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Biological cells can actively tune their intracellular architecture according to their overall shape. Here we explore the rheological implication of such coupling in a minimal model of a dense cellular material where each cell exerts an…

Soft Condensed Matter · Physics 2022-04-13 Shao-Zhen Lin , Matthias Merkel , Jean-François Rupprecht

Micropatterned substrates are often used to standardize cell experiments and to quantitatively study the relation between cell shape and function. Moreover, they are increasingly used in combination with traction force microscopy on soft…

Cell Behavior · Quantitative Biology 2015-06-19 Philipp J. Albert , Ulrich S. Schwarz

Mechanical metamaterials leverage geometric design to achieve unconventional properties, such as high strength at low density, efficient wave guiding, and complex shape morphing. The ability to control shape changes builds on the complex…

Applied Physics · Physics 2025-01-28 Krzysztof K. Dudek , Muamer Kadic , Corentin Coulais , Katia Bertoldi

Strong coupling between molecules and quantized fields has emerged as an effective methodology to engineer molecular properties. New hybrid states are formed when molecules interact with quantized fields. Since the properties of these…

Chemical Physics · Physics 2023-06-28 Marco Romanelli , Rosario R. Riso , Tor S. Haugland , Enrico Ronca , Stefano Corni , Henrik Koch

The development of traction-force microscopy, in the past two decades, has created the unprecedented opportunity of performing direct mechanical measurements on living cells as they adhere or crawl on uniform or micro-patterned substrates.…

Biological Physics · Physics 2019-10-25 Luca Giomi

Traditional top-down robotic design often lacks the adaptability needed to handle real-world complexities, prompting the need for more flexible approaches. Therefore, this study introduces a novel cellular plasticity model tailored for…

Robotics · Computer Science 2024-08-13 Trevor R. Smith , Thomas J. Smith , Nicholas S. Szczecinski , Sergiy Yakovenko , Yu Gu

Substrate-based cell motility is essential for fundamental biological processes, such as tissue growth, wound healing and immune response. Even if a comprehensive understanding of this motility mode remains elusive, progress has been…

Cell Behavior · Quantitative Biology 2016-05-23 Wieland Marth , Axel Voigt

Inspired by natural cellular materials such as trabecular bone, lattice structures have been developed as a new type of lightweight material. In this paper we present a novel method to design lattice structures that conform with both the…

Computational Engineering, Finance, and Science · Computer Science 2019-09-06 Jun Wu , Weiming Wang , Xifeng Gao

Particles with directional interactions are promising building blocks for new functional materials and may serve as models for biological structures. Mutually attractive nanoparticles that are deformable due to flexible surface groups, for…

Soft Condensed Matter · Physics 2016-07-19 Chris H. J. Evers , Jurriaan A. Luiken , Peter G. Bolhuis , Willem K. Kegel

Plants are a paradigm for active shape control in response to stimuli. For instance, it is well-known that a tilted plant will eventually straighten vertically, demonstrating the influence of both an external stimulus, gravity, and an…

Biological Physics · Physics 2025-09-09 Hadrien Oliveri , Derek E. Moulton , Heather A. Harrington , Alain Goriely

Everyday experience shows that cellular sheets are stiffened by the presence of a pressurized gas: from bicycle inner tubes to bubble wrap, the presence of an internal pressure increases the stiffness of otherwise floppy structures. The…

Cell motility in dense cell collectives is pivotal in various diseases like cancer metastasis and asthma. A central aspect in these phenomena is the heterogeneity in cell motility, but identifying the motility of individual cells is…

How do cells tune emergent properties at the scale of tissues? One class of such emergent behaviors are rigidity transitions, in which a tissue changes from a solid-like to a fluid-like state or vice versa. Here, we introduce a new way for…

Soft Condensed Matter · Physics 2025-06-04 Sadjad Arzash , Indrajit Tah , Andrea J. Liu , M. Lisa Manning

Modeling membrane interactions with arbitrarily shaped colloidal particles, such as environmental micro- and nanoplastics, at the cell scale remains particularly challenging, owing to the complexity of particle geometries and the need to…

Soft Condensed Matter · Physics 2025-09-15 Didarul Ahasan Redwan , Justin Reicher , Xin Yong

This study aims at finding a method for constructing molecular dynamics like models using the formalism of cellular automata for fast simulation of fluid dynamic systems (including compressible phenomena). In as much as the results…

comp-gas · Physics 2009-09-25 Himanshu Agrawal

This work deals with the portability of greenhouse models, as we believe that this is a challenge to their practical usage in control strategies under production conditions. We address this task by means of adaptive neural networks, which…

Other Computer Science · Computer Science 2019-08-13 Luis Miranda , Guido Schillaci

A model of multicellular systems with several types of cells is developed from the phase field model. The model is presented as a set of partial differential equations of the field variables, each of which expresses the shape of one cell.…

Biological Physics · Physics 2015-05-30 Makiko Nonomura

Collective cell migration plays a central role in tissue development, morphogenesis, wound repair and cancer progression. With the growing realization that physical forces mediate cell motility in development and physiology, a key…

Biological Physics · Physics 2018-12-07 Shiladitya Banerjee , M. Cristina Marchetti

Inspired by the quest for shape-shifting structures in a range of applications, we show how to create morphable structural materials using a neutrally stable unit cell as a building block. This unit cell is a self-stressed hinged structure…

Soft Condensed Matter · Physics 2021-10-18 Gaurav Chaudhary , S Ganga Prasath , Edward Soucy , L Mahadevan

The transport of motile entities across modulated energy landscapes plays an important role in a range of phenomena in biology, colloidal science and solid-state physics. Here, an easily implementable strategy that allows for the collective…

Soft Condensed Matter · Physics 2020-03-11 Fernando Martínez-Pedrero , Francisco Ortega , Ramón G. Rubio , Carles Calero