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A measure called Physical Complexity is established and calculated for a population of sequences, based on statistical physics, automata theory, and information theory. It is a measure of the quantity of information in an organism's genome.…

Biological Physics · Physics 2011-12-02 Gerard Briscoe , Philippe De Wilde

The major problem in information theoretic analysis of neural responses and other biological data is the reliable estimation of entropy--like quantities from small samples. We apply a recently introduced Bayesian entropy estimator to…

Data Analysis, Statistics and Probability · Physics 2009-09-29 Ilya Nemenman , William Bialek , Rob de Ruyter van Steveninck

We discuss the interest of escort distributions and R\'enyi entropy in the context of source coding. We first recall a source coding theorem by Campbell relating a generalized measure of length to the R\'enyi-Tsallis entropy. We show that…

Mathematical Physics · Physics 2011-09-16 J. -F. Bercher

Statistical regularities in human language have fascinated researchers for decades, suggesting deep underlying principles governing its evolution and information structuring for efficient communication. While Zipf's Law describes the…

Physics and Society · Physics 2025-04-29 Alessandro Bellina , Vito D. P. Servedio

We propose a formal expansion of the transfer entropy to put in evidence irreducible sets of variables which provide information for the future state of each assigned target. Multiplets characterized by a large contribution to the expansion…

Quantitative Methods · Quantitative Biology 2015-06-04 S. Stramaglia , Guo-Rong Wu , M. Pellicoro , D. Marinazzo

Biologists have long sought a way to explain how statistical properties of genetic sequences emerged and are maintained through evolution. On the one hand, non-random structures at different scales indicate a complex genome organisation. On…

Quantitative Methods · Quantitative Biology 2018-11-01 Giampaolo Cristadoro , Mirko Degli Esposti , Eduardo G. Altmann

During a spontaneous change, a macroscopic physical system will evolve towards a macro-state with more realizations. This observation is at the basis of the Statistical Mechanical version of the Second Law of Thermodynamics, and it provides…

Statistical Mechanics · Physics 2020-04-22 Mengjie Zu , Arunkumar Bupathy , Daan Frenkel , Srikanth Sastry

According to E.T. Jaynes and E.P. Wigner, entropy is an anthropomorphic concept in the sense that in a physical system correspond many thermodynamic systems. The physical system can be examined from many points of view each time examining…

Information Theory · Computer Science 2015-12-03 Panteleimon Rodis

Entropy is a measure of heterogeneity widely used in applied sciences, often when data are collected over space. Recently, a number of approaches has been proposed to include spatial information in entropy. The aim of entropy is to…

Statistics Theory · Mathematics 2019-11-12 Linda Altieri , Daniela Cocchi , Giulia Roli

We prime-encode the natural numbers via recursive factorisation, iterated to the exponents, generating a corpus of planar rooted trees equivalently represented as Dyck words. This forms a deterministic text endowed with internal rules.…

Mathematical Physics · Physics 2025-12-02 Pierluigi Contucci , Claudio Giberti , Godwin Osabutey , Cecilia Vernia

This paper investigates the information encoded in the embeddings of large language models (LLMs). We conduct simulations to analyze the representation entropy and discover a power law relationship with model sizes. Building upon this…

Machine Learning · Computer Science 2024-02-07 Zhiquan Tan , Chenghai Li , Weiran Huang

As a living information and communications system, the genome encodes patterns in single nucleotide polymorphisms (SNPs) reflecting human adaption that optimizes population survival in differing environments. This paper mathematically…

Populations and Evolution · Quantitative Biology 2018-03-22 James Lindesay , Tshela E. Mason , William Hercules , Georgia M. Dunston

The data we analyze derives from the observation of numerous cells of the bacterium Escherichia coli (E. coli) growing and dividing. Single cells grow and divide to give birth to two daughter cells, that in turn grow and divide. Thus, a…

Applications · Statistics 2015-09-18 Bernard Delyon , Benoîte de Saporta , Nathalie Krell , Lydia Robert

Repetitions within a given genealogical tree provides some information about the degree of consanguineity of a population. They can be analyzed with techniques usually employed in statistical physics when dealing with fixed point…

Statistical Mechanics · Physics 2009-10-31 Paolo De Los Rios , Oscar Pla

The mean length and the variability of coding sequences for 48 genomes of bacteria and archaea were analyzed. It was found that the plotted data can be described by an angular area. This suggests the followings: a) The variability of a…

Genomics · Quantitative Biology 2008-05-12 Vasile V. Morariu

Compression of integer sets and sequences has been extensively studied for settings where elements follow a uniform probability distribution. In addition, methods exist that exploit clustering of elements in order to achieve higher…

Information Theory · Computer Science 2014-02-11 N. Jesper Larsson

We present a theoretical as well as experimental investigation of a population of self-replicating segments of code subject to random mutation and survival of the fittest. Under the assumption that such a system constitutes a minimal system…

adap-org · Physics 2008-02-03 Chris Adami

Inferring the directionality of interactions between cellular processes is a major challenge in systems biology. Time-lagged correlations allow to discriminate between alternative models, but they still rely on assumed underlying…

Quantitative Methods · Quantitative Biology 2017-11-15 Sourabh Lahiri , Philippe Nghe , Sander J. Tans , Martin Luc Rosinberg , David Lacoste

Dynamical properties of the transcriptional regulatory network of {\it Escherichia coli} and {\it Saccharomyces cerevisiae} are studied within the framework of random Boolean functions. The dynamical response of these networks to a single…

Molecular Networks · Quantitative Biology 2007-05-23 Deok-Sun Lee , Heiko Rieger

We investigate the origin of Zipf's law for words in written texts by means of a stochastic dynamical model for text generation. The model incorporates both features related to the general structure of languages and memory effects inherent…

Statistical Mechanics · Physics 2007-05-23 Damián H. Zanette , Marcelo A. Montemurro
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