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Accurate prediction of clinical outcomes using Electronic Health Records (EHRs) is critical for early intervention, efficient resource allocation, and improved patient care. EHRs contain multimodal data, including both structured data and…

Machine Learning · Computer Science 2025-08-29 Rituparna Datta , Jiaming Cui , Zihan Guan , Vishal G. Reddy , Joshua C. Eby , Gregory Madden , Rupesh Silwal , Anil Vullikanti

Background: The stochastic behavior of patient arrival at an emergency department (ED) complicates the management of an ED. More than 50% of hospitals ED capacity tends to operate beyond its normal capacity and eventually fails to deliver…

Computers and Society · Computer Science 2019-01-10 Avishek Choudhury

We propose a Bayesian model selection approach that allows medical practitioners to select among predictor variables while taking their respective costs into account. Medical procedures almost always incur costs in time and/or money. These…

Methodology · Statistics 2024-05-07 Erica M. Porter , Christopher T. Franck , Stephen Adams

An endeavor central to precision medicine is predictive biomarker discovery; they define patient subpopulations which stand to benefit most, or least, from a given treatment. The identification of these biomarkers is often the byproduct of…

Methodology · Statistics 2022-08-01 Philippe Boileau , Nina Ting Qi , Mark J. van der Laan , Sandrine Dudoit , Ning Leng

Appropriate dosing of radiation is crucial to patient safety in radiotherapy. Current quality assurance depends heavily on a peer-review process, where the physicians' peer review on each patient's treatment plan, including dose and…

Machine Learning · Computer Science 2021-12-01 Qiongge Li , Jean Wright , Russell Hales , Ranh Voong , Todd McNutt

A retention strategy based on an enlightened lapse model is a powerful profitabilitylever for a life insurer. Some machine learning models are excellent at predicting lapse,but from the insurer's perspective, predicting which policyholder…

Statistics Theory · Mathematics 2023-07-14 Mathias Valla , Xavier Milhaud , Anani Ayodélé Olympio

The behavior of users in relatively predictable, both in terms of the data they request and the wireless channels they observe. In this paper, we consider the statistics of such predictable patterns of the demand and channel jointly across…

Information Theory · Computer Science 2018-06-14 L. Srikar Muppirisetty , John Tadrous , Atilla Eryilmaz , Henk Wymeersch

Clinical trials are critical for drug development but often suffer from expensive and inefficient patient recruitment. In recent years, machine learning models have been proposed for speeding up patient recruitment via automatically…

Machine Learning · Computer Science 2023-07-20 Brandon Theodorou , Cao Xiao , Jimeng Sun

Many in-hospital mortality risk prediction scores dichotomize predictive variables to simplify the score calculation. However, hard thresholding in these additive stepwise scores of the form "add x points if variable v is above/below…

Machine Learning · Statistics 2015-04-30 Natalia M. Arzeno , Karla A. Lawson , Sarah V. Duzinski , Haris Vikalo

The call for patient-focused drug development is loud and clear, as expressed in the 21st Century Cures Act and in recent guidelines and initiatives of regulatory agencies. Among the factors contributing to modernized drug development and…

The quality of service in healthcare is constantly challenged by outlier events such as pandemics (i.e. Covid-19) and natural disasters (such as hurricanes and earthquakes). In most cases, such events lead to critical uncertainties in…

Artificial Intelligence · Computer Science 2021-11-16 Chih-Hao Huang , Feras A. Batarseh , Adel Boueiz , Ajay Kulkarni , Po-Hsuan Su , Jahan Aman

Risk adjustment has become an increasingly important tool in healthcare. It has been extensively applied to payment adjustment for health plans to reflect the expected cost of providing coverage for members. Risk adjustment models are…

Machine Learning · Computer Science 2019-07-16 Qiu-Yue Zhong , Andrew H. Fairless , Jasmine M. McCammon , Farbod Rahmanian

Emergency triage decisions are made under severe information constraints, yet most data-driven deterioration models are evaluated using signals unavailable during initial assessment. We present a leakage-aware benchmarking framework for…

Computers and Society · Computer Science 2026-03-31 KMA Solaiman , Joshua Sebastian , Karma Tobden

Stroke is known as a major global health problem, and for stroke survivors it is key to monitor the recovery levels. However, traditional stroke rehabilitation assessment methods (such as the popular clinical assessment) can be subjective…

Signal Processing · Electrical Eng. & Systems 2022-12-27 Xi Chen , Yu Guan , Jian Qing Shi , Xiu-Li Du , Janet Eyre

The intensive care unit (ICU) manages critically ill patients, many of whom face a high risk of mortality. Early and accurate prediction of in-hospital mortality within the first 24 hours of ICU admission is crucial for timely clinical…

The distribution of health care payments to insurance plans has substantial consequences for social policy. Risk adjustment formulas predict spending in health insurance markets in order to provide fair benefits and health care coverage for…

Applications · Statistics 2021-02-25 Anna Zink , Sherri Rose

Medical events of interest, such as mortality, often happen at a low rate in electronic medical records, as most admitted patients survive. Training models with this imbalance rate (class density discrepancy) may lead to suboptimal…

Machine Learning · Computer Science 2022-08-02 Zepeng Huo , Xiaoning Qian , Shuai Huang , Zhangyang Wang , Bobak J. Mortazavi

Hospitals struggle to predict critical outcomes. Traditional early warning systems, like NEWS and MEWS, rely on static variables and fixed thresholds, limiting their adaptability, accuracy, and personalization. We previously developed the…

As data shift or new data become available, updating clinical machine learning models may be necessary to maintain or improve performance over time. However, updating a model can introduce compatibility issues when the behavior of the…

Machine Learning · Statistics 2023-08-11 Erkin Ötleş , Brian T. Denton , Jenna Wiens

Nearly 300,000 older adults experience a hip fracture every year, the majority of which occur following a fall. Unfortunately, recovery after fall-related trauma such as hip fracture is poor, where older adults diagnosed with Alzheimer's…

Methodology · Statistics 2024-02-05 Biyi Shen , Haoyu Ren , Michelle Shardell , Jason Falvey , Chixiang Chen