatio-temporal aspects of animal locomotion, decision-making and environmental interactions including predator-prey relationships and habitat utilisation. But even though data capture is…

Computer Vision and Pattern Recognition · Computer Science 2024-10-03 Malika Nisal Ratnayake , Lex Gallon , Adel N. Toosi , Alan Dorin

We develop a stochastic whole-brain and body simulator of the nematode roundworm Caenorhabditis elegans (C. elegans) and show that it is sufficiently regularizing to allow imputation of latent membrane potentials from partial calcium…

Neurons and Cognition · Quantitative Biology 2019-07-26 Andrew Warrington , Arthur Spencer , Frank Wood

We exploit the reduced space of C. elegans postures to develop a novel tracking algorithm which captures both simple shapes and also self-occluding coils, an important, yet unexplored, component of worm behavior. We apply our algorithm to…

Quantitative Methods · Quantitative Biology 2016-11-01 Onno D Broekmans , Jarlath B Rodgers , William S Ryu , Greg J Stephens

Studies of social and group behavior in interacting organisms require high-throughput analysis of the motion of a large number of individual subjects. Computer vision techniques offer solutions to specific tracking problems, and allow…

Quantitative Methods · Quantitative Biology 2015-06-12 Yi Deng , Philip Coen , Mingzhai Sun , Joshua W. Shaevitz

Computational approaches which emulate in-vivo nervous system are needed to investigate mechanisms of the brain to orchestrate behavior. Such approaches must integrate a series of biophysical models encompassing the nervous system, muscles,…

Quantitative Methods · Quantitative Biology 2025-06-05 Jimin Kim , Jeremy T. Florman , Julia A. Santos , Mark J. Alkema , Eli Shlizerman

We present a new approach for understanding the periodicity structure and semantics of motion datasets, independently of the morphology and skeletal structure of characters. Unlike existing methods using an overly sparse high-dimensional…

Computer Vision and Pattern Recognition · Computer Science 2024-07-30 Peizhuo Li , Sebastian Starke , Yuting Ye , Olga Sorkine-Hornung