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Sequencing by Emergence (SEQE) is a new single-molecule nucleic acid (DNA/RNA) sequencing technology that estimates sequence as an emergent property of the binding and localization of a repertoire of short oligonucleotide probes. SEQE…

Genomics · Quantitative Biology 2021-08-04 Nicholas Boyd , Samuel Woodhouse , Kalim Mir

Diffusion Transformers (DiT) are powerful generative models but remain computationally intensive due to their iterative structure and deep transformer stacks. To alleviate this inefficiency, we propose \textbf{FastCache}, a…

Machine Learning · Computer Science 2026-03-30 Dong Liu , Yanxuan Yu , Jiayi Zhang , Yifan Li , Ben Lengerich , Ying Nian Wu

Contemporary deep learning, characterized by the training of cumbersome neural networks on massive datasets, confronts substantial computational hurdles. To alleviate heavy data storage burdens on limited hardware resources, numerous…

Computer Vision and Pattern Recognition · Computer Science 2024-12-24 Muquan Li , Dongyang Zhang , Qiang Dong , Xiurui Xie , Ke Qin

Quantization has been an effective technology in ANN (approximate nearest neighbour) search due to its high accuracy and fast search speed. To meet the requirement of different applications, there is always a trade-off between retrieval…

Computer Vision and Pattern Recognition · Computer Science 2020-12-08 Jingkuan Song , Xiaosu Zhu , Lianli Gao , Xin-Shun Xu , Wu Liu , Heng Tao Shen

High-dimensional Nearest Neighbor (NN) search is central in multimedia search systems. Product Quantization (PQ) is a widespread NN search technique which has a high performance and good scalability. PQ compresses high-dimensional vectors…

Computer Vision and Pattern Recognition · Computer Science 2019-05-17 Fabien André , Anne-Marie Kermarrec , Nicolas Le Scouarnec

Advances in DNA sequencing technology will soon result in databases of thousands of genomes. Within a species, individuals' genomes are almost exact copies of each other; e.g., any two human genomes are 99.9% the same. Relative Lempel-Ziv…

Data Structures and Algorithms · Computer Science 2011-11-08 Travis Gagie , Juha Kärkkäinen , Yakov Nekrich , Simon J. Puglisi

In this paper, we propose a product quantization table (PQTable); a fast search method for product-quantized codes via hash-tables. An identifier of each database vector is associated with the slot of a hash table by using its PQ-code as a…

Computer Vision and Pattern Recognition · Computer Science 2017-04-24 Yusuke Matsui , Toshihiko Yamasaki , Kiyoharu Aizawa

Due to its longevity and enormous information density, DNA is an attractive medium for archival data storage. Thanks to rapid technological advances, DNA storage is becoming practically feasible, as demonstrated by a number of experimental…

Information Theory · Computer Science 2022-11-11 Ilan Shomorony , Reinhard Heckel

Rapid analysis of DNA sequences is important in preventing the evolution of different viruses and bacteria during an early phase, early diagnosis of genetic predispositions to certain diseases (cancer, cardiovascular diseases), and in DNA…

Distributed, Parallel, and Cluster Computing · Computer Science 2015-09-07 Suejb Memeti , Sabri Pllana

Reading comprehension models are based on recurrent neural networks that sequentially process the document tokens. As interest turns to answering more complex questions over longer documents, sequential reading of large portions of text…

Computation and Language · Computer Science 2018-09-11 Mor Geva , Jonathan Berant

Approximate $k$-nearest neighbor (AKNN) search is a fundamental problem with wide applications. To reduce memory and accelerate search, vector quantization is widely adopted. However, existing quantization methods either rely on codebooks…

Databases · Computer Science 2026-02-04 Mingyu Yang , Liuchang Jing , Wentao Li , Wei Wang

There is a plethora of datasets in various formats which are usually stored in files, hosted in catalogs, or accessed through SPARQL endpoints. In most cases, these datasets cannot be straightforwardly explored by end users, for satisfying…

Databases · Computer Science 2018-12-31 Anna Kokolaki , Yannis Tzitzikas

DNA methylation is a well-studied genetic modification crucial to regulate the functioning of the genome. Its alterations play an important role in tumorigenesis and tumor-suppression. Thus, studying DNA methylation data may help biomarker…

Genomics · Quantitative Biology 2018-04-16 Fabrizio Celli , Fabio Cumbo , Emanuel Weitschek

Decompressing a file made by the gzip program at an arbitrary location is in principle impossible, due to the nature of the DEFLATE compression algorithm. Consequently, no existing program can take advantage of parallelism to rapidly…

Data Structures and Algorithms · Computer Science 2019-05-20 Maël Kerbiriou , Rayan Chikhi

Relative compression, where a set of similar strings are compressed with respect to a reference string, is a very effective method of compressing DNA datasets containing multiple similar sequences. Relative compression is fast to perform…

Quantitative Methods · Quantitative Biology 2011-06-21 Shanika Kuruppu , Simon Puglisi , Justin Zobel

Many datasets exhibit a well-defined structure that can be exploited to design faster search tools, but it is not always clear when such acceleration is possible. Here, we introduce a framework for similarity search based on characterizing…

Data Structures and Algorithms · Computer Science 2015-09-22 Y. William Yu , Noah M. Daniels , David Christian Danko , Bonnie Berger

Data compression plays an important role to deal with high volumes of DNA sequences in the field of Bioinformatics. Again data compression techniques directly affect the alignment of DNA sequences. So the time needed to decompress a…

Computational Engineering, Finance, and Science · Computer Science 2012-11-13 Subhankar Roy , Sunirmal Khatua , Sudipta Roy , Samir K. Bandyopadhyay

Retrieving the most similar vector embeddings to a given query among a massive collection of vectors has long been a key component of countless real-world applications. The recently introduced Retrieval-Augmented Generation is one of the…

Machine Learning · Computer Science 2024-02-06 Cecilia Aguerrebere , Mark Hildebrand , Ishwar Singh Bhati , Theodore Willke , Mariano Tepper

The exponential growth of DNA sequencing data has outpaced traditional heuristic-based methods, which struggle to scale effectively. Efficient computational approaches are urgently needed to support large-scale similarity search, a…

Modern biological science produces vast amounts of genomic sequence data. This is fuelling the need for efficient algorithms for sequence compression and analysis. Data compression and the associated techniques coming from information…

Data Structures and Algorithms · Computer Science 2011-09-05 Heba Afify , Muhammad Islam , Manal Abdel Wahed