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Many state-of-the-art machine learning models such as deep neural networks have recently shown to be vulnerable to adversarial perturbations, especially in classification tasks. Motivated by adversarial machine learning, in this paper we…

Machine Learning · Statistics 2018-10-04 Pin-Yu Chen , Bhanukiran Vinzamuri , Sijia Liu

Modern technologies are producing a wealth of data with complex structures. For instance, in two-dimensional digital imaging, flow cytometry, and electroencephalography, matrix type covariates frequently arise when measurements are obtained…

Methodology · Statistics 2013-10-22 Hua Zhou , Lexin Li

Multiple sclerosis (MS) is a chronic autoimmune disease that affects the central nervous system. The progression and severity of MS varies by individual, but it is generally a disabling disease. Although medications have been developed to…

Applications · Statistics 2013-03-06 Joyce C. Ho , Joydeep Ghosh , KP Unnikrishnan

With the growing imbalance between limited medical resources and escalating demands, AI-based clinical tasks have become paramount. As a sub-domain, medication recommendation aims to amalgamate longitudinal patient history with medical…

Artificial Intelligence · Computer Science 2023-11-28 Xiang Li , Shunpan Liang , Yulei Hou , Tengfei Ma

Electronic Medical Records (EHR) are extremely sparse. Only a small proportion of events (symptoms, diagnoses, and treatments) are observed in the lifetime of an individual. The high degree of missingness of EHR can be attributed to a large…

Artificial Intelligence · Computer Science 2021-11-18 Ramon Vinas , Xu Zheng , Jer Hayes

Analysis of longitudinal Electronic Health Record (EHR) data is an important goal for precision medicine. Difficulty in applying Machine Learning (ML) methods, either predictive or unsupervised, stems in part from the heterogeneity and…

Quantitative Methods · Quantitative Biology 2022-04-18 Alan D. Kaplan , Uttara Tipnis , Jean C. Beckham , Nathan A. Kimbrel , David W. Oslin , Benjamin H. McMahon

Severity level estimation is a crucial task in medical image diagnosis. However, accurately assigning severity class labels to individual images is very costly and challenging. Consequently, the attached labels tend to be noisy. In this…

Computer Vision and Pattern Recognition · Computer Science 2024-10-30 Shumpei Takezaki , Kiyohito Tanaka , Seiichi Uchida

This paper extends the class of ordinal regression models with a structured interpretation of the problem by applying a novel treatment of encoded labels. The net effect of this is to transform the underlying problem from an ordinal…

Machine Learning · Computer Science 2019-06-03 Niall Twomey , Rafael Poyiadzi , Callum Mann , Raúl Santos-Rodríguez

Motivated by cutting-edge applications like cryo-electron microscopy (cryo-EM), the Multi-Reference Alignment (MRA) model entails the learning of an unknown signal from repeated measurements of its images under the latent action of a group…

Statistics Theory · Mathematics 2022-03-11 Subhro Ghosh , Philippe Rigollet

Decentralized sparsity learning has attracted a significant amount of attention recently due to its rapidly growing applications. To obtain the robust and sparse estimators, a natural idea is to adopt the non-smooth median loss combined…

Machine Learning · Statistics 2022-03-02 Weidong Liu , Xiaojun Mao , Xin Zhang

The utilization of Electronic Health Records (EHRs) for clinical risk prediction is on the rise. However, strict privacy regulations limit access to comprehensive health records, making it challenging to apply standard machine learning…

Computation and Language · Computer Science 2023-12-08 Angeela Acharya , Sulabh Shrestha , Anyi Chen , Joseph Conte , Sanja Avramovic , Siddhartha Sikdar , Antonios Anastasopoulos , Sanmay Das

Motivated by the problem of determining the atomic structure of macromolecules using single-particle cryo-electron microscopy (cryo-EM), we study the sample and computational complexities of the sparse multi-reference alignment (MRA) model:…

Information Theory · Computer Science 2021-09-27 Tamir Bendory , Oscar Mickelin , Amit Singer

Sparse covariates are frequent in classification and regression problems and in these settings the task of variable selection is usually of interest. As it is well known, sparse statistical models correspond to situations where there are…

Methodology · Statistics 2020-02-14 Ana M. Bianco , Graciela Boente , Gonzalo Chebi

Neuroimage analysis usually involves learning thousands or even millions of variables using only a limited number of samples. In this regard, sparse models, e.g. the lasso, are applied to select the optimal features and achieve high…

Machine Learning · Computer Science 2015-03-26 Bo Xin , Lingjing Hu , Yizhou Wang , Wen Gao

Over the last century, risk scores have been the most popular form of predictive model used in healthcare and criminal justice. Risk scores are sparse linear models with integer coefficients; often these models can be memorized or placed on…

Machine Learning · Computer Science 2022-10-13 Jiachang Liu , Chudi Zhong , Boxuan Li , Margo Seltzer , Cynthia Rudin

The healthcare sector has experienced a rapid accumulation of digital data recently, especially in the form of electronic health records (EHRs). EHRs constitute a precious resource that IS researchers could utilize for clinical applications…

Machine Learning · Computer Science 2024-11-06 Thiti Suttaket , L Vivek Harsha Vardhan , Stanley Kok

Electronic Health Record (EHR) data can be represented as discrete counts over a high dimensional set of possible procedures, diagnoses, and medications. Supervised topic models present an attractive option for incorporating EHR data as…

Machine Learning · Computer Science 2019-11-21 Jason Ren , Russell Kunes , Finale Doshi-Velez

In this paper we propose a multivariate ordinal regression model which allows the joint modeling of three-dimensional panel data containing both repeated and multiple measurements for a collection of subjects. This is achieved by a…

Methodology · Statistics 2024-02-02 Laura Vana-Gür

Most classification methods provide either a prediction of class membership or an assessment of class membership probability. In the case of two-group classification the predicted probability can be described as "risk" of belonging to a…

Machine Learning · Statistics 2011-10-28 Yizhar Toren

Scalable and accurate identification of specific clinical outcomes has been enabled by machine-learning applied to electronic medical record (EMR) systems. The development of classification models requires the collection of a complete…

Methodology · Statistics 2020-11-09 W. Katherine Tan , Patrick J. Heagerty