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Multiple sampling strategies commonly used in molecular dynamics, such as umbrella sampling and alchemical free energy methods, involve sampling from multiple thermodynamic states. Commonly, the data are then recombined to construct…

Statistical Mechanics · Physics 2023-06-14 Xiang Sherry Li , Brian Van Koten , Aaron R. Dinner , Erik H. Thiede

Time series of matrix-valued data are increasingly available in various areas including economics, finance, social science, among others. These data may shed light on the inter-dynamical relationships between two sets of attributes, for…

Methodology · Statistics 2026-04-22 Fei Wu , Kung-Sik Chan

The estimation of rare event probabilities plays a pivotal role in diverse fields. Our aim is to determine the probability of a hazard or system failure occurring when a quantity of interest exceeds a critical value. In our approach, the…

Methodology · Statistics 2025-04-11 Lea Friedli , David Ginsbourger , Arnaud Doucet , Niklas Linde

With electric power systems becoming more compact and increasingly powerful, the relevance of thermal stress especially during overload operation is expected to increase ceaselessly. Whenever critical temperatures cannot be measured…

Machine Learning · Computer Science 2022-11-03 Wilhelm Kirchgässner , Oliver Wallscheid , Joachim Böcker

Machine learning tools are commonly used in modern high energy physics (HEP) experiments. Different models, such as boosted decision trees (BDT) and artificial neural networks (ANN), are widely used in analyses and even in the software…

Data Analysis, Statistics and Probability · Physics 2016-12-21 A. Rogozhnikov

Many state of the art methods for the thermodynamic and kinetic characterization of large and complex biomolecular systems by simulation rely on ensemble approaches, where data from large numbers of relatively short trajectories are…

Data Analysis, Statistics and Probability · Physics 2017-04-05 Feliks Nüske , Hao Wu , Jan-Hendrik Prinz , Christoph Wehmeyer , Cecilia Clementi , Frank Noé

We provide an algorithm based on weighted-ensemble (WE) methods, to accurately sample systems at steady state. Applying our method to different one- and two-dimensional models, we succeed to calculate steady state probabilities of order…

Statistical Mechanics · Physics 2015-06-15 Justus A. Kromer , Lutz Schimansky-Geier , Raul Toral

We present an algorithm for finding the probabilities of rare events in nonequilibrium processes. The algorithm consists of evolving the system with a modified dynamics for which the required event occurs more frequently. By keeping track…

Statistical Mechanics · Physics 2011-04-07 Anupam Kundu , Sanjib Sabhapandit , Abhishek Dhar

We analyze experimental data obtained from an electrical circuit having components at different temperatures, showing how to predict its response to temperature variations. This illustrates in detail how to utilize a recent linear response…

Statistical Mechanics · Physics 2016-09-07 Marco Baiesi , Sergio Ciliberto , Gianmaria Falasco , Cem Yolcu

In this paper, three ensemble methods: Random Forest, XGBoost, and a Hybrid Ensemble method were implemented to classify imbalanced pulsar candidates. To assist these methods, tree models were used to select features among 30 features of…

Instrumentation and Methods for Astrophysics · Physics 2019-09-24 Yuanchao Wang , Zhichen Pan , Jianhua Zheng , Lei Qian , Mingtao Li

The minimum action method (MAM) is to calculate the most probable transition path in randomly perturbed stochastic dynamics, based on the idea of action minimization in the path space. The accuracy of the numerical path between different…

Computational Physics · Physics 2017-05-26 Y Sun , X Zhou

Based on multiple simulation trajectories, which started from dispersively selected initial conformations, the weighted ensemble dynamics method is designed to robustly and systematically explore the hierarchical structure of complex…

Statistical Mechanics · Physics 2015-05-14 Linchen Gong , Xin Zhou

We investigate the theoretical foundations of the simulated tempering method and use our findings to design efficient algorithms. Employing a large deviation argument first used for replica exchange molecular dynamics [Plattner et al., J.…

Chemical Physics · Physics 2019-02-08 Anton Martinsson , Jianfeng Lu , Benedict Leimkuhler , Eric Vanden-Eijnden

This article proposes a transfer reinforcement learning (RL) based adaptive energy managing approach for a hybrid electric vehicle (HEV) with parallel topology. This approach is bi-level. The up-level characterizes how to transform the…

Systems and Control · Electrical Eng. & Systems 2020-07-27 Teng Liu , Wenhao Tan , Xiaolin Tang , Jiaxin Chen , Dongpu Cao

During reactive transport modeling, the computational cost associated with chemical reaction calculations is often 10-100 times higher than that of transport calculations. Most of these costs results from chemical equilibrium calculations…

Optimization and Control · Mathematics 2017-08-17 Allan M. M. Leal , Dmitrii A. Kulik , Martin O. Saar

An important challenge in statistical analysis concerns the control of the finite sample bias of estimators. For example, the maximum likelihood estimator has a bias that can result in a significant inferential loss. This problem is…

Statistics Theory · Mathematics 2019-11-04 Stéphane Guerrier , Mucyo Karemera , Samuel Orso , Maria-Pia Victoria-Feser

We present a new and efficient method for computing the transition pathways, free energy barriers, and transition rates in complex systems with relatively smooth energy landscapes. The method proceeds by evolving strings, i.e. smooth curves…

Condensed Matter · Physics 2009-11-07 Weinan E , Weiqing Ren , Eric Vanden-Eijnden

Markov state models (MSMs) have been broadly adopted for analyzing molecular dynamics trajectories, but the approximate nature of the models that results from coarse-graining into discrete states is a long-known limitation. We show…

Computational Physics · Physics 2021-05-31 John D. Russo , Jeremy Copperman , David Aristoff , Gideon Simpson , Daniel M. Zuckerman

For the simulation of equilibrium states and finite-temperature response functions of strongly-correlated quantum many-body systems, we compare the efficiencies of two different approaches in the framework of the density matrix…

Strongly Correlated Electrons · Physics 2017-01-03 Moritz Binder , Thomas Barthel

In probabilistic quantum metrology, one aims at finding weak measurements that concentrate the Fisher Information on the resulting quantum states, post-selected according to the weak outcomes. Though the Quantum Cram\'er-Rao bound itself…

Quantum Physics · Physics 2022-07-08 Massimo Frigerio , Stefano Olivares , Matteo G. A. Paris