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We present an approach of using AI to model and simulate biology and life. Why is it important? Because at the core of medicine, pharmacy, public health, longevity, agriculture and food security, environmental protection, and clean energy,…

Artificial Intelligence · Computer Science 2024-12-11 Le Song , Eran Segal , Eric Xing

Biological systems and processes are networks of complex nonlinear regulatory interactions between nucleic acids, proteins, and metabolites. A natural way in which to represent these interaction networks is through the use of a graph. In…

Molecular Networks · Quantitative Biology 2023-01-04 Jacob Rast

To model biological systems using networks, it is desirable to allow more than two levels of expression for the nodes and to allow the introduction of parameters. Various modeling and simulation methods addressing these needs using Boolean…

Molecular Networks · Quantitative Biology 2014-04-23 Yi Ming Zou

Endowing brain anatomy, dynamics, and function with a network structure is becoming standard in neuroscience. In its simplest form, a network is a collection of units and relationships between them. The pattern of relations among the units…

Neurons and Cognition · Quantitative Biology 2025-07-22 David Papo , Javier M. Buldú

Agent-based modeling (ABM) is a well-established paradigm for simulating complex systems via interactions between constituent entities. Machine learning (ML) refers to approaches whereby statistical algorithms 'learn' from data on their…

Quantitative Methods · Quantitative Biology 2022-11-10 Nikita Sivakumar , Cameron Mura , Shayn M. Peirce

Pattern formation in biological tissues plays an important role in the development of living organisms. Since the classical work of Alan Turing, a pre-eminent way of modelling has been through reaction-diffusion mechanisms. More recently,…

Analysis of PDEs · Mathematics 2023-01-27 Alexey Kazarnikov , Robert Scheichl , Heikki Haario , Anna Marciniak-Czochra

A neural network system in an animal brain contains many modules and generates adaptive behavior by integrating the outputs from the modules. The mathematical modeling of such large systems to elucidate the mechanism of rapidly finding…

Adaptation and Self-Organizing Systems · Physics 2019-12-24 Kei-Ichi Ueda

Generating human-object interactions (HOIs) is critical with the tremendous advances of digital avatars. Existing datasets are typically limited to humans interacting with a single object while neglecting the ubiquitous manipulation of…

Computer Vision and Pattern Recognition · Computer Science 2024-09-12 Xintao Lv , Liang Xu , Yichao Yan , Xin Jin , Congsheng Xu , Shuwen Wu , Yifan Liu , Lincheng Li , Mengxiao Bi , Wenjun Zeng , Xiaokang Yang

Ant Colony Optimization (ACO) is a swarm intelligence methodology utilized for solving optimization problems through information transmission mediated by pheromones. As ants sequentially secrete pheromones that subsequently evaporate, the…

Neural and Evolutionary Computing · Computer Science 2024-10-31 Taiyo Shimizu , Shintaro Mori

We characterize different cell states, related to cancer and ageing phenotypes, by a measure of entropy of network ensembles, integrating gene expression values and protein interaction networks. The entropy measure estimates the parameter…

Molecular Networks · Quantitative Biology 2013-05-24 G. Menichetti , G. Bianconi , E. Giampieri , G. Castellani , D. Remondini

High-throughput experiments are shedding light on the topology of large regulatory networks and at the same time their functional states, namely the states of activation of the nodes (for example transcript or protein levels) in different…

Molecular Networks · Quantitative Biology 2009-02-13 M. Cosentino Lagomarsino , B. Bassetti , G. Castellani , D. Remondini

An agent-based model (ABM) is a computational model in which the local interactions of autonomous agents with each other and with their environment give rise to global properties within a given domain. As the detail and complexity of these…

Dynamical Systems · Mathematics 2022-12-01 Daniel A. Cruz , Jack Toppen , Eunbi Park , Melissa L. Kemp , Elena S. Dimitrova

This paper presents the online AnAmeter framework that helps characterize the different types of adaptations a system features by helping the evaluator fill in a simple form. The provided information is then processed to obtain a…

Human-Computer Interaction · Computer Science 2009-11-19 Franck Tarpin Bernard , Iza Marfisi-Schottman , Halima Habieb-Mammar

An increasing number of emerging applications, e.g., internet of things, vehicular communications, augmented reality, and the growing complexity due to the interoperability requirements of these systems, lead to the need to change the tools…

Multiagent Systems · Computer Science 2019-01-16 Merim Dzaferagic , M. Majid Butt , Maria Murphy , Nicholas Kaminski , Nicola Marchetti

Channel estimation is challenging in multi-antenna communication systems, because of the large number of parameters to estimate. One way of facilitating this task is to use a physical model describing the multiple paths constituting the…

Signal Processing · Electrical Eng. & Systems 2019-02-20 Luc Le Magoarou , Stéphane Paquelet

A great variety of systems in nature, society and technology -- from the web of sexual contacts to the Internet, from the nervous system to power grids -- can be modeled as graphs of vertices coupled by edges. The network structure,…

Adaptation and Self-Organizing Systems · Physics 2012-10-10 Petter Holme , Jari Saramäki

We propose a method of generating different scale-free networks, which has several input parameters in order to adjust the structure, so that they can serve as a basis for computer simulation of real-world phenomena. The topological…

Social and Information Networks · Computer Science 2014-01-30 Imre Varga , András Németh , Gergely Kocsis

The recent discovery of universal principles underlying many complex networks occurring across a wide range of length scales in the biological world has spurred physicists in trying to understand such features using techniques from…

Biological Physics · Physics 2015-05-13 Sitabhra Sinha

Accurately simulating physics is crucial across scientific domains, with applications spanning from robotics to materials science. While traditional mesh-based simulations are precise, they are often computationally expensive and require…

Machine Learning · Computer Science 2025-10-23 Philipp Dahlinger , Tai Hoang , Denis Blessing , Niklas Freymuth , Gerhard Neumann

Recent genomic and bioinformatic advances have motivated the development of numerous random network models purporting to describe graphs of biological, technological, and sociological origin. The success of a model has been evaluated by how…

Molecular Networks · Quantitative Biology 2007-05-23 Manuel Middendorf , Etay Ziv , Carter Adams , Jen Hom , Robin Koytcheff , Chaya Levovitz , Gregory Woods , Linda Chen , Chris Wiggins