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Typical brain networks consist of many peripheral regions and a few highly central ones, i.e. hubs, playing key functional roles in cerebral inter-regional interactions. Studies have shown that networks, obtained from the analysis of…

Neurons and Cognition · Quantitative Biology 2016-07-19 Manlio De Domenico , Shuntaro Sasai , Alex Arenas

Functional networks provide a topological description of activity patterns in the brain, as they stem from the propagation of neural activity on the underlying anatomical or structural network of synaptic connections. This latter is well…

Disordered Systems and Neural Networks · Physics 2021-02-11 Ali Safari , Paolo Moretti , Ibai Diez , Jesus M. Cortes , Miguel Ángel Muñoz

The relation between large-scale brain structure and function is an outstanding open problem in neuroscience. We approach this problem by studying the dynamical regime under which realistic spatio-temporal patterns of brain activity emerge…

Neurons and Cognition · Quantitative Biology 2014-05-27 Ariel Haimovici , Enzo Tagliazucchi , Pablo Balenzuela , Dante R. Chialvo

Recent work in cognitive neuroscience has focused on analyzing the brain as a network, rather than as a collection of independent regions. Prior studies taking this approach have found that individual differences in the degree of modularity…

Neurons and Cognition · Quantitative Biology 2017-11-28 Qiuhai Yue , Randi Martin , Simon Fischer-Baum , Aurora I. Ramos-Nuñez , Fengdan Ye , Michael W. Deem

Neural circuits comprise multiple interconnected regions, each with complex dynamics. The interplay between local and global activity is thought to underlie computational flexibility, yet the structure of multiregion neural activity and its…

Neurons and Cognition · Quantitative Biology 2025-01-09 David G. Clark , Manuel Beiran

Functional brain network has been widely studied to understand the relationship between brain organization and behavior. In this paper, we aim to explore the functional connectivity of brain network under a \emph{multi-step} cognitive task…

Neurons and Cognition · Quantitative Biology 2017-12-06 Shi-Min Cai , Wei Chen , Dong-Bai Liu , Ming Tang , Xun Chen

The brain is a complex system comprising a myriad of interacting elements, posing significant challenges in understanding its structure, function, and dynamics. Network science has emerged as a powerful tool for studying such intricate…

The relationship between brain structure and function has been probed using a variety of approaches, but how the underlying structural connectivity of the human brain drives behavior is far from understood. To investigate the effect of…

Neurons and Cognition · Quantitative Biology 2018-11-15 Kanika Bansal , John D. Medaglia , Danielle S. Bassett , Jean M. Vettel , Sarah F. Muldoon

Functional networks representing human brain dynamics have become a standard tool in neuroscience, providing an accessible way of depicting the computation performed by the brain in healthy and pathological conditions. Yet, these networks…

Neurons and Cognition · Quantitative Biology 2025-05-26 Sofia Gil-Rodrigo , Raúl López-Martín , Görsev Yener , Jan R. Wiersema , Bahar Güntekin , Massimiliano Zanin

Recent advances in network science, applied to \textit{in vivo} brain recordings, have paved the way for better understanding of the structure and function of the brain. However, despite its obvious usefulness in neuroscience, traditional…

Neurons and Cognition · Quantitative Biology 2025-02-03 Vesna Vuksanovic

Structure entails function and thus a structural description of the brain will help to understand its function and may provide insights into many properties of brain systems, from their robustness and recovery from damage, to their dynamics…

Neurons and Cognition · Quantitative Biology 2008-08-27 Marcus Kaiser , Robert Martin , Peter Andras , Malcolm P. Young

Intrinsic brain activity is characterized by highly structured co-activations between different regions, whose origin is still under debate. In this paper, we address the question whether it is possible to unveil how the underlying…

The functioning of an organ such as the brain emerges from interactions between its constituent parts. Further, this interaction is not immutable in time but rather unfolds in a succession of patterns, thereby allowing the brain to adapt to…

Neurons and Cognition · Quantitative Biology 2021-06-02 Emmanuelle Tognoli , Daniela Benites , J. A. Scott Kelso

Endowing brain anatomy, dynamics, and function with a network structure is becoming standard in neuroscience. In its simplest form, a network is a collection of units and relationships between them. The pattern of relations among the units…

Neurons and Cognition · Quantitative Biology 2025-07-22 David Papo , Javier M. Buldú

We present an approach to study functional segregation and integration in the living brain based on community structure decomposition determined by maximum modularity. We demonstrate this method with a network derived from functional…

Neurons and Cognition · Quantitative Biology 2007-05-23 Adam J. Schwarz , Alessandro Gozzi , Angelo Bifone

How an individual's unique brain connectivity determines that individual's cognition, behavior, and risk for pathology is a fundamental question in basic and clinical neuroscience. In seeking answers, many have turned to machine learning,…

Neurons and Cognition · Quantitative Biology 2023-12-08 Maxwell A. Bertolero , Dustin Moraczewski , Adam Thomas , Danielle S. Bassett

Modular structure is ubiquitous among real-world networks from related proteins to social groups. Here we analyze the modular organization of brain networks at a large-scale (voxel level) extracted from functional magnetic resonance imaging…

Data Analysis, Statistics and Probability · Physics 2009-04-16 M. Valencia , M. A. Pastor , MA. Fernandez-Seara , J. Artieda , J. Martinerie , M. Chavez

Activity in the human brain moves between diverse functional states to meet the demands of our dynamic environment, but fundamental principles guiding these transitions remain poorly understood. Here, we capitalize on recent advances in…

The human brain has been studied at multiple scales, from neurons, circuits, areas with well defined anatomical and functional boundaries, to large-scale functional networks which mediate coherent cognition. In a recent work, we addressed…

Biological Physics · Physics 2012-05-17 Lazaros K. Gallos , Mariano Sigman , Hernan A. Makse

The brain is a paradigmatic example of a complex system as its functionality emerges as a global property of local mesoscopic and microscopic interactions. Complex network theory allows to elicit the functional architecture of the brain in…

Neurons and Cognition · Quantitative Biology 2017-01-18 Rossana Mastrandrea , Andrea Gabrielli , Fabrizio Piras , Gianfranco Spalletta , Guido Caldarelli , Tommaso Gili