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Complex systems with tightly coadapted parts frequently appear in living systems and are difficult to account for through Darwinian evolution, that is random variation and natural selection, if the constituent parts are independently coded…

Adaptation and Self-Organizing Systems · Physics 2007-05-23 John F. McGowan , Ph. D

A topic of great current interest is Causal Representation Learning (CRL), whose goal is to learn a causal model for hidden features in a data-driven manner. Unfortunately, CRL is severely ill-posed since it is a combination of the two…

Machine Learning · Statistics 2024-06-10 Hiroshi Morioka , Aapo Hyvärinen

Graphs are a powerful data structure for representing relational data and are widely used to describe complex real-world systems. Probabilistic Graphical Models (PGMs) and Graph Neural Networks (GNNs) can both leverage graph-structured…

Machine Learning · Statistics 2025-08-26 Michela Lapenna , Caterina De Bacco

Multiplexed immunofluorescence provides an unprecedented opportunity for studying specific cell-to-cell and cell microenvironment interactions. We employ graph neural networks to combine features obtained from tissue morphology with…

Self-organized emergent patterns can be widely seen in particle interactions producing complex structures such as chemical elements and molecules. Inspired by these interactions, this work presents a novel stochastic approach that allows a…

Robotics · Computer Science 2022-09-01 Paulo Rezeck , Luiz Chaimowicz

The Random Geometric Graph (RGG) is a random graph model for network data with an underlying spatial representation. Geometry endows RGGs with a rich dependence structure and often leads to desirable properties of real-world networks such…

Social and Information Networks · Computer Science 2022-08-25 Quentin Duchemin , Yohann de Castro

Tree-based algorithms such as random forests and gradient boosted trees continue to be among the most popular and powerful machine learning models used across multiple disciplines. The conventional wisdom of estimating the impact of a…

Machine Learning · Statistics 2022-01-03 Markus Loecher , Qi Wu

The quality of generalized linear models (GLMs), frequently used by insurance companies, depends on the choice of interacting variables. The search for interactions is time-consuming, especially for data sets with a large number of…

Machine Learning · Statistics 2025-05-21 Yevhen Havrylenko , Julia Heger

Recent improvements in conditional generative modeling have made it possible to generate high-quality images from language descriptions alone. We investigate whether these methods can directly address the problem of sequential…

Machine Learning · Computer Science 2023-07-11 Anurag Ajay , Yilun Du , Abhi Gupta , Joshua Tenenbaum , Tommi Jaakkola , Pulkit Agrawal

High-dimensional networks play a key role in understanding complex relationships. These relationships are often dynamic in nature and can change with multiple external factors (e.g., time and groups). Methods for estimating graphical models…

Methodology · Statistics 2024-07-30 Louis Dijkstra , Arne Godt , Ronja Foraita

Correlation among the observations in high-dimensional regression modeling can be a major source of confounding. We present a new open-source package, plmmr, to implement penalized linear mixed models in R. This R package estimates…

Computation · Statistics 2026-05-13 Tabitha K. Peter , Anna C. Reisetter , Yujing Lu , Oscar A. Rysavy , Patrick J. Breheny

Virtual cell modeling aims to predict cellular responses to perturbations. Existing virtual cell models rely heavily on large-scale single-cell datasets, learning explicit mappings between gene expression and perturbations. Although recent…

Cell Behavior · Quantitative Biology 2026-03-02 Zhijian Wei , Runze Ma , Zichen Wang , Zhongmin Li , Shuotong Song , Shuangjia Zheng

Gibbs random fields (GRF) are polymorphous statistical models that can be used to analyse different types of dependence, in particular for spatially correlated data. However, when those models are faced with the challenge of selecting a…

Conditional probabilistic graphical models provide a powerful framework for structured regression in spatio-temporal datasets with complex correlation patterns. However, in real-life applications a large fraction of observations is often…

Machine Learning · Computer Science 2018-03-29 Jelena Stojanovic , Milos Jovanovic , Djordje Gligorijevic , Zoran Obradovic

Plasticity-led evolution is a form of evolution where a change in the environment induces novel traits via phenotypic plasticity, after which the novel traits are genetically accommodated over generations under the novel environment. This…

Populations and Evolution · Quantitative Biology 2023-01-18 Eden Tian Hwa Ng , Akira R. Kinjo

In this paper I review the submission to the Explaining the Human Visual Brain Challenge 2019 in both the fMRI and MEG tracks. The goal was to construct neural network features which generate the so-called representational dissimilarity…

Neurons and Cognition · Quantitative Biology 2019-07-02 Romuald A. Janik

Achieving photorealistic rendering of real-world scenes poses a significant challenge with diverse applications, including mixed reality and virtual reality. Neural networks, extensively explored in solving differential equations, have…

Computer Vision and Pattern Recognition · Computer Science 2023-11-09 YuanFu Yang , Min Sun

The need to measure sequence similarity arises in information extraction, object identity, data mining, biological sequence analysis, and other domains. This paper presents discriminative string-edit CRFs, a finitestate conditional random…

Machine Learning · Computer Science 2012-07-09 Andrew McCallum , Kedar Bellare , Fernando Pereira

In the analysis of complex traits, genetic effects are frequently modelled as either fixed or random effects. Such assumptions serve as a foundation of defining heritability and relatedness using genome-wide single nucleotide polymorphism…

Populations and Evolution · Quantitative Biology 2023-04-28 Hanbin Lee

Temporal collaborative filtering (TCF) methods aim at modelling non-static aspects behind recommender systems, such as the dynamics in users' preferences and social trends around items. State-of-the-art TCF methods employ recurrent neural…

Artificial Intelligence · Computer Science 2020-10-14 Esther Rodrigo Bonet , Duc Minh Nguyen , Nikos Deligiannis
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