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In this work, a systematic protocol is proposed to automatically parametrize implicit solvent models with polar and nonpolar components. The proposed protocol utilizes the classical Poisson model or the Kohn-Sham density functional theory…

Chemical Physics · Physics 2016-11-03 Bao Wang , Chengzhang Wang , Guowei Wei

The many-body $GW$ formalism, for the calculation of ionization potentials or electronic affinities, relies on the frequency-dependent dielectric function built from the electronic degrees of freedom. Considering the case of water as a…

Materials Science · Physics 2024-09-04 Ivan Duchemin , David Amblard , Xavier Blase

Theories of solvation free energies often involve electrostatic potentials at the position of a solute charge. Simulation calculations that apply cutoffs and periodic boundary conditions based on molecular centers result in center-dependent…

Chemical Physics · Physics 2008-02-03 Gerhard Hummer , Lawrence R. Pratt , Angel E. Garcia , Bruce J. Berne , Steven W. Rick

Ab initio modeling of electrochemical systems is becoming a key tool for understanding and predicting electrochemical behavior. Development and careful benchmarking of computational electrochemical methods are essential to ensure their…

Chemical Physics · Physics 2017-03-01 Ravishankar Sundararaman , Kathleen Schwarz

Employing a classical density-functional description of liquid environments, we introduce a rigorous method for the diffusion quantum Monte Carlo calculation of free energies and thermodynamic averages of solvated systems that requires…

We propose a generalisation of molecular density functional theory to describe inhomogeneous solvent mixture, with the objective of modelling electrolytic solutions. Two electrolytic models are presented, both within the HNC approximation.…

Chemical Physics · Physics 2025-11-13 Guillaume Jeanmairet , Luc Belloni , Daniel Borgis

Solvation free energy is an important quantity in Computational Chemistry with a variety of applications, especially in drug discovery and design. The accurate prediction of solvation free energies of small molecules in water is still a…

Biological Physics · Physics 2007-05-23 A. Hildebrandt , O. Kohlbacher , R. Blossey , H. -P. Lenhof

We implement a well-established concept to consider dispersion effects within a Poisson-Boltzmann approach of continuum solvation of proteins. The theoretical framework is particularly suited for boundary element methods. Free parameters…

Biological Physics · Physics 2007-11-28 Parimal Kar , Max Seel , Ulrich H. E. Hansmann , Siegfried Hoefinger

Delivering the full benefits of first principles calculations to battery materials demands the development of accurate and computationally-efficient electronic structure methods that incorporate the effects of the electrolyte environment…

Solid-liquid interfaces are at the heart of many modern-day technologies and provide a challenge to many materials simulation methods. A realistic first-principles computational study of such systems entails the inclusion of solvent…

Accurate calculations of solvation free energies remain a central challenge in molecular simulations, often requiring extensive sampling and numerous alchemical intermediates to ensure sufficient overlap between phase-space distributions of…

Statistical Mechanics · Physics 2026-04-02 Maximilian Schebek , Nikolas M. Froböse , Bettina G. Keller , Jutta Rogal

We demonstrate that with two small modifications, the popular dielectric continuum model is capable of predicting, with high accuracy, ion solvation thermodynamics in numerous polar solvents, and ion solvation free energies in…

A recently developed statistical mechanical Quasi-Chemical Theory (QCT) has led to significant insights into solvation phenomena for both hydrophilic and hydrophobic solutes. The QCT exactly partitions solvation free energies into three…

Statistical Mechanics · Physics 2009-11-13 David M. Rogers , Thomas L. Beck

A density functional theory for a macroion suspension is examined, where the excess free energy corresponds to the macroion self energy arising from the polarisation of the supporting electrolyte solution. This is treated within a…

Soft Condensed Matter · Physics 2007-05-23 Patrick B. Warren

Continuum solvent models have become a standard technique in the context of electronic structure calculations, yet, no implementations have been reported capable to perform molecular dynamics at solid-liquid interfaces. We propose here such…

Chemical Physics · Physics 2015-05-13 Veronica M. Sanchez , Mariela Sued , Damian A. Scherlis

Atomic radii and charges are two major parameters used in implicit solvent electrostatics and energy calculations. The optimization problem for charges and radii is under-determined, leading to uncertainty in the values of these parameters…

Biomolecules · Quantitative Biology 2017-12-25 Xiu Yang , Huan Lei , Peiyuan Gao , Dennis G. Thomas , David Mobley , Nathan A. Baker

Parametric correlations are studied in several classes of covariant density functional theories (CDFTs) using a statistical analysis in a large parameter hyperspace. In the present manuscript, we investigate such correlations for two…

Nuclear Theory · Physics 2020-03-17 A. Taninah , S. E. Agbemava , A. V. Afanasjev , P. Ring

We present the theory and implementation of a Poisson-Boltzmann implicit solvation model for electrolyte solutions. This model can be combined with arbitrary electronic structure methods that provide an accurate charge density of the…

Computational Physics · Physics 2020-01-08 Christopher J. Stein , John M. Herbert , Martin Head-Gordon

Density functional theory is used to describe electrolyte solutions in contact with electrodes of planar or spherical shape. For the electrolyte solutions we consider the so-called civilized model, in which all species present are treated…

Soft Condensed Matter · Physics 2017-04-24 Andreas Reindl , Markus Bier , S. Dietrich

This paper presents the development of a density-based solver suitable for cavitating flows in the OpenFOAM framework. In this solver, the thermodynamic equilibrium mixture approach is adopted to model the presence of and the phase…

Fluid Dynamics · Physics 2020-09-11 M. H. Arabnejad , R. E. Bensow