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We investigate pores in fluid membranes by molecular dynamics simulations of an amphiphile-solvent mixture, using a molecular coarse-grained model. The amphiphilic membranes self-assemble into a lamellar stack of amphiphilic bilayers…

Soft Condensed Matter · Physics 2009-11-11 Claire Loison , Michel Mareschal , Friederike Schmid

According to the lipid raft hypothesis, biological lipid membranes are laterally heterogeneous and filled with nanoscale ordered "raft" domains, which are believed to play an important role for the organization of proteins in membranes.…

Biological Physics · Physics 2013-03-22 Sebastian Meinhardt , Richard L. C. Vink , Friederike Schmid

The bending rigidity $k_c$ of bilayer vesicles self-assembled from amphiphilic diblock copolymers has been measured using single and dual-micropipet techniques. These copolymers are nearly a factor of 5 greater in hydrophobic membrane…

Soft Condensed Matter · Physics 2007-05-23 H. Bermudez , D. A. Hammer , D. E. Discher

We propose a model that accounts for budding behavior of domains in lipid bilayers, where each of the bilayer leaflets has a coupling between its local curvature and local lipid composition. The compositional asymmetry between the two…

Soft Condensed Matter · Physics 2015-03-31 Jean Wolff , Shigeyuki Komura , David Andelman

We summarize and compare recent Molecular Dynamics simulations on the interactions of dipalmitoylphosphatidylcholine (DPPC) bilayers in the liquid crystalline phase with a number of small molecules including trehalose, a disaccharide of…

Biological Physics · Physics 2007-05-23 Bryan W. Lee , Roland Faller , Amadeu K. Sum , Ilpo Vattulainen , Michael Patra , Mikko Karttunen

The adhesion bonds connecting a lipid bilayer to an underlying surface may undergo a condensation transition resulting from an interplay between a short range attractive potential between them, and a long range fluctuation-induced potential…

Soft Condensed Matter · Physics 2016-02-25 Nadiv Dharan , Oded Farago

We extend previous work on homogeneous bilayers to calculate the barriers to fusion of planar bilayers which contain two different amphiphiles, a lamellae-former and a hexagonal former, with different compositions of the twoin each leaf.…

Soft Condensed Matter · Physics 2009-11-11 Jae Youn Lee , Michael Schick

We investigate spinodal decomposition and structuring effects in binary immiscible and ternary amphiphilic fluid mixtures under shear by means of three dimensional lattice Boltzmann simulations. We show that the growth of individual fluid…

Soft Condensed Matter · Physics 2007-05-23 Jens Harting , Giovanni Giupponi , Peter V. Coveney

It was recently discovered that friction between surfaces bearing phosphatidylcholine (PC) lipid bilayers can be increased by two orders of magnitude or more via an externally-applied electric field, and that this increase is fully…

Soft Condensed Matter · Physics 2024-09-26 Di Jin , Jacob Klein

A problem of great concern in aviation and submarine propulsion is the control of the boundary layer and, in particular, the methods to extend the laminar region as a means to decrease noise and fuel consumption. In this paper we study the…

Fluid Dynamics · Physics 2008-02-03 R. Vilela Mendes , J. A. Dente

Plasma membranes appear as deformable systems wherein molecules are free to move and diffuse giving rise to condensed microdomains (composed of ordered lipids, transmembrane proteins and cholesterol) surrounded by disordered lipid…

Soft Condensed Matter · Physics 2024-09-25 Chiara Bernard , Angelo Rosario Carotenuto , Nicola Maria Pugno , Luca Deseri , Massimiliano Fraldi

We theoretically investigate the relaxation dynamics of a nearly-flat binary lipid bilayer membrane by taking into account the membrane tension, hydrodynamics of the surrounding fluid, inter-monolayer friction and mutual diffusion in each…

Soft Condensed Matter · Physics 2016-05-05 Ryuichi Okamoto , Yuichi Kanemori , Shigeyuki Komura , Jean-Baptiste Fournier

The elastic properties of two-component bilayer membranes are studied using a coarse grain model for amphiphilic molecules. The two species of amphiphiles considered here differ only in their length. Molecular Dynamics simulations are…

Soft Condensed Matter · Physics 2007-05-23 Alberto Imparato , Julian C. Shillcock , Reinhard Lipowsky

This article summarizes a variety of physical mechanisms proposed in the literature, which can generate micro- and nanodomains in multicomponent lipid bilayers and biomembranes. It mainly focusses on lipid-driven mechanisms that do not…

Biological Physics · Physics 2016-11-16 Friederike Schmid

The domain formation of curvature-inducing molecules, such as peripheral or transmembrane proteins and conical surfactants, is studied in thermal equilibrium and nonequilibrium steady states using meshless membrane simulations. These…

Soft Condensed Matter · Physics 2023-01-30 Hiroshi Noguchi

The phase separation of a two-dimensional active binary mixture is studied under the action of an applied shear through numerical simulations. It is highlighted how the strength of the external flow modifies the initial shape of growing…

Soft Condensed Matter · Physics 2021-12-01 A. Lamura , A. Tiribocchi

The organization of lipids in biological membranes is essential for cellular functions such as signal transduction and membrane trafficking. A major challenge is how to control lateral lipid composition in supported membranes which are…

Soft Condensed Matter · Physics 2016-08-31 Qing Liang , Yu-qiang Ma

We study a model lipid bilayer composed of a mixture of two incompatible lipid types which have a natural tendency to segregate in the absence of membrane fluctuations. The membrane is mechanically characterized by a local bending rigidity…

Soft Condensed Matter · Physics 2007-05-23 D. S. Dean , M. Manghi

Membrane organization is essential for cellular functions such as signal transduction and membrane trafficking. A major challenge is to understand the lateral heterogeneous structures in membranes and membrane fluidity in the presence of…

Soft Condensed Matter · Physics 2007-11-09 Chun-Lai Ren , Yu-qiang Ma

The hydration layer surrounding the phosphocholine headgroups of single-component phosphatidylcholine (PC) lipids, or of lipid-mixtures, assembled at an interface greatly modifies the interfacial properties and interactions. As water…

Soft Condensed Matter · Physics 2022-04-27 Yifeng Cao , Jacob Klein