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Lateral Inhibition (LI) phenomena occur in a wide range of sensory modalities and are most famously described in the human visual system. In LI the activity of a stimulated neuron is itself excited and suppresses the activity of its local…

Emerging Technologies · Computer Science 2015-11-25 Jeff Dale Jones

We demonstrate how a genetic ring oscillator network with quorum sensing feedback can operate as a robust logic gate. Specifically we show how a range of logic functions, namely AND/NAND, OR/NOR and XOR/XNOR, can be realized by the system,…

Biological Physics · Physics 2014-04-14 Vidit Agrawal , Shivpal Singh Kang , Sudeshna Sinha

The giant single-celled slime mould Physarum polycephalum exhibits complex morphological adaptation and amoeboid movement as it forages for food and may be seen as a minimal example of complex robotic behaviour. Swarm computation has…

Multiagent Systems · Computer Science 2012-12-04 Jeff Jones , Andrew Adamatzky

This paper introduces Polyphorm, an interactive visualization and model fitting tool that provides a novel approach for investigating cosmological datasets. Through a fast computational simulation method inspired by the behavior of Physarum…

Instrumentation and Methods for Astrophysics · Physics 2020-09-08 Oskar Elek , Joseph N. Burchett , J. Xavier Prochaska , Angus G. Forbes

The manipulation of biological substrates is becoming more popular route towards generating novel computing devices. Physarum polycephalum is used as a model organism in biocomputing because it can create `wires' for use in hybrid circuits;…

Emerging Technologies · Computer Science 2015-12-08 Nina Gizzie , Richard Mayne , Shlomo Yitzchaik , Muhamad Ikbal , Andrew Adamatzky

Plasmodium of acellular slime mould Physarum polycephalum exhibits traits of wave-like behaviour. The plasmodium's behaviour can be finely tuned in laboratory experiments by using herbal tablets. A single tablet acts as a fixed attractor:…

Pattern Formation and Solitons · Physics 2012-12-13 Andrew Adamatzky

Living substrates are capable for nontrivial mappings of electrical signals due to the substrate nonlinear electrical characteristics. This property can be used to realise Boolean functions. Input logical values are represented by amplitude…

Emerging Technologies · Computer Science 2021-08-12 Nic Roberts , Andrew Adamatzky

Life evolved organisms to adapt dynamically to their environment and autonomously exhibit behaviours. While complex behaviours in organisms are typically associated with the capability of neurons to process information, the unicellular…

Biological Physics · Physics 2023-06-16 Mathieu Le Verge-Serandour , Karen Alim

The slime mould Physarum polycephalum displays adaptive transport dynamics and network formation that have inspired its use as a model of biological computation. We develop a Lagrangian formulation of Physarum's adaptive dynamics on…

Neurons and Cognition · Quantitative Biology 2025-11-12 Ricard Solé , Jordi Pla-Mauri

Optimization of fluid transport in the slime mold Physarum polycephalum has been the subject of several modeling efforts in recent literature. Existing models assume that the tube adaptation mechanism in P. polycephalum's tubular network is…

Tissues and Organs · Quantitative Biology 2019-07-01 Vincenzo Bonifaci

While computational capacity limits of the universe and carbon-based life have been estimated, a stricter bound for aneural organisms has not been established. Physarum polycephalum, a unicellular, multinucleated amoeba, is capable of…

Quantum Physics · Physics 2025-10-24 Suyash Bajpai , Aviva Lucas-DeMott , Nirosha J Murugan , Michael Levin , Philip Kurian

The slime mould Physarum polycephalum is known to construct proto- plasmic transport networks which approximate proximity graphs by forag- ing for nutrients during its plasmodial life cycle stage. In these networks, nodes are represented by…

Emerging Technologies · Computer Science 2015-11-19 Jeff Jones , Richard Mayne , Andrew Adamatzky

The slime mould Physarum polycephalum has emerged as a model for self-organisation and coordination of contractile activity at large spatial scales. This self-organisation largely results from cytoplasmic flows generated by propagating…

Soft Condensed Matter · Physics 2025-09-23 Raphael Saiseau , Valentin Busson , Marc Durand

Decision-making is the process of selecting an action among alternatives, allowing biological and artificial systems to navigate complex environments and optimize behavior. While neural systems rely on neuron-based sensory processing and…

Biological Physics · Physics 2025-06-17 Lisa Schick , Emily Eichenlaub , Fabian Drexel , Alexander Mayer , Siyu Chen , Marcus Roper , Karen Alim

Plasmonic logic circuits combine ultrafast operation with nanoscale integration, making them a strong candidate for next-generation optical computing. Realizing this potential, however, requires overcoming practical challenges such as bulky…

Optics · Physics 2025-10-07 Komal Gupta , Anand Hegde , Chen-Bin Huang

In this demo, we present a novel technique for approximating topologically optimal scaffoldings for 3D printed objects using a Monte Carlo algorithm based on the foraging behavior of the Physarum polycephalum slime mold. As a case study, we…

Graphics · Computer Science 2022-12-23 Drew Ehrlich , Milad Hakimshafaei , Oskar Elek

Surface-plasmon-polariton waves propagating at the interface between a metal and a dielectric, hold the key to future high-bandwidth, dense on-chip integrated logic circuits overcoming the diffraction limitation of photonics. While recent…

Magnetic skyrmions are promising candidates as elementary nanoscale bits in logic-in-memory devices, intrinsically merging high density memory and computing capabilities. Here we exploit the dynamics of skyrmions interacting with anisotropy…

Mesoscale and Nanoscale Physics · Physics 2022-09-07 Naveen Sisodia , Johan Pelloux-Prayer , Liliana D. Buda-Prejbeanu , Lorena Anghel , Gilles Gaudin , Olivier Boulle

We propose and numerically simulate novel reconfigurable logic gates employing spin metal-oxide-semiconductor field-effect transistors (spin MOSFETs). The output characteristics of the spin MOSFETs depend on the relative magnetization…

Materials Science · Physics 2007-05-23 Satoshi Sugahara , Tomohiro Matsuno , Masaaki Tanaka

Acellular slime mould Physarum polycephalum is a monstrously large single cell visible by an unaided eye. It shows sophisticated behavioural traits in foraging for nutrients and developing an optimal transport network of protoplasmic tubes…

Pattern Formation and Solitons · Physics 2013-05-17 Andrew Adamatzky