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In this paper we study a model of HCV with mitotic proliferation, a saturation infection rate and a discrete intracellular delay: the delay corresponds to the time between infection of a infected target hepatocytes and production of new HCV…

Dynamical Systems · Mathematics 2014-03-13 E. Avila-Vales , N. Chan-Chí , G. García-Almeida , C. Vargas-De-León

This paper analyses the dynamics of infectious disease with a concurrent spread of disease awareness. The model includes local awareness due to contacts with aware individuals, as well as global awareness due to reported cases of infection…

Populations and Evolution · Quantitative Biology 2017-04-21 G. O. Agaba , Y. N. Kyrychko , K. B. Blyuss

In this paper, we propose a mathematical model for HIV-1 infection with intracellular delay. The model examines a viral-therapy for controlling infections through recombining HIV-1 virus with a genetically modified virus. For this model,…

Dynamical Systems · Mathematics 2014-04-10 Yun Tian , Yu Bai , Pei Yu

In this paper, we develop a dynamic model of HIV infection that incorporates latent hosts, cytotoxic T lymphocyte (CTL) immunity, saturated incidence rates, and two transmission mechanisms: virus-to-cell and cell-to-cell transmission. The…

Dynamical Systems · Mathematics 2025-11-25 Songbo Hou , Xinxin Tian

In this research, we have derived a mathematical model for within human dynamics of COVID-19 infection using delay differential equations. The new model considers a 'latent period' and 'the time for immune response' as delay parameters,…

Populations and Evolution · Quantitative Biology 2025-01-14 Amar N. Chatterjee , Teklebirhan Abraha , Fahad Al Basir , Delfim F. M. Torres

In [Math. Comput. Sci. 12 (2018), no. 2, 111--127], a delayed model describing the dynamics of the Human Immunodeficiency Virus (HIV) with Cytotoxic T Lymphocytes (CTL) immune response is investigated by Allali, Harroudi and Torres. Here,…

Dynamical Systems · Mathematics 2022-10-03 Sandra Vaz , Delfim F. M. Torres

In this paper, a mathematical analysis of the global dynamics of a viral infection model in vivo is carried out. We study the dynamics of a hepatitis C virus (HCV) model, under therapy, that considers both extracellular and intracellular…

Populations and Evolution · Quantitative Biology 2020-11-13 Alexis Nangue , Alan D. Rendall , Brice Kammegne Tcheugam , Patrick Steve Kamdem Simo

We propose and investigate a delayed model that studies the relationship between HIV and the immune system during the natural course of infection and in the context of antiviral treatment regimes. Sufficient criteria for local asymptotic…

Optimization and Control · Mathematics 2018-03-19 Diana Rocha , Cristiana J. Silva , Delfim F. M. Torres

In this paper, we consider the impact of time delay by media on the control of the disease. We set up a class of SISM epidemic model with the time delay and the cumulative density of awareness caused by media. The sufficient condition of…

Populations and Evolution · Quantitative Biology 2016-09-14 Dongmei Li , Yue Wu , Panpan Wen , Weihua Liu

A delayed model describing the dynamics of HIV (Human Immunodeficiency Virus) with CTL (Cytotoxic T Lymphocytes) immune response is investigated. The model includes four nonlinear differential equations describing the evolution of…

Optimization and Control · Mathematics 2018-06-13 Karam Allali , Sanaa Harroudi , Delfim F. M. Torres

Understanding dynamics of an infectious disease helps in designing appropriate strategies for containing its spread in a population. Recent mathematical models are aimed at studying dynamics of some specific types of infectious diseases. In…

Dynamical Systems · Mathematics 2015-02-05 P. Raja Sekhara Rao , M. Naresh Kumar

The aims of this work is to analyse of the global stability of the extended model of hepatitis C virus(HCV) infection with cellular proliferation, spontaneous cure and hepatocyte homeostasis. We first give general information about…

Dynamical Systems · Mathematics 2019-05-08 Alexis Nangue , Cyprien Fokoue , Raoue Poumeni

This paper investigates the effects of vaccination on the dynamics of infectious disease, which is spreading in a population concurrently with awareness. The model considers contributions to the overall awareness from a global information…

Quantitative Methods · Quantitative Biology 2018-05-14 G. O. Agaba , Y. N. Kyrychko , K. B. Blyuss

We model intracellular regulatory dynamics with threshold-type state-dependent delay and investigate the effect of the state-dependent diffusion time. A general model which is an extension of the classic differential equation models with…

Dynamical Systems · Mathematics 2018-03-13 Qingwen Hu

We consider a mathematical model comprising of four coupled ordinary differential equations (ODEs) for studying the hepatitis C (HCV) viral dynamics. The model embodies the efficacies of a combination therapy of interferon and ribavirin. A…

Quantitative Methods · Quantitative Biology 2015-05-28 Gaurav Pachpute , Siddhartha P. Chakrabarty

Effects of immune delay on symmetric dynamics are investigated within a model of antigenic variation in malaria. Using isotypic decomposition of the phase space, stability problem is reduced to the analysis of a cubic transcendental…

Chaotic Dynamics · Physics 2012-09-21 K. B. Blyuss , Y. N. Kyrychko

The aim of this paper is to study the steady states of the mathematical models with delay kernels which describe pathogen-immune dynamics of many kinds of infectious diseases. In the study of mathematical models of infectious diseases it is…

Dynamical Systems · Mathematics 2007-05-23 M. Neamtu , L. Buliga , F. R. Horhat , D. Opris , A. T. Ceausu

In this paper, we investigate a novel 3-compartment model of HIV infection of CD4$^+$ T-cells with a mass action term by including two versions: one baseline ODE model and one delay-differential equation (DDE) model with a constant discrete…

Populations and Evolution · Quantitative Biology 2021-01-05 Hoang Anh Ngo , Hung Dang Nguyen , Mehmet Dik

In this work we introduce a differential equation model with time-delay that describes the three-stage dynamics and the two time scales observed in HIV infection. Assuming that the virus has high mutation and rapid reproduction rates that…

Biological Physics · Physics 2015-03-13 Flora S. Bacelar , Roberto F. S. Andrade , Rita M. Zorzenon dos Santos

In this paper, we investigate a reaction-diffusion-advection model with time delay effect. The stability/instability of the spatially nonhomogeneous positive steady state and the associated Hopf bifurcation are investigated when the given…

Dynamical Systems · Mathematics 2017-06-08 Shanshan Chen , Yuan Lou , Junjie Wei
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