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Accurate prediction of molecular properties in complex chemical systems is crucial for accelerating material discovery and chemical innovation. However, current computational methods often struggle to capture the intricate compositional…

Chemical Physics · Physics 2025-09-24 Jinming Fan , Chao Qian , Shaodong Zhou

Recommending event schedules is a key issue in Event-based Social Networks (EBSNs) in order to maintain user activity. An effective recommendation is required to maximize the user's preference, subjecting to both time and geographical…

Artificial Intelligence · Computer Science 2025-11-18 Yiming Zhao , Jiwei Tang , Shimin Di , Libin Zheng , Jianxing Yu , Jian Yin

Deep learning has the potential to revolutionize quantum chemistry as it is ideally suited to learn representations for structured data and speed up the exploration of chemical space. While convolutional neural networks have proven to be…

Contextual combinatorial optimization (CCO) plays a critical role in decision-making under uncertainty, yet remains a significant challenge. We present Quantum End-to-End Learning (QEL), the first quantum computing-based end-to-end learning…

Quantum Physics · Physics 2026-05-21 Jaehwan Lee , Changhyun Kwon

Graph transformation formalisms have proven to be suitable tools for the modelling of chemical reactions. They are well established in theoretical studies and increasingly also in practical applications in chemistry. The latter is made…

Discrete Mathematics · Computer Science 2022-08-29 Jakob L. Andersen , Rolf Fagerberg , Juri Kolčák , Christophe V. F. P. Laurent , Daniel Merkle , Nikolai Nøjgaard

The stochastic kinetics of BRN are described by a chemical master equation (CME) and the underlying laws of mass action. The CME must be usually solved numerically by generating enough traces of random reaction events. The resulting…

Molecular Networks · Quantitative Biology 2023-06-21 Pavel Loskot

Chemical reaction mechanisms are the foundation of how chemists evaluate reactivity and feasibility, yet current Computer-Assisted Synthesis Planning (CASP) systems operate without this mechanistic reasoning. We introduce a computational…

Machine Learning · Computer Science 2026-04-20 Théo A. Neukomm , Zlatko Jončev , Philippe Schwaller

Chemical large language models (LLMs) predominantly rely on explicit Chain-of-Thought (CoT) in natural language to perform complex reasoning. However, chemical reasoning is inherently continuous and structural, and forcing it into discrete…

Causal structure learning (CSL) refers to the task of learning causal relationships from data. Advances in CSL now allow learning of causal graphs in diverse application domains, which has the potential to facilitate data-driven causal…

Machine Learning · Statistics 2024-07-09 Luka Kovačević , Izzy Newsham , Sach Mukherjee , John Whittaker

Theoretical studies on chemical reaction mechanisms have been crucial in organic chemistry. Traditionally, calculating the manually constructed molecular conformations of transition states for chemical reactions using quantum chemical…

Chemical Physics · Physics 2024-04-12 Sihao Yuan , Xu Han , Jun Zhang , Zhaoxin Xie , Cheng Fan , Yunlong Xiao , Yi Qin Gao , Yi Isaac Yang

Predicting and enhancing inherent properties based on molecular structures is paramount to design tasks in medicine, materials science, and environmental management. Most of the current machine learning and deep learning approaches have…

Machine Learning · Computer Science 2024-04-08 Zachary R. Fox , Ayana Ghosh

Molecular structures are always depicted as 2D printed form in scientific documents like journal papers and patents. However, these 2D depictions are not machine-readable. Due to a backlog of decades and an increasing amount of these…

Computer Vision and Pattern Recognition · Computer Science 2022-05-24 Youjun Xu , Jinchuan Xiao , Chia-Han Chou , Jianhang Zhang , Jintao Zhu , Qiwan Hu , Hemin Li , Ningsheng Han , Bingyu Liu , Shuaipeng Zhang , Jinyu Han , Zhen Zhang , Shuhao Zhang , Weilin Zhang , Luhua Lai , Jianfeng Pei

Learning a kernel matrix from relative comparison human feedback is an important problem with applications in collaborative filtering, object retrieval, and search. For learning a kernel over a large number of objects, existing methods face…

Machine Learning · Computer Science 2015-01-13 Eric Heim , Matthew Berger , Lee M. Seversky , Milos Hauskrecht

The demand of finite raw materials will keep increasing as they fuel modern society. Simultaneously, solutions for stopping carbon emissions in the short term are not available, thus making the net zero target extremely challenging to…

Computers and Society · Computer Science 2025-12-17 Federico Zocco , Andrea Corti , Monica Malvezzi

Fast and accurate simulation of complex chemical systems in environments such as solutions is a long standing challenge in theoretical chemistry. In recent years, machine learning has extended the boundaries of quantum chemistry by…

Chemical Physics · Physics 2020-11-05 Michael Gastegger , Kristof T. Schütt , Klaus-Robert Müller

Entity Linking is the task of matching a mention to an entity in a given knowledge base (KB). It contributes to annotating a massive amount of documents existing on the Web to harness new facts about their matched entities. However,…

Computation and Language · Computer Science 2022-10-28 Hassan Soliman

The catalytic reaction system (CRS) formalism by Hordijk and Steel is a versatile method to model autocatalytic biochemical reaction networks. It is particularly suited, and has been widely used, to study self-sustainment and…

Molecular Networks · Quantitative Biology 2023-08-16 Dimitri Loutchko

Flow diagrams are a common tool used to help build and interpret models of dynamical systems, often in biological contexts such as consumer-resource models and similar compartmental models. Typically, their usage is intuitive and informal.…

Quantitative Methods · Quantitative Biology 2016-06-10 C. Brandon Ogbunugafor , Sean P. Robinson

We derive the nonequilibrium conductance matrix for open stationary Chemical Reaction Networks (CRNs) described by a deterministic mass action kinetic equation. As an illustration, we determine the nonequilibrium conductance matrix of a CRN…

Statistical Mechanics · Physics 2025-06-27 Paul Raux , Christophe Goupil , Gatien Verley

Computational techniques are required for narrowing down the vast space of possibilities to plausible prebiotic scenarios, since precise information on the molecular composition, the dominant reaction chemistry, and the conditions for that…

Molecular Networks · Quantitative Biology 2018-02-07 Jakob L. Andersen , Christoph Flamm , Daniel Merkle , Peter F. Stadler