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In adaptive clinical trials, the conventional end-of-trial point estimate of a treatment effect is prone to bias, that is, a systematic tendency to deviate from its true value. As stated in recent FDA guidance on adaptive designs, it is…

The outcomes of elections, product sales, and the structure of social connections are all determined by the choices individuals make when presented with a set of options, so understanding the factors that contribute to choice is crucial. Of…

Machine Learning · Computer Science 2020-11-09 Kiran Tomlinson , Austin R. Benson

Theoretical guarantees for causal inference using propensity scores are partly based on the scores behaving like conditional probabilities. However, scores between zero and one, especially when outputted by flexible statistical estimators,…

Methodology · Statistics 2024-11-12 Rom Gutman , Ehud Karavani , Yishai Shimoni

Given a family of pretrained models and a hold-out set, how can we construct a valid conformal prediction set while selecting a model that minimizes the width of the set? If we use the same hold-out data set both to select a model (the…

Methodology · Statistics 2026-04-20 Ruiting Liang , Wanrong Zhu , Rina Foygel Barber

In clinical settings, we often face the challenge of building prediction models based on small observational data sets. For example, such a data set might be from a medical center in a multi-center study. Differences between centers might…

The possibility of strong biases in a multicomponent Maximum Likelihood fits with component-dependent templates has been demonstrated in some toy problems. We discuss here in detail a problem of practical interest, particle identification…

Data Analysis, Statistics and Probability · Physics 2017-08-23 P. Catastini , G. Punzi

One fundamental statistical question for research areas such as precision medicine and health disparity is about discovering effect modification of treatment or exposure by observed covariates. We propose a semiparametric framework for…

Methodology · Statistics 2020-08-04 Muxuan Liang , Menggang Yu

We distinguish two questions (i) how much information does the prior contain? and (ii) what is the effect of the prior? Several measures have been proposed for quantifying effective prior sample size, for example Clarke [1996] and Morita et…

Methodology · Statistics 2020-01-30 David E Jones , Robert N Trangucci , Yang Chen

We consider inference on a scalar regression coefficient under a constraint on the magnitude of the control coefficients. A class of estimators based on a regularized propensity score regression is shown to exactly solve a tradeoff between…

Econometrics · Economics 2023-08-11 Timothy B. Armstrong , Michal Kolesár , Soonwoo Kwon

We study the problem of selecting covariates for unbiased estimation of the total causal effect.Existing approaches typically rely on global causal structure learning over all variables, or on strong assumptions such as causal sufficiency -…

Machine Learning · Statistics 2026-05-22 Zeyu Liu , Zheng Li , Feng Xie , Yan Zeng , Hao Zhang , Kun Zhang

Selection bias is a serious potential problem for inference about relationships of scientific interest based on samples without well-defined probability sampling mechanisms. Motivated by the potential for selection bias in (a) estimated…

We provide an approach to exploratory data analysis in matched observational studies with a single intervention and multiple endpoints. In such settings, the researcher would like to explore evidence for actual treatment effects among these…

Methodology · Statistics 2025-12-10 Mengqi Lin , Colin Fogarty

Selectivity estimation aims at estimating the number of database objects that satisfy a selection criterion. Answering this problem accurately and efficiently is essential to many applications, such as density estimation, outlier detection,…

Databases · Computer Science 2021-05-28 Yaoshu Wang , Chuan Xiao , Jianbin Qin , Rui Mao , Onizuka Makoto , Wei Wang , Rui Zhang , Yoshiharu Ishikawa

The additive genetic effect is arguably the most important quantity inferred in animal and plant breeding analyses. The term effect indicates that it represents causal information, which is different from standard statistical concepts as…

Quantitative Methods · Quantitative Biology 2015-04-27 Bruno Dourado Valente , Gota Morota , Guilherme Jordao Magalhaes Rosa , Daniel Gianola , Kent Weigel

One of the most fundamental problems in causal inference is the estimation of a causal effect when variables are confounded. This is difficult in an observational study, because one has no direct evidence that all confounders have been…

Machine Learning · Statistics 2014-11-03 Ricardo Silva , Robin Evans

In unsupervised ensemble learning, one obtains predictions from multiple sources or classifiers, yet without knowing the reliability and expertise of each source, and with no labeled data to assess it. The task is to combine these possibly…

Machine Learning · Computer Science 2016-02-24 Ariel Jaffe , Ethan Fetaya , Boaz Nadler , Tingting Jiang , Yuval Kluger

Optimizing recommender systems based on user interaction data is mainly seen as a problem of dealing with selection bias, where most existing work assumes that interactions from different users are independent. However, it has been shown…

Information Retrieval · Computer Science 2022-07-04 Norman Knyazev , Harrie Oosterhuis

The estimation of causal treatment effects from observational data is a fundamental problem in causal inference. To avoid bias, the effect estimator must control for all confounders. Hence practitioners often collect data for as many…

Machine Learning · Statistics 2020-11-05 Kristjan Greenewald , Dmitriy Katz-Rogozhnikov , Karthik Shanmugam

Accurate estimation for extent of cross{sectional dependence in large panel data analysis is paramount to further statistical analysis on the data under study. Grouping more data with weak relations (cross{sectional dependence) together…

Econometrics · Economics 2019-04-16 Jiti Gao , Guangming Pan , Yanrong Yang , Bo Zhang

The widespread adoption of generative AI models has raised growing concerns about representational harm and potential discriminatory outcomes. Yet, despite growing literature on this topic, the mechanisms by which bias emerges - especially…

Computer Vision and Pattern Recognition · Computer Science 2025-06-12 Xiaofeng Zhang , Michelle Lin , Simon Lacoste-Julien , Aaron Courville , Yash Goyal