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Multiple Instance Learning (MIL) is increasingly being used as a support tool within clinical settings for pathological diagnosis decisions, achieving high performance and removing the annotation burden. However, existing approaches for…

Computer Vision and Pattern Recognition · Computer Science 2025-08-01 Sungrae Hong , Kyungeun Kim , Juhyeon Kim , Sol Lee , Jisu Shin , Chanjae Song , Mun Yong Yi

A Bayesian approach to conduct network model selection is presented for a general class of network models referred to as the congruence class models (CCMs). CCMs form a broad class that includes as special cases several common network…

Applications · Statistics 2020-01-22 Ravi Goyal , Victor De Gruttola

When a predictive model is in production, it must be monitored in real-time to ensure that its performance does not suffer due to drift or abrupt changes to data. Ideally, this is done long before learning that the performance of the model…

A Bayesian multivariate model with a structured covariance matrix for multi-way nested data is proposed. This flexible modeling framework allows for positive and for negative associations among clustered observations, and generalizes the…

Methodology · Statistics 2024-08-27 Stef Baas , Richard J. Boucherie , Jean-Paul Fox

Time to an event of interest over a lifetime is a central measure of the clinical benefit of an intervention used in a health technology assessment (HTA). Within the same trial, multiple end-points may also be considered. For example,…

Applications · Statistics 2026-01-13 Nathan Green , Murat Kurt , Andriy Moshyk , James Larkin , Gianluca Baio

The convergence of IoT, Edge, Cloud, and HPC technologies creates a compute continuum that merges cloud scalability and flexibility with HPC's computational power and specialized optimizations. However, integrating cloud and HPC resources…

Distributed, Parallel, and Cluster Computing · Computer Science 2025-05-20 Aasish Kumar Sharma , Christian Boehme , Patrick Gelß , Ramin Yahyapour , Julian Kunkel

To facilitate healthcare delivery, language models (LMs) have significant potential for clinical prediction tasks using electronic health records (EHRs). However, in these high-stakes applications, unreliable decisions can result in high…

Computation and Language · Computer Science 2024-11-07 Zizhang Chen , Peizhao Li , Xiaomeng Dong , Pengyu Hong

Significant advancements have been made in recent years to optimize patient recruitment for clinical trials, however, improved methods for patient recruitment prediction are needed to support trial site selection and to estimate appropriate…

Machine Learning · Computer Science 2021-11-16 Jingshu Liu , Patricia J Allen , Luke Benz , Daniel Blickstein , Evon Okidi , Xiao Shi

Personalized medicine has become an important part of medicine, for instance predicting individual drug responses based on genomic information. However, many current statistical methods are not tailored to this task, because they overlook…

Applications · Statistics 2019-10-03 Shih-Ting Huang , Yannick Düren , Kristoffer H. Hellton , Johannes Lederer

Major advances have been made regarding the utilization of artificial intelligence in health care. In particular, deep learning approaches have been successfully applied for automated and assisted disease diagnosis and prognosis based on…

Methodology · Statistics 2020-03-24 Max Westphal , Antonia Zapf , Werner Brannath

The building thermodynamics model, which predicts real-time indoor temperature changes under potential HVAC (Heating, Ventilation, and Air Conditioning) control operations, is crucial for optimizing HVAC control in buildings. While…

Artificial Intelligence · Computer Science 2025-10-24 Yang Deng , Yaohui Liu , Rui Liang , Dafang Zhao , Donghua Xie , Ittetsu Taniguchi , Dan Wang

Clinical decision-making is a feedback system where risk estimates influence treatment, which in turn changes disease trajectories, and both shape clinicians' measurement practices. Static prediction often fails clinically: models trained…

Artificial Intelligence · Computer Science 2026-05-19 Pujun Feng , Xiaoyu Guo , Seyed Ehsan Saffari , Min Hun Lee , Siew-Kei Lam , Erik Cambria , Xibin Sun , Yangtao Zhou , Tong Yang , Xiaoyu Zhang , Tao Tan , Yue Sun , Bin Cui

Historical data about disease outcomes can be integrated into the analysis of clinical trials in many ways. We build on existing literature that uses prognostic scores from a predictive model to increase the efficiency of treatment effect…

Methodology · Statistics 2020-12-25 David Walsh , Alejandro Schuler , Diana Hall , Jon Walsh , Charles Fisher

A key challenge in sequential decision making is optimizing systems safely under partial information. While much of the literature has focused on the cases of either partially known states or partially known dynamics, it is further…

Optimization and Control · Mathematics 2023-04-21 Qinyang He , Yonatan Mintz

The focus of this paper is on quantifying the capacity of covariates in devising efficient treatment rules when data from a randomized trial are available. Conventional one-variable-at-a-time subgroup analysis based on statistical…

Applications · Statistics 2020-02-04 Mohsen Sadatsafavi , Mohammad Mansournia , Paul Gustafson

Early detection of patients vulnerable to infections acquired in the hospital environment is a challenge in current health systems given the impact that such infections have on patient mortality and healthcare costs. This work is focused on…

Shared mental models are critical to team success; however, in practice, team members may have misaligned models due to a variety of factors. In safety-critical domains (e.g., aviation, healthcare), lack of shared mental models can lead to…

Artificial Intelligence · Computer Science 2022-05-11 Sangwon Seo , Lauren R. Kennedy-Metz , Marco A. Zenati , Julie A. Shah , Roger D. Dias , Vaibhav V. Unhelkar

Prediction models need reliable predictive performance as they inform clinical decisions, aiding in diagnosis, prognosis, and treatment planning. The predictive performance of these models is typically assessed through discrimination and…

Methodology · Statistics 2025-04-25 Wouter A. C. van Amsterdam

Typically, machine learning models are trained and evaluated without making any distinction between users (e.g, using traditional hold-out and cross-validation). However, this produces inaccurate performance metrics estimates in multi-user…

Machine Learning · Computer Science 2023-12-11 Enrique Garcia-Ceja , Luciano Garcia-Banuelos , Nicolas Jourdan

The growing demand for key healthcare resources such as clinical expertise and facilities has motivated the emergence of artificial intelligence (AI) based decision support systems. We address the problem of predicting clinical workups for…

Machine Learning · Computer Science 2020-07-24 Morteza Noshad , Ivana Jankovic , Jonathan H. Chen
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