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Related papers: A Logical Framework for Systems Biology

200 papers

The requirements engineering (RE) phase is pivotal in developing high-quality software. Integrating advanced modelling techniques with large language models (LLMs) and formal verification in a logical style can significantly enhance this…

Software Engineering · Computer Science 2025-06-11 Radoslaw Klimek

This paper presents a probabilistic model validation methodology for nonlinear systems in time-domain. The proposed formulation is simple, intuitive, and accounts both deterministic and stochastic nonlinear systems with parametric and…

Systems and Control · Computer Science 2014-02-04 Abhishek Halder , Raktim Bhattacharya

Different theorem provers tend to produce proof objects in different formats and this is especially the case for modal logics, where several deductive formalisms (and provers based on them) have been presented. This work falls within the…

Logic in Computer Science · Computer Science 2016-09-15 Tomer Libal , Marco Volpe

Verification of temporal logic properties plays a crucial role in proving the desired behaviors of hybrid systems. In this paper, we propose an interval method for verifying the properties described by a bounded linear temporal logic. We…

Logic in Computer Science · Computer Science 2015-07-15 Daisuke Ishii , Naoki Yonezaki , Alexandre Goldsztejn

We present a unifying framework for type systems for process calculi. The core of the system provides an accurate correspondence between essentially functional processes and linear logic proofs; fragments of this system correspond to…

Logic in Computer Science · Computer Science 2015-05-29 Emmanuel Beffara

The interplay between process behaviour and spatial aspects of computation has become more and more relevant in Computer Science, especially in the field of collective adaptive systems, but also, more generally, when dealing with systems…

Logic in Computer Science · Computer Science 2014-06-27 Vincenzo Ciancia , Diego Latella , Michele Loreti , Mieke Massink

We introduce a logical framework for the specification and verification of component-based systems, in which finitely many component instances are active, but the bound on their number is not known. Besides specifying and verifying…

Logic in Computer Science · Computer Science 2019-08-30 Marius Bozga , Radu Iosif , Joseph Sifakis

Many embedded and real-time systems have a inherent probabilistic behaviour (sensors data, unreliable hardware,...). In that context, it is crucial to evaluate system properties such as "the probability that a particular hardware fails".…

Software Engineering · Computer Science 2015-09-22 Van Chan Ngo , Axel Legay , Jean Quilbeuf

Common programming tools, like compilers, debuggers, and IDEs, crucially rely on the ability to analyse program code to reason about its behaviour and properties. There has been a great deal of work on verifying compilers and static…

Programming Languages · Computer Science 2019-07-15 Jan Stolarek , James Cheney

A dynamic logic method was developed to analyze molecular networks of cells by combining Kauffman and Thomas's logic operations with molecular interaction parameters. The logic operations characterize the discrete interactions between…

Quantitative Methods · Quantitative Biology 2008-06-11 Suping Lyu

Autonomous systems embedded with machine learning modules often rely on deep neural networks for classifying different objects of interest in the environment or different actions or strategies to take for the system. Due to the…

Systems and Control · Electrical Eng. & Systems 2020-04-07 Zhe Xu

We propose a static and a dynamic approach to model biological signaling networks, and show how each can be used to answer relevant biological questions. For this we use the two different mathematical tools of Propositional Logic and…

Quantitative Methods · Quantitative Biology 2009-05-13 Utz-Uwe Haus , Kathrin Niermann , Klaus Truemper , Robert Weismantel

Search-based testing is widely used to find bugs in models of complex Cyber-Physical Systems. Latest research efforts have improved this approach by casting it as a falsification procedure of formally specified temporal properties,…

Logic in Computer Science · Computer Science 2017-10-03 Simone Silvetti , Alberto Policriti , Luca Bortolussi

This thesis concerns the development of a framework that facilitates the design and analysis of formal systems. Specifically, this framework provides a specification language which supports the concise and direct description of formal…

Logic in Computer Science · Computer Science 2009-10-06 Andrew Gacek

A modeling formalism is proposed for the description and study of living and life-like systems. It provides an abstract conceptual model framework for real life and evolution of biological organisms. It is proposed, that this model…

Populations and Evolution · Quantitative Biology 2013-06-14 Margareta Segerståhl

In this position paper, we propose a reasoning framework that can model the reasoning process underlying natural language inferences. The framework is based on the semantic tableau method, a well-studied proof system in formal logic. Like…

Computation and Language · Computer Science 2025-02-10 Lasha Abzianidze

Robotic cell injection is used for automatically delivering substances into a cell and is an integral component of drug development, genetic engineering and many other areas of cell biology. Traditionally, the correctness of functionality…

Logic in Computer Science · Computer Science 2018-07-20 Adnan Rashid , Osman Hasan

This paper combines the classical model of labeled transition systems with the epistemic model for reasoning about knowledge. The result is a unifying framework for modeling and analyzing multi-agent, knowledge-based, dynamic systems. On…

Artificial Intelligence · Computer Science 2025-12-03 Alessandro Aldini

The molecular computing has been successfully employed to solve more and more complex computation problems. However, as an important complex problem, the model checking are still far from fully resolved under the circumstance of molecular…

Logic in Computer Science · Computer Science 2017-02-21 Weijun Zhu

Modern software systems are often realized by coordinating multiple heterogeneous parts, each responsible for specific tasks. These parts must work together seamlessly to satisfy the overall system requirements. To verify such complex…

Software Engineering · Computer Science 2025-08-19 Tim Kräuter , Adrian Rutle , Yngve Lamo , Harald König , Francisco Durán