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Enzyme is the major workhorse to carry out the diverse cellular functions. It catalyzes the biological reactions with a high specificity, with its topology playing a crucial role. For ecologically safe production of numerous bioproducts…

Biomolecules · Quantitative Biology 2021-06-04 Prabha Sankara Narayanan , Ashish Runthala

Conventional multimedia annotation/retrieval systems such as Normalized Continuous Relevance Model (NormCRM) [16] require a fully labeled training data for a good performance. Active Learning, by determining an order for labeling the…

Multimedia · Computer Science 2015-04-28 Moitreya Chatterjee , Anton Leuski

The scoring function, which measures the plausibility of triplets in knowledge graphs (KGs), is the key to ensure the excellent performance of KG embedding, and its design is also an important problem in the literature. Automated machine…

Machine Learning · Computer Science 2021-04-23 Shimin Di , Quanming Yao , Yongqi Zhang , Lei Chen

Rank similarity measures provide a method for quantifying differences between search engine results without the need for relevance judgments. For example, the providers of a search service might use such measures to estimate the impact of a…

Information Retrieval · Computer Science 2014-08-18 Luchen Tan , Clarke L. A. Clarke

Educational data mining (EDM) is a new growing research area and the essence of data mining concepts are used in the educational field for the purpose of extracting useful information on the behaviors of students in the learning process. In…

Databases · Computer Science 2009-12-22 M. Ramaswami , R. Bhaskaran

Causal relation extraction of biomedical entities is one of the most complex tasks in biomedical text mining, which involves two kinds of information: entity relations and entity functions. One feasible approach is to take relation…

Computation and Language · Computer Science 2022-08-03 Dongling Li , Pengchao Wu , Yuehu Dong , Jinghang Gu , Longhua Qian , Guodong Zhou

Entity linking (or Normalization) is an essential task in text mining that maps the entity mentions in the medical text to standard entities in a given Knowledge Base (KB). This task is of great importance in the medical domain. It can also…

Computation and Language · Computer Science 2020-12-22 Ishani Mondal , Sukannya Purkayastha , Sudeshna Sarkar , Pawan Goyal , Jitesh Pillai , Amitava Bhattacharyya , Mahanandeeshwar Gattu

This paper presents a Kernel Entity Salience Model (KESM) that improves text understanding and retrieval by better estimating entity salience (importance) in documents. KESM represents entities by knowledge enriched distributed…

Information Retrieval · Computer Science 2018-05-04 Chenyan Xiong , Zhengzhong Liu , Jamie Callan , Tie-Yan Liu

Linking networks of molecular interactions to cellular functions and phenotypes is a key goal in systems biology. Here, we adapt concepts of spatial statistics to assess the functional content of molecular networks. Based on the…

Molecular Networks · Quantitative Biology 2015-06-22 Alex J. Cornish , Florian Markowetz

The majority of Semantic Web search engines retrieve information by focusing on the use of concepts and relations restricted to the query provided by the user. By trying to guess the implicit meaning between these concepts and relations,…

Information Retrieval · Computer Science 2012-11-28 Manuel Rojas

Clinical diagnosis guidelines aim at specifying the steps that may lead to a diagnosis. Inspired by guidelines, we aim to learn the optimal sequence of actions to perform in order to obtain a correct diagnosis from electronic health…

Machine Learning · Computer Science 2023-11-16 Lillian Muyama , Antoine Neuraz , Adrien Coulet

Predicting enzyme-substrate interactions has long been a fundamental problem in biochemistry and metabolic engineering. While existing methods could leverage databases of expert-curated enzyme-substrate pairs for models to learn from known…

Artificial Intelligence · Computer Science 2026-01-12 Tengwei Song , Long Yin , Zhen Han , Zhiqiang Xu

We propose a family of very efficient hierarchical indexing schemes for ungapped, score matrix-based similarity search in large datasets of short (4-12 amino acid) protein fragments. This type of similarity search has importance in both…

Data Structures and Algorithms · Computer Science 2007-09-04 Aleksandar Stojmirovic , Vladimir Pestov

As experimental efforts are costly and time consuming, computational characterization of enzyme capabilities is an attractive alternative. We present and evaluate several machine-learning models to predict which of 983 distinct enzymes, as…

Cell Behavior · Quantitative Biology 2021-01-27 Gian Marco Visani , Michael C. Hughes , Soha Hassoun

Joinable Column Discovery is a critical challenge in automating enterprise data analysis. While existing approaches focus on syntactic overlap and semantic similarity, there remains limited understanding of which methods perform best for…

Semantic annotation, the process of identifying key-phrases in texts and linking them to concepts in a knowledge base, is an important basis for semantic information retrieval and the Semantic Web uptake. Despite the emergence of semantic…

Computation and Language · Computer Science 2018-11-15 Gagnon Michel , Zouaq Amal , Aranha Francisco , Ensan Faezeh , Jean-Louis Ludovic

In recent years, deep metric learning has achieved promising results in learning high dimensional semantic feature embeddings where the spatial relationships of the feature vectors match the visual similarities of the images. Similarity…

Machine Learning · Computer Science 2019-09-25 Konstantin Schall , Kai Uwe Barthel , Nico Hezel , Klaus Jung

In retrieval-augmented systems, context ranking techniques are commonly employed to reorder the retrieved contexts based on their relevance to a user query. A standard approach is to measure this relevance through the similarity between…

Information Retrieval · Computer Science 2024-10-22 Weichao Zhou , Jiaxin Zhang , Hilaf Hasson , Anu Singh , Wenchao Li

Semantic segmentation of polyps and depth estimation are two important research problems in endoscopic image analysis. One of the main obstacles to conduct research on these research problems is lack of annotated data. Endoscopic…

Computer Vision and Pattern Recognition · Computer Science 2022-04-08 Shrawan Kumar Thapa , Pranav Poudel , Binod Bhattarai , Danail Stoyanov

Ranking consistently emerges as a primary focus in information retrieval research. Retrieval and ranking models serve as the foundation for numerous applications, including web search, open domain QA, enterprise domain QA, and text-based…

Information Retrieval · Computer Science 2024-12-16 Hansa Meghwani