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Regression methods dominate the practice of biostatistical analysis, but biostatistical training emphasises the details of regression models and methods ahead of the purposes for which such modelling might be useful. More broadly,…

Methodology · Statistics 2024-09-12 John B. Carlin , Margarita Moreno-Betancur

We introduce and motivate generative modeling as a central task for machine learning and provide a critical view of the algorithms which have been proposed for solving this task. We overview how generative modeling can be defined…

Machine Learning · Computer Science 2021-03-02 Alex Lamb

Understanding how the brain encodes stimuli has been a fundamental problem in computational neuroscience. Insights into this problem have led to the design and development of artificial neural networks that learn representations by…

Neurons and Cognition · Quantitative Biology 2025-12-04 Shubham Choudhary , Paul Masset , Demba Ba

Genetic sequences are known to possess non-trivial composition together with symmetries in the frequencies of their components. Recently, it has been shown that symmetry and structure are hierarchically intertwined in DNA, suggesting a…

Genomics · Quantitative Biology 2020-09-28 Giampaolo Cristadoro , Mirko Degli Esposti , Eduardo G. Altmann

Understanding the pattern formation in communities has been at the center of attention in various fields. Here we introduce a novel model, called an "information-particle model," which is based on the reaction-diffusion model and the…

Physics and Society · Physics 2023-07-21 Junichi Miyakoshi

How do mammalian cells that share the same genome exist in notably distinct phenotypes, exhibiting differences in morphology, gene expression patterns, and epigenetic chromatin statuses? Furthermore how do cells of different phenotypes…

Molecular Networks · Quantitative Biology 2015-04-27 Jianhua Xing , Jin Yu , Hang Zhang , Xiao-Jun Tian

Network neuroscience is the emerging discipline concerned with investigating the complex patterns of interconnections found in neural systems, and to identify principles with which to understand them. Within this discipline, one…

Neurons and Cognition · Quantitative Biology 2017-08-29 Richard F. Betzel , Danielle S. Bassett

Compartmental epidemic models have been widely used for predicting the course of epidemics, from estimating the basic reproduction number to guiding intervention policies. Studies commonly acknowledge these models' assumptions but less…

Populations and Evolution · Quantitative Biology 2022-11-23 Alexander F. Siegenfeld , Pratyush K. Kollepara , Yaneer Bar-Yam

Many biological phenomena such as locomotion, circadian cycles, and breathing are rhythmic in nature and can be modeled as rhythmic dynamical systems. Dynamical systems modeling often involves neglecting certain characteristics of a…

Dynamical Systems · Mathematics 2016-01-20 M. Mert Ankaralı , Shahin Sefati , Manu S. Madhav , Andrew Long , Amy J. Bastian , Noah J. Cowan

Developing deep generative models has been an emerging field due to the ability to model and generate complex data for various purposes, such as image synthesis and molecular design. However, the advancement of deep generative models is…

Deep generative models have significantly advanced medical imaging analysis by enhancing dataset size and quality. Beyond mere data augmentation, our research in this paper highlights an additional, significant capacity of deep generative…

Computer Vision and Pattern Recognition · Computer Science 2024-10-18 Xiaodan Xing , Junzhi Ning , Yang Nan , Guang Yang

Large monolithic generative models trained on massive amounts of data have become an increasingly dominant approach in AI research. In this paper, we argue that we should instead construct large generative systems by composing smaller…

Machine Learning · Computer Science 2024-06-05 Yilun Du , Leslie Kaelbling

We discuss several aspects of creation of adequate mathematical models in other sciences. In particular, many difficulties stem from great complexity of the source systems and the presence of a variety of uncertain factors. We illustrate…

Optimization and Control · Mathematics 2021-02-19 I. V. Konnov

We propose a novel approach for using unsupervised boosting to create an ensemble of generative models, where models are trained in sequence to correct earlier mistakes. Our meta-algorithmic framework can leverage any existing base learner…

Machine Learning · Computer Science 2017-12-25 Aditya Grover , Stefano Ermon

Numerous works have noted similarities in how machine learning models represent the world, even across modalities. Although much effort has been devoted to uncovering properties and metrics on which these models align, surprisingly little…

Machine Learning · Computer Science 2025-09-30 Zeyu Michael Li , Hung Anh Vu , Damilola Awofisayo , Emily Wenger

The modeling of time series is becoming increasingly critical in a wide variety of applications. Overall, data evolves by following different patterns, which are generally caused by different user behaviors. Given a time series, we define…

Machine Learning · Computer Science 2022-07-13 Wenjie Hu , Jianping Huang , Liang Wu , Yang Yang , Zongtao Liu , Zhanlin Sun , Bingshen Yao , Ke Chen

Recent research has shown that generative models with highly disentangled representations fail to generalise to unseen combination of generative factor values. These findings contradict earlier research which showed improved performance in…

Machine Learning · Computer Science 2024-06-17 Milton L. Montero , Jeffrey S. Bowers , Rui Ponte Costa , Casimir J. H. Ludwig , Gaurav Malhotra

Process model quality has been an area of considerable research efforts. In this context, the correctness-by-construction principle of change patterns offers a promising perspective. However, using change patterns for model creation imposes…

Software Engineering · Computer Science 2015-11-16 Barbara Weber , Jakob Pinggera , Victoria Torres , Manfred Reichert

Several genetic programming systems are created, each solving a different problem. In these systems, the median number of generations G needed to evolve a working program is measured. The behavior of G is observed as the difficulty of the…

Neural and Evolutionary Computing · Computer Science 2011-02-15 Mike Stimpson

The effort to understand network systems in increasing detail has resulted in a diversity of methods designed to extract their large-scale structure from data. Unfortunately, many of these methods yield diverging descriptions of the same…

Data Analysis, Statistics and Probability · Physics 2015-03-27 Tiago P. Peixoto