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We study numerically how multiple deformable capsules squeeze into a constriction. This situation is largely encountered in microfluidic chips designed to manipulate living cells, which are soft entities. We use fully three-dimensional…

Soft Condensed Matter · Physics 2021-12-15 Clément Bielinski , Othmane Aouane , Jens Harting , Badr Kaoui

We study experimentally the motion and deformation of individual capsules transported by a constant volume-flux flow of low Reynolds number, through the T-junction of a channel with rectangular cross-section. We use millimetric…

Soft Condensed Matter · Physics 2020-02-19 E. Häner , M. Heil , A. Juel

Microcapsules with liquid cores encapsulated by thin membranes have many applications in science, medicine and industry. In this paper, we design a suspension of microcapsules which flow and deform like red blood cells (RBCs), as a valuable…

Soft Condensed Matter · Physics 2023-02-22 Qi Chen , Naval Singh , Kerstin Schirrmann , Qi Zhou , Igor Chernyavsky , Anne Juel

We theoretically predict and experimentally demonstrate that several different particle species can be separated from each other by means of a ratchet device, consisting of periodically arranged triangular (ratchet) shaped obstacles. We…

Statistical Mechanics · Physics 2012-03-26 Lukas Bogunovic , Ralf Eichhorn , Jan Regtmeier , Dario Anselmetti , Peter Reimann

We present a microfluidic device that enables trapping, analysis, and on-demand release of individual microparticles through membrane deformation driven by pneumatic actuation. Inspired by Pachinko-style architectures, the system features…

Applied Physics · Physics 2025-07-10 Alexandre Chargueraud , Lars Kool , Jacques Fattaccioli

Efficient sorting of target cells is crucial for advancing cellular research in biology and medical diagnostics. Inertial microfluidics, an emerging technology, offers a promising approach for label-free particle sorting with high…

Fluid Dynamics · Physics 2023-08-04 Sayan Karmakar , Md Safwan Mondal , Anish Pal , Sourav Sarkar

The mechanical deformability of single cells is an important indicator for various diseases such as cancer, blood diseases and inflammation. Lab-on-a-chip devices allow to separate such cells from healthy cells using hydrodynamic forces. We…

Fluid Dynamics · Physics 2019-02-08 Christian Schaaf , Holger Stark

We investigate the deformation of elastic microcapsules adsorbed at liquid-liquid interfaces. An initially spherical elastic capsule at a liquid-liquid interface undergoes circumferential stretching due to the liquid-liquid surface tension…

Soft Condensed Matter · Physics 2018-07-16 Jonas Hegemann , Horst-Holger Boltz , Jan Kierfeld

We investigate the inertial and non-inertial dynamics of three-dimensional elastic capsules flowing through a square channel presenting a sharp corner. Our study analyzes the trajectory, surface area, velocity and membrane stress of the…

Fluid Dynamics · Physics 2023-05-09 Damien P. Huet , Antoine Morente , Guodong Gai , Anthony Wachs

We study the motion of an elastic capsule through a microchannel characterized by a localized constriction. We consider a capsule with a stress-free spherical shape and impose its steady state configuration in an infinitely long straight…

Fluid Dynamics · Physics 2016-11-29 Cecilia Rorai , Antoine Touchard , Lailai Zhu , Luca Brandt

Sorting and separation of microparticles is a challenging problem of interdisciplinary nature. Existing technologies can differentiate microparticles by their bulk properties, such as size, density, electric polarizability, etc. The next…

Soft Condensed Matter · Physics 2018-09-03 Chenhui Peng , Taras Turiv , Yubing Guo , Qi-Huo Wei , Oleg D. Lavrentovich

Sorting elongated anisotropic particles, such as fibers, dispersed in suspensions poses significant challenges as they present two characteristic dimensions: length and diameter. Fibers in suspension usually align with the flow, leading to…

Soft Condensed Matter · Physics 2024-09-16 Justin Maddox , Alban Sauret

This work describes a new microfluidic device developed for rapid screening of solubility diagrams. In several parallel channels, hundreds of nanoliter-volume droplets of a given solution are first stored with a gradual variation in the…

Soft Condensed Matter · Physics 2007-05-23 P. Laval , N. Lisai , J. -B. Salmon , M. Joanicot

Microcapsules are a key class of microscale materials with applications in areas ranging from personal care to biomedicine, and with increasing potential to act as extracellular matrix (ECM) models of hollow organs or tissues. Such capsules…

The dynamics of a spherical elastic capsule, containing a Newtonian fluid bounded by an elastic membrane and immersed in another Newtonian fluid, in a uniform DC electric field is investigated. Discontinuity of electrical properties such as…

Soft Condensed Matter · Physics 2018-06-06 Sudip Das , Rochish M. Thaokar

We present a simple method for accessing the elastic properties of microscopic deformable particles. This method is based on measuring the pressure-induced deformation of soft particles as they are forced through a tapered glass…

Soft Condensed Matter · Physics 2012-09-04 Hans M. Wyss , Thomas Franke , Elisa Mele , David A. Weitz

Efficient particle sorting in microfluidic systems is vital for advancements in biomedical diagnostics and industrial applications. This study numerically investigates particle migration and passive sorting in symmetric serpentine…

Fluid Dynamics · Physics 2025-09-16 Sayan Karmakar , Anish Pal , Sourav Sarkar , Achintya Mukhopadhyay

We present a deformation-dependent propulsion phenomenon for soft particles such as cells in microchannels. It is based on a broken time reversal symmetry generated by a fast forward and slow backward motion of a fluid which does not…

Soft Condensed Matter · Physics 2022-02-22 Winfried Schmidt , Andre Förtsch , Matthias Laumann , Walter Zimmermann

The effects of cell size and deformability on the lateral migration and deformation of living cells flowing through a rectangular microchannel has been numerically investigated and compared with the inertial-microfluidics data on detection…

Fluid Dynamics · Physics 2013-06-21 Hongzhi Lan , Soojung Claire Hur , Dino Di Carlo , Damir B. Khismatullin

Dynamics of a deformable capsule in an oscillatory flow of a Newtonian fluid in a microchannel has been studied numerically. The effects of oscillation frequency, capsule deformability, and channel flow rate have been explored by simulating…

Soft Condensed Matter · Physics 2021-01-04 Ali Lafzi , Amir Hossein Raffiee , Sadegh Dabiri