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Composite endpoints are widely used as primary endpoints in clinical trials. Designing trials with time-to-event endpoints can be particularly challenging because the proportional hazard assumption usually does not hold when using a…

Methodology · Statistics 2022-11-07 Jordi Cortés Martinez , Marta Bofill Roig , Guadalupe Gómez Melis

Crossover designs are widely applied in medicine, agriculture, and other biological sciences, yet their analysis remains challenging due to longitudinal observations within each unit and the presence of carry-over effects. Despite their…

Computation · Statistics 2025-12-18 N. A. Cruz , O. O. Melo , C. A. Martinez , R. Alberich

This paper gives a review and synthesis of methods of evaluating dimensionality reduction techniques. Particular attention is paid to rank-order neighborhood evaluation metrics. A framework is created for exploring dimensionality reduction…

Machine Learning · Computer Science 2019-02-25 Stephen L. France , Ulas Akkucuk

Linear discriminant analysis (LDA) is a powerful tool in building classifiers with easy computation and interpretation. Recent advancements in science technology have led to the popularity of datasets with high dimensions, high orders and…

Computation · Statistics 2019-04-09 Yuqing Pan , Qing Mai , Xin Zhang

Large collections of high-dimensional data have become nearly ubiquitous across many academic fields and application domains, ranging from biology to the humanities. Since working directly with high-dimensional data poses challenges, the…

Ecological processes may exhibit memory to past disturbances affecting the resilience of ecosystems to future disturbance. Understanding the role of ecological memory in shaping ecosystem responses to disturbance under global change is a…

Computation · Statistics 2019-02-21 Malcolm S. Itter , Jarno Vanhatalo , Andrew O. Finley

We provide a pipeline for calculating, managing and visualising correlations and other pairwise association scores for numerical and categorical data. We present a uniform interface for calculating a plethora of pairwise scores and propose…

Computation · Statistics 2025-11-17 Amit Chinwan , Catherine B. Hurley

The dynamic mode decomposition (DMD) is a simple and powerful data-driven modeling technique that is capable of revealing coherent spatiotemporal patterns from data. The method's linear algebra-based formulation additionally allows for a…

Traditional applications of latent class models (LCMs) often focus on scenarios where a set of unobserved classes are well-defined and easily distinguishable. However, in numerous real-world applications, these classes are weakly separated…

Computation · Statistics 2023-09-21 Mengbing Li , Bolin Wu , Briana Stephenson , Zhenke Wu

High-dimensional time series analysis has become increasingly important in fields such as finance, economics, and biology. The two primary tasks for high-dimensional time series analysis are modeling and statistical inference, which aim to…

Computation · Statistics 2024-12-24 Jinyuan Chang , Jing He , Chen Lin , Qiwei Yao

Evolutionary multi-objective optimization (EMO) algorithms have been demonstrated to be effective in solving multi-criteria decision-making problems. In real-world applications, analysts often employ several algorithms concurrently and…

Neural and Evolutionary Computing · Computer Science 2024-08-09 Yansong Huang , Zherui Zhang , Ao Jiao , Yuxin Ma , Ran Cheng

The dynamics of many-body systems can often be captured in terms of only a few relevant variables. Mathematical and numerical approaches exist to identify these variables by exploiting a separation of time scales between slow relevant and…

With the rapid growth of modern technology, many large-scale biomedical studies have been/are being/will be conducted to collect massive datasets with large volumes of multi-modality imaging, genetic, neurocognitive, and clinical…

Methodology · Statistics 2018-03-07 Farouk S. Nathoo , Linglong Kong , Hongtu Zhu

Mindfulness and relaxation techniques for mental health are increasingly being explored in the human-computer interaction community. Physiological signals and their visualization have often been exploited together in a form of biofeedback…

Human-Computer Interaction · Computer Science 2023-10-24 Zihan Xu , Youngjun Cho

This paper presents a selective survey of recent developments in statistical inference and multiple testing for high-dimensional regression models, including linear and logistic regression. We examine the construction of confidence…

Methodology · Statistics 2023-01-26 T. Tony Cai , Zijian Guo , Yin Xia

With the rapid adoption of machine learning techniques for large-scale applications in science and engineering comes the convergence of two grand challenges in visualization. First, the utilization of black box models (e.g., deep neural…

Dimensionless learning is a data-driven framework for discovering dimensionless numbers and scaling laws from experimental measurements. This tutorial introduces the method, explaining how it transforms experimental data into compact…

Machine Learning · Computer Science 2025-12-19 Zhengtao Jake Gan , Xiaoyu Xie

Nonlinear programming targets nonlinear optimization with constraints, which is a generic yet complex methodology involving humans for problem modeling and algorithms for problem solving. We address the particularly hard challenge of…

Robotics · Computer Science 2021-01-29 David Hägele , Moataz Abdelaal , Ozgur S. Oguz , Marc Toussaint , Daniel Weiskopf

Since the turn of the millennium, computational modelling of biological systems has evolved remarkably and sees matured use spanning basic and clinical research. While the topic of the peri-millennial debate about the virtues and…

Quantitative Methods · Quantitative Biology 2025-08-05 Axel Loewe , Peter J. Hunter , Peter Kohl

The condvis package is for interactive visualization of sections in data space, showing fitted models on the section, and observed data near the section. The primary goal is the interpretation of complex models, and showing how the observed…

Other Statistics · Statistics 2016-10-04 Mark O'Connell , Catherine B. Hurley , Katarina Domijan