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Label-free detecting multiple analytes in a high-throughput fashion has been one of the long-sought goals in biosensing applications. Yet, for all-optical approaches, interfacing state-of-the-art label-free techniques with microfluidics…

Quantitative Methods · Quantitative Biology 2023-08-14 Alexia Stollmann , Jose Garcia-Guirado , Jae-Sang Hong , Hyungsoon Im , Hakho Lee , Jaime Ortega Arroyo , Romain Quidant

Devices based on photonic integrated circuits play a crucial role in the development of low-cost, high-performance, industry-scale manufacturable sensors. We report the design, fabrication, and application of a silicon nitride…

Interaction-free measurement (IFM) has been proposed as a means of high-resolution, low-damage imaging of radiation-sensitive samples, such as biomolecules and proteins. The basic setup for IFM is a Mach-Zehnder interferometer, and recent…

Instrumentation and Detectors · Physics 2019-06-12 Akshay Agarwal , Karl K. Berggren , Vivek Goyal

Despite being extremely old concepts, plasmonics and surface plasmon resonance-based biosensors have been increasingly popular in the recent two decades due to the growing interest in nanooptics and are now of relevant significance in…

Optics · Physics 2023-04-19 Giuseppina Simone

Immunoassay formats applicable for clinical or point-of-care diagnostics fall into two broad classes. One which uses labeled secondary antibodies for signal transduction and the other which does not require the use of any labels. Comparison…

Biological Physics · Physics 2015-05-06 Manoj M. Varma

While dimuonium $(\mu^+\mu^-)$ has not yet been observed, it is of utmost fundamental interest. By virtue of the larger mass, dimuonium has greater sensitivity to beyond the standard model effects than its cousins positronium or muonium,…

High Energy Physics - Experiment · Physics 2022-03-15 Patrick J. Fox , Sergo Jindariani , Vladimir Shiltsev

Nitrogen-vacancy (NV) based quantum sensors hold great potential for real-time single-cell sensing with far-reaching applications in fundamental biology and medical diagnostics. Although highly sensitive, the mapping of quantum measurements…

Sensors that are able to detect and track single unlabelled biomolecules are an important tool both to understand biomolecular dynamics and interactions at nanoscale, and for medical diagnostics operating at their ultimate detection limits.…

Optics · Physics 2016-11-15 N. P. Mauranyapin , L. S. Madsen , M. A. Taylor , M. Waleed , W. P. Bowen

Integrated chemical and biological sensors give advantages in cost, size and weight reduction and open new prospects for parallel monitoring and analysis. Biosensors based on nanoelectromechanical systems (NEMS) are the most attractive…

Optics · Physics 2019-04-29 Dmitry Yu. Fedyanin , Yury V. Stebunov

The use of relatively simple structures to achieve high performance refractive index sensors has always been urgently needed. In this work, we propose a lithography-free sensing platform based on metal-dielectric cavity, the sensitivity of…

Optics · Physics 2021-04-16 Ruoqin Yan , Tao Wang , Xiaoyun Jiang , Qingfang Zhong , Xing Huang

We examined the potential of antibody-functionalized single-walled carbon nanotube (SWNT) field-effect transistors (FETs) for use as a fast and accurate sensor for a Lyme disease antigen. Biosensors were fabricated on oxidized silicon…

Glucose biosensors play an important role in the diagnosis and continued monitoring of the disease, diabetes mellitus. This report proposes the development of a novel enzymatic electrochemical glucose biosensor based on TiO$_2$ nanotubes…

A micro-ring-resonator (MRR) optical biosensor based on the evanescent field sensing mechanism has been extensively studied due to its high sensitivity and compact device size. However, a suitable on-chip integrated spectrometer device has…

Optics · Physics 2022-07-19 Kyoung Min Yoo , May Hlaing , Sourabh Jain , James Fan , Yue An , Ray T. Chen

Magnetometers based on quantum mechanical processes enable high sensitivity and long-term stability without the need for re-calibration, but their integration into fieldable devices remains challenging. This paper presents a CMOS quantum…

Applied Physics · Physics 2020-07-23 Mohamed I. Ibrahim , Christopher Foy , Dirk R. Englund , Ruonan Han

The strong electric and magnetic resonances in dielectric subwavelength structures have enabled unique opportunities for efficient manipulation of light-matter interactions. Besides, the dramatic enhancement of nonlinear light-matter…

We describe a sensor for the measurement of thin dielectric layers capable of operation in a variety of environments. The sensor is obtained by microfabricating a capacitor with interleaved aluminum fingers, exposed to the dielectric to be…

Pulse timing is an important topic in nuclear instrumentation, with far-reaching applications from high energy physics to radiation imaging. While high-speed analog-to-digital converters become more and more developed and accessible, their…

Instrumentation and Detectors · Physics 2023-09-28 Pengcheng Ai , Le Xiao , Zhi Deng , Yi Wang , Xiangming Sun , Guangming Huang , Dong Wang , Yulei Li , Xinchi Ran

We theoretically demonstrate that a dipole layer on the electrode can modulate the transmission properties of nanoscale devices by influencing the contact properties, through first principles simulations on carbon nanotube based field…

Materials Science · Physics 2009-11-11 Li Yang , Jian Wu , Wenhui Duan , Bing-Lin Gu

The photo-kinetics of fluorescent molecules have enabled the circumvention of far-field optical diffraction-limit. Despite its enormous potential, the necessity to label the sample may adversely influence the delicate biology under…

Optical metasurface has brought a revolution in label-free molecular sensing, attracting extensive attention. Currently, such sensing approaches are being designed to respond to peak wavelengths with a higher Q factor in the visible and…

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