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Chemical reaction network theory is a powerful framework to describe and analyze chemical systems. While much about the concentration profile in an equilibrium state can be determined in terms of the graph structure, the overall reaction's…

Molecular Networks · Quantitative Biology 2024-02-29 Tomoharu Suda

Both non-neural and neural biological systems can learn. So rather than focusing on purely brain-like learning, efforts are underway to study learning in physical systems. Such efforts include equilibrium propagation (EP) and coupled…

Soft Condensed Matter · Physics 2022-06-24 Vidyesh Rao Anisetti , B. Scellier , J. M. Schwarz

We have introduced a mechanism for synchronizing chaotic systems by one way coupling with a variable delay that is reset at finite intervals. Here we extend this method to time delay systems and suggest a new cryptosystem based on this. We…

Chaotic Dynamics · Physics 2010-07-02 G. Ambika , R. E. Amritkar

In-memory computing (IMC) with single instruction multiple data (SIMD) setup enables memory to perform operations on the stored data in parallel to achieve high throughput and energy saving. To instruct a SIMD IMC hardware to compute a…

Emerging Technologies · Computer Science 2024-12-04 Xingyue Qian , Chenyang Lv , Zhezhi He , Weikang Qian

Time-delay systems are an important class of dynamical systems which provide a solid mathematical framework to deal with many application domains of interest ranging from biology, chemical, electrical, and mechanical engineering, to…

Dynamical Systems · Mathematics 2009-03-28 Giordano Pola , Pierdomenico Pepe , Maria D. Di Benedetto , Paulo Tabuada

The increased availability of data and computing resources has enabled researchers to successfully adopt machine learning (ML) techniques and make significant contributions in several engineering areas. ML and in particular deep learning…

Machine Learning · Computer Science 2025-02-10 Nunzio A. Letizia

While automated chemical tools excel at specific tasks, they have struggled to capture the strategic thinking that characterizes expert chemical reasoning. Here we demonstrate that large language models (LLMs) can serve as powerful tools…

Artificial Intelligence · Computer Science 2025-07-25 Andres M Bran , Theo A Neukomm , Daniel P Armstrong , Zlatko Jončev , Philippe Schwaller

Applications of machine learning in chemistry are often limited by the scarcity and expense of labeled data, restricting traditional supervised methods. In this work, we introduce a framework for molecular reasoning using general-purpose…

The synthesis of complex natural products remains one of the grand challenges of organic chemistry. We present DeepRetro, a major advancement in computational retrosynthesis that enables the discovery of viable synthetic routes for complex…

A practical deep neural network's (DNN) evaluation involves thousands of multiply-and-accumulate (MAC) operations. To extend DNN's superior inference capabilities to energy constrained devices, architectures and circuits that minimize…

Emerging Technologies · Computer Science 2020-08-04 Aditya Shukla

The ability to reason beyond established knowledge allows Organic Chemists to solve synthetic problems and to invent novel transformations. Here, we propose a model which mimics chemical reasoning and formalises reaction prediction as…

Artificial Intelligence · Computer Science 2017-12-27 Marwin H. S. Segler , Mark P. Waller

Coarse-grained modeling in molecular simulations serves not only to extend accessible time and length scales beyond atomistic limits, but also to reduce high-dimensional chemical data to low-dimensional representations that expose the…

Chemical Physics · Physics 2026-05-19 Michael N. Sakano , Alejandro Strachan

The dynamics of the delay logistic equation with complex parameters and arbitrary complex initial conditions is investigated. The analysis of the local stability of this difference equation has been carried out. We further exhibit several…

Dynamical Systems · Mathematics 2015-07-13 S. Sarif Hassan

Temperature is a fundamental regulator of chemical and biochemical kinetics, yet capturing nonlinear thermal effects directly from experimental data remains a major challenge due to limited throughput and model flexibility. Recent advances…

Quantitative Methods · Quantitative Biology 2025-12-23 Mamoru Saita , Yutaka Hori

The dynamic environment of laboratories and clinics, with streams of data arriving on a daily basis, requires regular updates of trained machine learning models for consistent performance. Continual learning is supposed to help train models…

Machine Learning · Computer Science 2025-08-12 Zahra Ebrahimi , Raheleh Salehi , Nassir Navab , Carsten Marr , Ario Sadafi

Computer-assisted synthesis planning aims to help chemists find better reaction pathways faster. Finding viable and short pathways from sugar molecules to value-added chemicals can be modeled as a retrosynthesis planning problem with a…

Other Computer Science · Computer Science 2019-11-19 Peihong Jiang , Hieu Doan , Sandeep Madireddy , Rajeev Surendran Assary , Prasanna Balaprakash

Self-driving laboratories (SDLs) consist of multiple stations that perform material synthesis and characterisation tasks. To minimize station downtime and maximize experimental throughput, it is practical to run experiments in asynchronous…

Machine Learning · Computer Science 2023-12-07 Hao Wen , Jakob Zeitler , Connor Rupnow

Recent advances in large language models (LLMs) have demonstrated transformative potential across diverse fields. While LLMs have been applied to molecular simplified molecular input line entry system (SMILES) in computer-aided synthesis…

Machine Learning · Computer Science 2026-01-07 Kenan Li , Yijian Zhang , Jin Wang , Haipeng Gan , Zeying Sun , Xiaoguang Lei , Hao Dong

Recent developments in computational chemistry facilitate the automated quantum chemical exploration of chemical reaction networks for the in-silico prediction of synthesis pathways, yield, and selectivity. However, the underlying quantum…

Chemical Physics · Physics 2025-10-22 Marco Eckhoff , Markus Reiher

Time delay is ubiquitous in many experimental and real-world situations. It is often unclear whether time delay plays a significant role in observed phenomena, and if it does, how long the time lag really is. This would be invaluable…

Data Analysis, Statistics and Probability · Physics 2025-12-10 Robin A. Kopp , Sabine H. L. Klapp , Deepak Gupta