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We consider statistical inference in high-dimensional regression problems under affine constraints on the parameter space. The theoretical study of this is motivated by the study of genetic determinants of diseases, such as diabetes, using…

While branching network structures abound in nature, their objective analysis is more difficult than expected because existing quantitative methods often rely on the subjective judgment of branch structures. This problem is particularly…

Algebraic Topology · Mathematics 2024-02-13 Haruhisa Oda , Mayuko Kida , Yoichi Nakata , Hiroki Kurihara

In this paper, we develop a graphical modeling framework for the inference of networks across multiple sample groups and data types. In medical studies, this setting arises whenever a set of subjects, which may be heterogeneous due to…

In this paper we develop a novel Topological Data Analysis (TDA) approach for studying graph representations of time series of dynamical systems. Specifically, we show how persistent homology, a tool from TDA, can be used to yield a…

Chaotic Dynamics · Physics 2020-01-28 Audun Myers , Elizabeth Munch , Firas A. Khasawneh

Persistent homology is a popular computational tool for analyzing the topology of point clouds, such as the presence of loops or voids. However, many real-world datasets with low intrinsic dimensionality reside in an ambient space of much…

Machine Learning · Computer Science 2024-11-01 Sebastian Damrich , Philipp Berens , Dmitry Kobak

We develop a language for describing the relationship among observations, mathematical models, and the underlying principles from which they are derived. Using Information Geometry, we consider geometric properties of statistical models for…

Data Analysis, Statistics and Probability · Physics 2016-07-14 Mark K. Transtrum , Gus Hart , Peng Qiu

Topology identification and inference of processes evolving over graphs arise in timely applications involving brain, transportation, financial, power, as well as social and information networks. This chapter provides an overview of graph…

Signal Processing · Electrical Eng. & Systems 2025-12-12 Gonzalo Mateos , Yanning Shen , Georgios B. Giannakis , Ananthram Swami

Persistent homology is used to track the appearance and disappearance of features as we move through a nested sequence of topological spaces. Equating the nested sequence to a filtration and the appearance and disappearance of features to…

Statistics Theory · Mathematics 2020-12-17 Kathryn Garside , Aida Gjoka , Robin Henderson , Hollie Johnson , Irina Makarenko

The topology of the large-scale structure of the universe contains valuable information on the underlying cosmological parameters. While persistent homology can extract this topological information, the optimal method for parameter…

Cosmology and Nongalactic Astrophysics · Physics 2025-07-08 Jacky H. T. Yip , Adam Rouhiainen , Gary Shiu

Pathogen genome data offers valuable structure for spatial models, but its utility is limited by incomplete sequencing coverage. We propose a probabilistic framework for inferring genetic distances between unsequenced cases and known…

Genomics · Quantitative Biology 2025-09-10 Haley Stone , Jing Du , Hao Xue , Matthew Scotch , David Heslop , Andreas Züfle , Chandini Raina MacIntyre , Flora Salim

Topological Data Analysis (TDA) offers a suite of computational tools that provide quantified shape features in high dimensional data that can be used by modern statistical and predictive machine learning (ML) models. In particular,…

Cryptography and Security · Computer Science 2023-07-06 Dominic Gold , Koray Karabina , Francis C. Motta

Although there is no doubt that multi-parameter persistent homology is a useful tool to analyse multi-variate data, efficient ways to compute these modules are still lacking in the available topological data analysis toolboxes. Other issues…

Algebraic Topology · Mathematics 2021-04-15 Asilata Bapat , Robyn Brooks , Celia Hacker , Claudia Landi , Barbara I. Mahler

Many datasets can be viewed as a noisy sampling of an underlying space, and tools from topological data analysis can characterize this structure for the purpose of knowledge discovery. One such tool is persistent homology, which provides a…

A standard problem in applied topology is how to discover topological invariants of data from a noisy point cloud that approximates it. We consider the case where a sample is drawn from a properly embedded C1-submanifold without boundary in…

General Topology · Mathematics 2026-03-03 Sara Kalisnik , Davorin Lesnik

One of the primary areas of interest in applied algebraic topology is persistent homology, and, more specifically, the persistence diagram. Persistence diagrams have also become objects of interest in topological data analysis. However,…

Methodology · Statistics 2018-04-06 Eric Berry , Yen-Chi Chen , Jessi Cisewski-Kehe , Brittany Terese Fasy

We study detection of collapse in high-dimensional point clouds, where mass concentrates near a lower-dimensional set relative to a non-collapsed geometry. We propose persistent homology-based test statistics under two well-studied…

Computational Geometry · Computer Science 2026-04-30 Alexander Kalinowski

Recently a new feature representation and data analysis methodology based on a topological tool called persistent homology (and its corresponding persistence diagram summary) has started to attract momentum. A series of methods have been…

Computational Geometry · Computer Science 2019-12-13 Qi Zhao , Yusu Wang

Topological methods can provide a way of proposing new metrics and methods of scrutinising data, that otherwise may be overlooked. In this work, a method of quantifying the shape of data, via a topic called topological data analysis will be…

Machine Learning · Statistics 2022-09-25 Tristan Gowdridge , Nikolaos Dervilis , Keith Worden

Persistent homology theory is a relatively new but powerful method in data analysis. Using simplicial complexes, classical persistent homology is able to reveal high dimensional geometric structures of datasets, and represent them as…

Algebraic Topology · Mathematics 2023-12-05 Yaru Gao , Yan Xu , Fengchun Lei

Persistent homology (PH) is a method used in topological data analysis (TDA) to study qualitative features of data that persist across multiple scales. It is robust to perturbations of input data, independent of dimensions and coordinates,…

Algebraic Topology · Mathematics 2017-09-13 Nina Otter , Mason A. Porter , Ulrike Tillmann , Peter Grindrod , Heather A. Harrington