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Artificial RNA molecules with novel functionality have many applications in synthetic biology, pharmacy and white biotechnology. The de novo design of such devices using computational methods and prediction tools is a resource-efficient…

Biomolecules · Quantitative Biology 2019-05-13 Stefan Hammer , Christian Günzel , Mario Mörl , Sven Findeiß

Nonlinear constrained optimization problems are encountered in many scientific fields. To utilize the huge calculation power of current computers, many mathematic models are also rebuilt as optimization problems. Most of them have…

Optimization and Control · Mathematics 2011-10-03 Wei Zhang , Xudong Shi , Liwen Wang

Early scheduling algorithms usually adjusted the clock cycle duration to the execution time of the slowest operation. This resulted in large slack times wasted in those cycles executing faster operations. To reduce the wasted times…

Hardware Architecture · Computer Science 2011-11-09 R. Ruiz-Sautua , M. C. Molina , J. M. Mendias , R. Hermida

Polymorphic circuits are a special kind of digital logic components, which possess multiple build-in functions. In different environments, a polymorphic circuit would perform different functions. Evolutionary Algorithms, Binary Decision…

Emerging Technologies · Computer Science 2017-09-12 Zhifang Li , Wenjian Luo , Lihua Yue , Xufa Wang

We typically construct optimal designs based on a single objective function. To better capture the breadth of an experiment's goals, we could instead construct a multiple objective optimal design based on multiple objective functions. While…

Methodology · Statistics 2023-03-09 Lucy L. Gao , Jane J. Ye , Shangzhi Zeng , Julie Zhou

Microalgae are an important source of precursors (e.g. lipids) for a variety of biosynthetic processes (e.g. biofuel production). Their co-culturing with other organisms providing essential substrates for growth may reduce cost and provide…

Optimization and Control · Mathematics 2025-09-04 Rand Asswad , Jean-Luc Gouzé , Eugenio Cinquemani

Living organisms rely on endogenous feedback mechanisms to maintain homeostasis in the presence of uncertainty and environmental fluctuations. An emerging challenge at the interface of control systems engineering and synthetic biology is…

Systems and Control · Electrical Eng. & Systems 2026-02-24 Mario di Bernardo

Engineering biology requires precise control of biomolecular circuits, and Cybergenetics is the field dedicated to achieving this goal. A significant challenge in developing controllers for cellular functions is designing systems that can…

Quantitative Methods · Quantitative Biology 2024-09-18 Hamza Faquir , Manuel Pájaro , Irene Otero-Muras

Industrial robots are designed as general-purpose hardware with limited ability to adapt to changing task requirements or environments. Modular robots, on the other hand, offer flexibility and can be easily customized to suit diverse needs.…

Robotics · Computer Science 2024-03-05 Jonathan Külz , Matthias Althoff

Bio-inspired optimization (including Evolutionary Computation and Swarm Intelligence) is a growing research topic with many competitive bio-inspired algorithms being proposed every year. In such an active area, preparing a successful…

Neural and Evolutionary Computing · Computer Science 2024-10-07 Antonio LaTorre , Daniel Molina , Eneko Osaba , Javier Del Ser , Francisco Herrera

Software architecture optimization aims to enhance non-functional attributes like performance and reliability while meeting functional requirements. Multi-objective optimization employs metaheuristic search techniques, such as genetic…

Scientific optimization problems are usually concerned with balancing multiple competing objectives, which come as preferences over both the outcomes of an experiment (e.g. maximize the reaction yield) and the corresponding input parameters…

Machine Learning · Computer Science 2025-01-28 Mohammad Haddadnia , Leonie Grashoff , Felix Strieth-Kalthoff

Several problems in signal processing are addressed by expert systems which take into account a set of priors on the sought signals and systems. For instance, blind source separation is often tackled by means of a mono-objective formulation…

Signal Processing · Electrical Eng. & Systems 2020-02-07 Guilherme Dean Pelegrina , Romis Attux , Leonardo Tomazeli Duarte

As global attention on renewable and clean energy grows, the research and implementation of microgrids become paramount. This paper delves into the methodology of exploring the relationship between the operational and environmental costs of…

Artificial Intelligence · Computer Science 2023-10-04 Hongyi Duan , Qingyang Li , Yuchen Li , Jianan Zhang , Yuming Xie

Development and optimization of biopharmaceutical production processes with cell cultures is cost- and time-consuming and often performed rather empirically. Efficient optimization of multiple-objectives like process time, viable cell…

Machine Learning · Computer Science 2022-05-09 Tanja Hernández Rodríguez , Anton Sekulic , Markus Lange-Hegermann , Björn Frahm

Real world problems always have different multiple solutions. For instance, optical engineers need to tune the recording parameters to get as many optimal solutions as possible for multiple trials in the varied-line-spacing holographic…

Neural and Evolutionary Computing · Computer Science 2015-08-04 Ka-Chun Wong

We consider the shape optimization of flow fields for electrochemical cells. Our goal is to improve the cell by modifying the shape of its flow field. To do so, we introduce simulation models of the flow field with and without the porous…

This paper addresses several critical stages of designing a walking robot, including optimal structural synthesis, introducing a novel 'rational' mechanical structure aimed at enhancing efficiency and simplifying control system, while…

Robotics · Computer Science 2025-05-05 Arman Ibrayeva , Batyrkhan Omarov

Electric machine design optimization is a computationally expensive multi-objective optimization problem. While the objectives require time-consuming finite element analysis, optimization constraints can often be based on mathematical…

Neural and Evolutionary Computing · Computer Science 2022-06-06 Bhuvan Khoshoo , Julian Blank , Thang Q. Pham , Kalyanmoy Deb , Shanelle N. Foster

Motivation: Many biochemical pathways are known, but the numerous parameters required to correctly explore the dynamics of the pathways are not known. For this reason, algorithms that can make inferences by looking at the topology of a…

Molecular Networks · Quantitative Biology 2009-07-23 Deepak Chandran , Herbert M. Sauro