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Automatically extracting Protein-Protein Interactions (PPI) from biomedical literature provides additional support for precision medicine efforts. This paper proposes a novel memory network-based model (MNM) for PPI extraction, which…

Computation and Language · Computer Science 2020-01-08 Huiwei Zhou , Zhuang Liu , Shixian Ning , Yunlong Yang , Chengkun Lang , Yingyu Lin , Kun Ma

Label-free cell classification is advantageous for supplying pristine cells for further use or examination, yet existing techniques frequently fall short in terms of specificity and speed. In this study, we address these limitations through…

Image and Video Processing · Electrical Eng. & Systems 2025-02-25 Khayrul Islam , Ratul Paul , Shen Wang , Yuwen Zhao , Partho Adhikary , Qiying Li , Xiaochen Qin , Yaling Liu

The Class Activation Map (CAM) lookup of a neural network tells us to which regions the neural network focuses when it makes a decision. In the past, the CAM search method was dependent upon a specific internal module of the network. It has…

Computer Vision and Pattern Recognition · Computer Science 2022-08-16 Yitao Peng , Longzhen Yang , Yihang Liu , Lianghua He

Background:Typically, proteins perform key biological functions by interacting with each other. As a consequence, predicting which protein pairs interact is a fundamental problem. Experimental methods are slow, expensive, and may be error…

Biomolecules · Quantitative Biology 2022-02-08 Leonardo Martini , Adriano Fazzone , Luca Becchetti

Even though machine learning algorithms already play a significant role in data science, many current methods pose unrealistic assumptions on input data. The application of such methods is difficult due to incompatible data formats, or…

Machine Learning · Computer Science 2022-06-09 Simon Mandlik , Tomas Pevny

SimMIM is a widely used method for pretraining vision transformers using masked image modeling. However, despite its success in fine-tuning performance, it has been shown to perform sub-optimally when used for linear probing. We propose an…

Computer Vision and Pattern Recognition · Computer Science 2025-01-03 Madhava Krishna , A V Subramanyam

From the simple measurement of tissue attributes in pathology workflow to designing an explainable diagnostic/prognostic AI tool, access to accurate semantic segmentation of tissue regions in histology images is a prerequisite. However,…

Image and Video Processing · Electrical Eng. & Systems 2021-08-31 Mostafa Jahanifar , Neda Zamani Tajeddin , Navid Alemi Koohbanani , Nasir Rajpoot

We propose a novel framework, called Disjoint Mapping Network (DIMNet), for cross-modal biometric matching, in particular of voices and faces. Different from the existing methods, DIMNet does not explicitly learn the joint relationship…

Computer Vision and Pattern Recognition · Computer Science 2018-07-17 Yandong Wen , Mahmoud Al Ismail , Weiyang Liu , Bhiksha Raj , Rita Singh

The software for chemical interaction networks (SCINE) project aims at pushing the frontier of quantum chemical calculations on molecular structures to a new level. While calculations on individual structures as well as on simple relations…

In the big data era, the relationship between entries becomes more and more complex. Many graph (or network) algorithms have already paid attention to dynamic networks, which are more suitable than static ones for fitting the complex…

Machine Learning · Computer Science 2022-11-17 Dongqi Fu , Jingrui He

Storyline drawings are a popular visualization of interactions of a set of characters over time, e.g., to show participants of scenes in a book or movie. Characters are represented as $x$-monotone curves that converge vertically for…

Data Structures and Algorithms · Computer Science 2024-09-05 Alexander Dobler , Michael Jünger , Paul J. Jünger , Julian Meffert , Petra Mutzel , Martin Nöllenburg

In this paper we address the problem of protein classification starting from a multi-view 2D representation of proteins. From each 3D protein structure, a large set of 2D projections is generated using the protein visualization software…

Computer Vision and Pattern Recognition · Computer Science 2019-10-30 Loris Nanni , Alessandra Lumini , Federica Pasquali , Sheryl Brahnam

Proteins play a vital role in biological processes and are indispensable for living organisms. Accurate representation of proteins is crucial, especially in drug development. Recently, there has been a notable increase in interest in…

Biomolecules · Quantitative Biology 2026-05-28 Dan Kalifa , Uriel Singer , Kira Radinsky

A novel framework has recently been proposed for designing the molecular structure of chemical compounds with a desired chemical property using both artificial neural networks and mixed integer linear programming. In the framework, a…

Machine Learning · Computer Science 2021-08-24 Naveed Ahmed Azam , Jianshen Zhu , Kazuya Haraguchi , Liang Zhao , Hiroshi Nagamochi , Tatsuya Akutsu

Protein-protein interactions (PPIs) are crucial in various biological processes and their study has significant implications for drug development and disease diagnosis. Existing deep learning methods suffer from significant performance…

Molecular Networks · Quantitative Biology 2023-05-16 Ziyuan Zhao , Peisheng Qian , Xulei Yang , Zeng Zeng , Cuntai Guan , Wai Leong Tam , Xiaoli Li

Over the past decade, deep learning (DL) research in computer vision has been growing rapidly, with many advances in DL-based image analysis methods for biomedical problems. In this work, we introduce MMV_Im2Im, a new open-source python…

Image and Video Processing · Electrical Eng. & Systems 2023-03-20 Justin Sonneck , Jianxu Chen

It has recently been demonstrated that many biological networks exhibit a scale-free topology where the probability of observing a node with a certain number of edges (k) follows a power law: i.e. p(k) ~ k^-g. This observation has been…

Molecular Networks · Quantitative Biology 2009-11-11 Eric J. Deeds , Orr Ashenberg , Eugene I. Shakhnovich

Computational methods for predicting the interface contacts between proteins come highly sought after for drug discovery as they can significantly advance the accuracy of alternative approaches, such as protein-protein docking, protein…

Machine Learning · Computer Science 2022-03-08 Alex Morehead , Chen Chen , Jianlin Cheng

Several visualization schemes have been developed for imaging materials at the atomic level through atom probe tomography. The main shortcoming of these tools is their inability to parallel process data using multi-core computing units to…

Materials Science · Physics 2012-02-07 Hari Dahal , Michael Stukowski , Matthias J. Graf , Alexander V. Balatsky , Krishna Rajan

Protein representation learning is critical in various tasks in biology, such as drug design and protein structure or function prediction, which has primarily benefited from protein language models and graph neural networks. These models…

Biomolecules · Quantitative Biology 2024-02-16 Bozhen Hu , Zelin Zang , Cheng Tan , Stan Z. Li