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Neocortical neurons have thousands of excitatory synapses. It is a mystery how neurons integrate the input from so many synapses and what kind of large-scale network behavior this enables. It has been previously proposed that non-linear…

Neurons and Cognition · Quantitative Biology 2016-04-25 Jeff Hawkins , Subutai Ahmad

Living neural networks in our brains autonomously self-organize into large, complex architectures during early development to result in an organized and functional organic computational device. A key mechanism that enables the formation of…

Neural and Evolutionary Computing · Computer Science 2020-06-15 Guruprasad Raghavan , Cong Lin , Matt Thomson

Electrical signaling in the brain plays a vital role to our existence but at the same time, the fundamental mechanism of this propagation is undeciphered. Notable advancements have been made in the numerical modeling supplementing the…

Neurons and Cognition · Quantitative Biology 2024-11-11 Rahul Gulati , Shiva Rudraraju

While the human brain efficiently adapts to new tasks from a continuous stream of information, neural network models struggle to learn from sequential information without catastrophically forgetting previously learned tasks. This limitation…

Neural and Evolutionary Computing · Computer Science 2024-06-12 Lorenzo Pes , Rick Luiken , Federico Corradi , Charlotte Frenkel

Signal propagation in neuronal dendrites represents the basis for interneuron communication and information processing in the brain. Here we take into account charge inhomogeneities arising in the vicinity of ion channels in cytoplasm and…

Neurons and Cognition · Quantitative Biology 2013-12-25 Ivan A. Lazarevich , Victor B. Kazantsev

Sensory perception (e.g. vision) relies on a hierarchy of cortical areas, in which neural activity propagates in both directions, to convey information not only about sensory inputs but also about cognitive states, expectations and…

Neurons and Cognition · Quantitative Biology 2023-04-13 Grégory Faye , Guilhem Fouilhé , Rufin VanRullen

We propose a mathematical framework to systematically explore the propagation properties of a class of continuous in time nonlinear neural network models comprising a hierarchy of processing areas, mutually connected according to the…

Analysis of PDEs · Mathematics 2025-05-15 Andrea Alamia , Léa Dalliès , Grégory Faye , Rufin Vanrullen

Starting from the morphological-functional assumption of the fractal brain, a mathematical model is given by activating brain non-differentiable dynamics through the determinism-nondeterminism inference of the responsible mechanisms. The…

Neurons and Cognition · Quantitative Biology 2015-11-18 Maricel Agop , Alina Gavrilut , Gabriel Crumpei , Mitica Craus , Vlad Birlescu

Conceptual and mathematical models of neurons have lagged behind empirical understanding for decades. Here we extend previous work in modeling biological systems with fully scale-independent quantum information-theoretic tools to develop a…

Neurons and Cognition · Quantitative Biology 2022-07-21 Chris Fields , James F. Glazebrook , Michael Levin

We study a model of spiking neurons, with recurrent connections that result from learning a set of spatio-temporal patterns with a spike-timing dependent plasticity rule and a global inhibition. We investigate the ability of the network to…

Neurons and Cognition · Quantitative Biology 2020-04-22 S. Scarpetta , A. de Candia

This paper proposes a neuronal circuitry layout and synaptic plasticity principles that allow the (pyramidal) neuron to act as a "combinatorial switch". Namely, the neuron learns to be more prone to generate spikes given those combinations…

Biological Physics · Physics 2017-05-09 Marat M. Rvachev

The bottom two layers of a neuromorphic architecture are designed and shown to be capable of online clustering and supervised classification. An active spiking dendrite model is used, and a single dendritic segment performs essentially the…

Neural and Evolutionary Computing · Computer Science 2023-10-30 J. E. Smith

Mounting experimental evidence suggests that brain-state-specific neural mechanisms, supported by connectomic architectures, play a crucial role in integrating past and contextual knowledge with the current, incoming flow of evidence (e.g.,…

Encoding models are used for predicting brain activity in response to sensory stimuli with the objective of elucidating how sensory information is represented in the brain. Encoding models typically comprise a nonlinear transformation of…

Neurons and Cognition · Quantitative Biology 2017-03-13 Umut Güçlü , Marcel A. J. van Gerven

The brain is immensely complex, with diverse components and dynamic interactions building upon one another to orchestrate a wide range of functions and behaviors. Understanding patterns of these complex interactions and how they are…

Neurons and Cognition · Quantitative Biology 2024-08-06 Suman Kulkarni , Dani S. Bassett

Traveling waves of neural activity have been observed throughout the brain at a diversity of regions and scales; however, their precise computational role is still debated. One physically inspired hypothesis suggests that the cortical sheet…

Neural and Evolutionary Computing · Computer Science 2024-03-18 T. Anderson Keller , Lyle Muller , Terrence Sejnowski , Max Welling

Efficient path planning and navigation is critical for animals, robotics, logistics and transportation. We study a model in which spatial navigation problems can rapidly be solved in the brain by parallel mental exploration of alternative…

Neurons and Cognition · Quantitative Biology 2012-05-03 Filip Ponulak , John J. Hopfield

Large-scale white matter pathways crisscrossing the cortex create a complex pattern of connectivity that underlies human cognitive function. Generative mechanisms for this architecture have been difficult to identify in part because little…

Neurons and Cognition · Quantitative Biology 2015-06-16 Florian Klimm , Danielle S. Bassett , Jean M. Carlson , Peter J. Mucha

Local patterns of excitation and inhibition that can generate neural waves are studied as a computational mechanism underlying the organization of neuronal tunings. Sparse coding algorithms based on networks of excitatory and inhibitory…

Neurons and Cognition · Quantitative Biology 2022-05-30 Leon Lufkin , Ashish Puri , Ganlin Song , Xinyi Zhong , John Lafferty

In the intricate architecture of the mammalian central nervous system, neurons form populations. Axonal bundles communicate between these clusters using spike trains. However, these neuron populations' precise encoding and operations have…

Neurons and Cognition · Quantitative Biology 2024-01-02 Martin N. P. Nilsson