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Biological cells sense external chemical stimuli in their environment using cell-surface receptors. To increase the sensitivity of sensing, receptors often cluster, most noticeably in bacterial chemotaxis, a paradigm for signaling and…

Biological Physics · Physics 2015-05-27 Gerardo Aquino , Diana Clausznitzer , Sylvain Tollis , Robert G. Endres

Many membrane-bound molecules in cells form small clusters. It has been hypothesized that these clusters convert an analog extracellular signal into a digital intracellular signal and that this conversion increases signaling fidelity.…

Molecular Networks · Quantitative Biology 2019-08-28 Edward Roob , Nicola Trendel , Pieter Rein ten Wolde , Andrew Mugler

Order parameter fluctuations (the largest cluster size distribution) are studied within a three-dimensional bond percolation model on small lattices. Cumulant ratios measuring the fluctuations exhibit distinct features near the percolation…

Nuclear Theory · Physics 2007-05-23 Janusz Brzychczyk

Cellular adaptation to environmental changes relies on the dynamic remodeling of subcellular structures. Among these, sarcomere structures are fundamental to the organization and function of the cytoskeletal architecture. In muscle-type…

Cell Behavior · Quantitative Biology 2024-12-17 Yuika Ueda , Shinji Deguchi

Earthquake network is known to be of the small-world type. The values of the network characteristics, however, depend not only on the cell size (i.e., the scale of coarse graining needed for constructing the network) but also on the size of…

Geophysics · Physics 2015-05-19 Sumiyoshi Abe , Denisse Pasten , Norikazu Suzuki

In this letter, we focus on the size effect of granular column collapses, which are potentially connected to the dynamics of complex geophysical flows, even if the link between microscopic structures of granular assemblies and their…

Soft Condensed Matter · Physics 2022-01-21 Teng Man , Herbert E. Huppert , Ling Li , Sergio Andres Galindo-Torres

Models with a nonequilibrium wetting transition display a transition also in finite systems. This is different from nonequilibrium phase transitions into an absorbing state, where the stationary state is the absorbing one for any value of…

Statistical Mechanics · Physics 2011-03-01 Andre Cardoso Barato

The macroscopic behavior of the solution of a coupled system of partial differential equations arising in the modeling of reaction-diffusion processes in periodic porous media is analyzed. Our mathematical model can be used for studying…

Analysis of PDEs · Mathematics 2019-06-19 G. Cardone , C. Perugia , C. Timofte

Using computer simulations, we validate a simple free energy model that can be analytically solved to predict the equilibrium size of self-limiting clusters of particles in the fluid state governed by a combination of short-range attractive…

Soft Condensed Matter · Physics 2016-08-25 Jonathan A. Bollinger , Thomas M. Truskett

Organelle patterning and its heritability remain central mysteries in cell biology, highlighting the fundamental tension between genetic inheritance and self-assembly. Here, we explore the nonequilibrium assembly and emdedded size control…

Soft Condensed Matter · Physics 2026-05-22 Amit Kumar , Madan Rao

This paper focuses on size effects in periodic mechanical metamaterials driven by reversible pattern transformations due to local elastic buckling instabilities in their microstructure. Two distinct loading cases are studied: compression…

Soft Condensed Matter · Physics 2018-09-11 M. M. Ameen , O. Rokoš , R. H. J. Peerlings , M. G. D. Geers

The formation of polarized signaling domains on cell membranes is a fundamental example of biological pattern formation. While such patterns resemble structures from equilibrium phase separation, they are intrinsically non-equilibrium,…

Biological Physics · Physics 2025-12-10 Damiano Andreghetti , Alfredo Braunstein , Luca Dall'Asta , Andrea Gamba

Pattern formation often occurs in confined systems, yet how boundaries shape patterning dynamics is unclear. We develop techniques to analyze confinement effects in nonlocal advection-diffusion equations, which generically capture the…

Pattern Formation and Solitons · Physics 2025-09-11 Jan Rombouts , Michael L Zhao , Alexander Aulehla , Anna Erzberger

The proper functioning of multicellular organisms requires the robust establishment of precise proportions between distinct cell-types. This developmental differentiation process typically involves intracellular regulatory and stochastic…

Cell Behavior · Quantitative Biology 2016-06-22 Benjamin Pfeuty , Kunihiko Kaneko

Large-scale cellular transformations are triggered by subtle physical and structural changes in individual biomacromolecular and membrane components. A prototypical example of such an event is the orchestrated fusion of membranes within an…

Soft Condensed Matter · Physics 2023-10-02 Ashesh Ghosh , Andrew J. Spkaowitz

We explore semi-dilute and concentrated oligomers and polymers in a broad range of polymerization indices N ranging from 1 to a 100 and in a range of monomer number densities $\phi$ from 0.1 to 0.8 via molecular dynamics simulations and…

Soft Condensed Matter · Physics 2020-12-01 Ashod Khederlarian , Carmen Almasri , Leonid Klushin

Cells control their size to cope with noise during growth and division. Eukaryotic cells exhibiting "sizer" control (targeting a specific size before dividing) may rely on molecular concentration thresholds, but simple implementations of…

Biological Physics · Physics 2026-05-08 Motasem ElGamel , Lucas Ribaudo , Andrew Mugler

Mechanical stresses stemming from environmental factors are a key determinant of cellular behavior and physiology. Yet, the role of self-induced biomechanical stresses in growing bacterial colonies has remained largely unexplored. Here, we…

Soft Condensed Matter · Physics 2023-11-27 René Wittmann , G. H. Philipp Nguyen , Hartmut Löwen , Fabian J. Schwarzendahl , Anupam Sengupta

Cells maintain a stable size as they grow and divide. Inspired by the available experimental data, most proposed models for size homeostasis assume size control mechanisms that act on a timescale of one generation. Such mechanisms lead to…

Biological Physics · Physics 2023-05-25 Motasem ElGamel , Harsh Vashistha , Hanna Salman , Andrew Mugler

Cells actively regulate their size during the cell cycle to maintain volume homeostasis across generations. While various mathematical models of cell size regulation have been proposed to explain how this is achieved, relating these models…

Quantitative Methods · Quantitative Biology 2025-04-11 Kaan Öcal , Michael P. H. Stumpf
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