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In evolutionary studies it is common to use phylogenetic trees to represent the evolutionary history of a set of species. However, in case the transfer of genes or other genetic information between the species or their ancestors has…

Combinatorics · Mathematics 2022-02-15 Katharina T. Huber , Vincent Moulton , Guillaume E. Scholz

Reconstructing evolutionary trees from molecular sequence data is a fundamental problem in computational biology. Stochastic models of sequence evolution are closely related to spin systems that have been extensively studied in statistical…

Probability · Mathematics 2017-07-20 Sebastien Roch , Allan Sly

Species tree reconstruction from genomic data is increasingly performed using methods that account for sources of gene tree discordance such as incomplete lineage sorting. One popular method for reconstructing species trees from unrooted…

Populations and Evolution · Quantitative Biology 2017-12-06 Shubhanshu Shekhar , Sebastien Roch , Siavash Mirarab

The supertree problem asking for a tree displaying a set of consistent input trees has been largely considered for the reconstruction of species trees. Here, we rather explore this framework for the sake of reconstructing a gene tree from a…

Data Structures and Algorithms · Computer Science 2016-10-25 Manuel Lafond , Cédric Chauve , Nadia El-Mabrouk , Aïda Ouangraoua

An important problem in evolutionary biology is to reconstruct the evolutionary history of a set $X$ of species. This history is often represented as a phylogenetic network, that is, a connected graph with leaves labelled by elements in $X$…

Combinatorics · Mathematics 2017-02-01 Leo van Iersel , Vincent Moulton

The history of gene families -- which are equivalent to event-labeled gene trees -- can to some extent be reconstructed from empirically estimated evolutionary event-relations containing pairs of orthologous, paralogous or xenologous genes.…

Discrete Mathematics · Computer Science 2019-10-30 Manuel Lafond , Marc Hellmuth

Phylogenetic inference can potentially result in a more accurate tree using data from multiple loci. However, if the loci are incongruent--due to events such as incomplete lineage sorting or horizontal gene transfer--it can be misleading to…

Populations and Evolution · Quantitative Biology 2016-03-10 Kevin Gori , Tomasz Suchan , Nadir Alvarez , Nick Goldman , Christophe Dessimoz

Phylogenetic network is an evolutionary model that uses a rooted directed acyclic graph (instead of a tree) to model an evolutionary history of species in which reticulate events (e.g., hybrid speciation or horizontal gene transfer)…

Populations and Evolution · Quantitative Biology 2023-12-01 Yufeng Wu , Louxin Zhang

Phylogenetic inference, the task of reconstructing how related sequences evolved from common ancestors, is a central objective in evolutionary genomics. The current state-of-the-art methods exploit probabilistic models of sequence evolution…

Populations and Evolution · Quantitative Biology 2026-02-19 Luc Blassel , Noémie Sauvage , Pierre Barrat-Charlaix , Bastien Boussau , Nicolas Lartillot , Laurent Jacob

Distance-based approaches in phylogenetics such as Neighbor-Joining are a fast and popular approach for building trees. These methods take pairs of sequences from them construct a value that, in expectation, is additive under a stochastic…

Populations and Evolution · Quantitative Biology 2008-08-21 Mike Steel

Most of major algorithms for phylogenetic tree reconstruction assume that sequences in the analyzed set either do not have any offspring, or that parent sequences can maximally mutate into just two descendants. The graph resulting from such…

Populations and Evolution · Quantitative Biology 2013-10-09 Piotr Plonski , Jan P. Radomski

Phylogenomics heavily relies on well-curated sequence data sets that consist, for each gene, exclusively of 1:1-orthologous. Paralogs are treated as a dangerous nuisance that has to be detected and removed. We show here that this severe…

Discrete Mathematics · Computer Science 2017-12-19 Marc Hellmuth , Nicolas Wieseke , Marcus Lechner , Hans-Peter Lenhof , Martin Middendorf , Peter F. Stadler

The multispecies coalescent process models the genealogical relationships of genes sampled from several species, enabling useful predictions about phenomena such as the discordance between the gene tree and the species phylogeny due to…

Populations and Evolution · Quantitative Biology 2020-12-11 Jakub Truszkowski , Celine Scornavacca , Fabio Pardi

Summary: Both theory and empirical evidence indicate that phylogenies (trees) of different genes (loci) do not display precisely matched topologies. This phylogenetic incongruence is attributed to the reticulated evolutionary history of…

Populations and Evolution · Quantitative Biology 2016-01-01 Ruriko Yoshida , Kenji Fukumizu , Chrysafis Vogiatzis

Typing methods are widely used in the surveillance of infectious diseases, outbreaks investigation and studies of the natural history of an infection. And their use is becoming standard, in particular with the introduction of High…

Data Structures and Algorithms · Computer Science 2020-06-16 Cátia Vaz , Marta Nascimento , João A. Carriço , Tatiana Rocher , Alexandre P. Francisco

Reconciling gene trees with a species tree is a fundamental problem to understand the evolution of gene families. Many existing approaches reconcile each gene tree independently. However, it is well-known that the evolution of gene families…

Populations and Evolution · Quantitative Biology 2018-06-12 Riccardo Dondi , Manuel Lafond , Celine Scornavacca

Phylogenetic networks are necessary to represent the tree of life expanded by edges to represent events such as horizontal gene transfers, hybridizations or gene flow. Not all species follow the paradigm of vertical inheritance of their…

Populations and Evolution · Quantitative Biology 2016-02-15 Claudia Solís-Lemus , Cécile Ané

It is common in phylogenetics to have some, perhaps partial, information about the overall evolutionary tree of a group of organisms and wish to find an evolutionary tree of a specific gene for those organisms. There may not be enough…

Populations and Evolution · Quantitative Biology 2018-01-09 Vu Dinh , Lam Si Tung Ho , Marc A. Suchard , Frederick A. Matsen

A major problem for inferring species trees from gene trees is that evolutionary processes can sometimes favour gene tree topologies that conflict with an underlying species tree. In the case of incomplete lineage sorting, this phenomenon…

Populations and Evolution · Quantitative Biology 2012-12-03 Mike Steel , Simone Linz , Daniel H. Huson , Michael J. Sanderson

We propose a novel method for the inference of phylogenetic trees that utilises point configurations on hyperbolic space as its optimisation landscape. Each taxon corresponds to a point of the point configuration, while the evolutionary…

Machine Learning · Computer Science 2021-06-07 Benjamin Wilson