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Functional connectivity fingerprints are among today's best choices to obtain a faithful sampling of an individual's brain and cognition in health and disease. Here we make a case for key advantages of analyzing such connectome profiles…

Methodology · Statistics 2019-09-06 Danilo Bzdok , Dorothea L. Floris , Andre F. Marquand

Statistical hypothesis testing, as formalized by 20th Century statisticians and taught in college statistics courses, has been a cornerstone of 100 years of scientific progress. Nevertheless, the methodology is increasingly questioned in…

Methodology · Statistics 2024-08-22 Brian Dennis , Mark L Taper , José M Ponciano

Comparative graph and network analysis play an important role in both systems biology and pattern recognition, but existing surveys on the topic have historically ignored or underserved one or the other of these fields. We present an…

Social and Information Networks · Computer Science 2019-05-17 Emily Evans , Marissa Graham

Functional and effective networks inferred from time series are at the core of network neuroscience. Interpreting their properties requires inferred network models to reflect key underlying structural features; however, even a few spurious…

Neurons and Cognition · Quantitative Biology 2022-09-22 Leonardo Novelli , Joseph T. Lizier

In increasingly many settings, data sets consist of multiple samples from a population of networks, with vertices aligned across these networks. For example, brain connectivity networks in neuroscience consist of measures of interaction…

Statistics Theory · Mathematics 2021-05-11 Keith Levin , Asad Lodhia , Elizaveta Levina

Rejecting the null hypothesis in two-sample testing is a fundamental tool for scientific discovery. Yet, aside from concluding that two samples do not come from the same probability distribution, it is often of interest to characterize how…

Statistics Theory · Mathematics 2021-09-08 Boris Landa , Rihao Qu , Joseph Chang , Yuval Kluger

As the field of neuroimaging grows, it can be difficult for scientists within the field to gain and maintain a detailed understanding of its ever-changing landscape. While collaboration and citation networks highlight important…

Social and Information Networks · Computer Science 2019-01-24 Jordan D. Dworkin , Russell T. Shinohara , Danielle S. Bassett

Networks are ubiquitous in science and have become a focal point for discussion in everyday life. Formal statistical models for the analysis of network data have emerged as a major topic of interest in diverse areas of study, and most of…

Methodology · Statistics 2009-12-31 Anna Goldenberg , Alice X Zheng , Stephen E Fienberg , Edoardo M Airoldi

Understanding the operation of biological and artificial networks remains a difficult and important challenge. To identify general principles, researchers are increasingly interested in surveying large collections of networks that are…

Machine Learning · Statistics 2022-01-14 Alex H. Williams , Erin Kunz , Simon Kornblith , Scott W. Linderman

Virtually all network analyses involve structural measures between pairs of vertices, or of the vertices themselves, and the large amount of symmetry present in real-world complex networks is inherited by such measures. This has practical…

Combinatorics · Mathematics 2020-08-05 Rubén J. Sánchez-García

Many complex systems - be they financial, natural, or social - are composed of units - such as stocks, neurons, or agents - whose joint activity can be represented as a multivariate time series. An issue of both practical and theoretical…

Almost all statistical and machine learning methods in analyzing brain networks rely on distances and loss functions, which are mostly Euclidean or matrix norms. The Euclidean or matrix distances may fail to capture underlying subtle…

Computational Geometry · Computer Science 2021-02-18 Moo K. Chung , Alexander Smith , Gary Shiu

Reaching a global view of brain organization requires assembling evidence on widely different mental processes and mechanisms. The variety of human neuroscience concepts and terminology poses a fundamental challenge to relating brain…

Quantitative Methods · Quantitative Biology 2020-02-24 Jérôme Dockès , Russell Poldrack , Romain Primet , Hande Gözükan , Tal Yarkoni , Fabian Suchanek , Bertrand Thirion , Gaël Varoquaux

Sustainable research on computational models of neuronal networks requires published models to be understandable, reproducible, and extendable. Missing details or ambiguities about mathematical concepts and assumptions, algorithmic…

Although social neuroscience is concerned with understanding how the brain interacts with its social environment, prevailing research in the field has primarily considered the human brain in isolation, deprived of its rich social context.…

Social and Information Networks · Computer Science 2020-02-13 Elisa C. Baek , Mason A. Porter , Carolyn Parkinson

Understanding the human brain remains the Holy Grail in biomedical science, and arguably in all of the sciences. Our brains represent the most complex systems in the world (and some contend the universe) comprising nearly one hundred…

Quantitative Methods · Quantitative Biology 2016-02-03 Sean L. Simpson , Paul J. Laurienti

The inference of network topologies from relational data is an important problem in data analysis. Exemplary applications include the reconstruction of social ties from data on human interactions, the inference of gene co-expression…

Social and Information Networks · Computer Science 2021-02-24 Giona Casiraghi , Vahan Nanumyan , Ingo Scholtes , Frank Schweitzer

The recent success of generative adversarial networks and variational learning suggests training a classifier network may work well in addressing the classical two-sample problem. Network-based tests have the computational advantage that…

Machine Learning · Statistics 2022-06-01 Xiuyuan Cheng , Alexander Cloninger

One of the most challenging tasks when adopting Bayesian Networks (BNs) is the one of learning their structure from data. This task is complicated by the huge search space of possible solutions, and by the fact that the problem is NP-hard.…

Machine Learning · Computer Science 2018-08-07 Stefano Beretta , Mauro Castelli , Ivo Goncalves , Roberto Henriques , Daniele Ramazzotti

This article presents a review of computational methods for connectivity inference from neural activity data derived from multi-electrode recordings or fluorescence imaging. We first identify biophysical and technical challenges in…

Neurons and Cognition · Quantitative Biology 2017-12-18 Ildefons Magrans de Abril , Junichiro Yoshimoto , Kenji Doya