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Stem cell heterogeneity is essential for the homeostasis in tissue development. This paper established a general formulation for understanding the dynamics of stem cell regeneration with cell heterogeneity and random transitions of…

Populations and Evolution · Quantitative Biology 2024-07-12 Jinzhi Lei

We investigate the interplay between two fundamental mechanisms of microbial population dynamics and evolution called dormancy and horizontal gene transfer. The corresponding traits come in many guises and are ubiquitous in microbial…

Probability · Mathematics 2021-05-26 Jochen Blath , András Tóbiás

Since its introduction in 1952, Turing's (pre-)pattern theory ("the chemical basis of morphogenesis") has been widely applied to a number of areas in developmental biology. The related pattern formation models normally comprise a system of…

Cell Behavior · Quantitative Biology 2020-10-28 Fiona R Macfarlane , Mark AJ Chaplain , Tommaso Lorenzi

This survey focuses on the most important aspects of the mathematical theory of population genetic models of selection and migration between discrete niches. Such models are most appropriate if the dispersal distance is short compared to…

Populations and Evolution · Quantitative Biology 2019-12-13 Reinhard Bürger

We consider a reaction-diffusion model for a population structured in phenotype. We assume that the population lives in a heterogeneous periodic environment, so that a given phenotypic trait may be more or less fit according to the spatial…

Analysis of PDEs · Mathematics 2025-03-07 Nathanaël Boutillon , Luca Rossi

T1 transitions, which are localised cell rearrangements, play an important role in the fluidization of epithelial monolayers. Using a multi-phase field model and an active elastic solid model, we show that although each cell undergoes T1…

Biological Physics · Physics 2025-02-11 Harish P. Jain , Richard D. J. G. Ho , Luiza Angheluta

It is known that the competitive exclusion principle holds for a large kind of models involving several species competing for a single resource in an homogeneous environment. Various works indicate that the coexistence is possible in an…

Analysis of PDEs · Mathematics 2014-07-22 François Castella , Sten Madec , Yvan Lagadeuc

The presence of one or more species at some spatial locations but not others is a central matter in ecology. This phenomenon is related to ecological pattern formation. Nonlocal interactions can be considered as one of the mechanisms…

Populations and Evolution · Quantitative Biology 2017-12-29 Ozgur Aydogmus

We consider a mutation-selection model of a population structured by the spatial variables and a trait variable which is the diffusion rate. Competition for resource is local in spatial variables, but nonlocal in the trait variable. We…

Analysis of PDEs · Mathematics 2020-04-20 King-Yeung Lam , Yuan Lou

The spread of infectious disease and the evolution of antigenically distinct strains are often modeled separately, despite strong feedbacks mediated by host immune memory and heterogeneous contacts. To tackle this challenging problem, we…

Populations and Evolution · Quantitative Biology 2026-04-01 Davide Zanchetta , Vittoria Bettio , Sandro Azaele , Manlio De Domenico

Existing studies comparing individual-based models of growing cell populations and their continuum counterparts have mainly focused on homogeneous populations, in which all cells have the same phenotypic characteristics. However,…

Populations and Evolution · Quantitative Biology 2022-06-06 Fiona R Macfarlane , Xinran Ruan , Tommaso Lorenzi

The spread of an infectious disease can be promoted by previous infections with other pathogens. This cooperative effect can give rise to violent outbreaks, reflecting the presence of an abrupt epidemic transition. As for other diffusive…

Physics and Society · Physics 2019-02-06 Peng-Bi Cui , Francesca Colaiori , Claudio Castellano

This paper studies spatial patterns formed by proximate population migration driven by real wage gradients and other idiosyncratic factors. The model consists of a tractable core-periphery model incorporating a quasi-linear log utility…

Theoretical Economics · Economics 2025-07-23 Kensuke Ohtake

Population survival depends on a large set of factors that includes environment structure. Due to landscape heterogeneity, species can occupy particular regions that provide the ideal scenario for development, working as a refuge from…

Statistical Mechanics · Physics 2020-11-04 M. A. F. dos Santos , V. Dornelas , E. H. Colombo , C. Anteneodo

Mechanisms leading to speciation are a major focus in evolutionary biology. In this paper, we present and study a stochastic model of population where individuals, with type a or A, are equivalent from ecological, demographical and spatial…

Populations and Evolution · Quantitative Biology 2017-04-20 Camille Coron , Manon Costa , Hélène Leman , Charline Smadi

A tumor can be thought of as an ecosystem, which critically means that we cannot just consider it as a collection of mutated cells but more as a complex system of many interacting cellular and microenvironmental elements. At its simplest, a…

Populations and Evolution · Quantitative Biology 2013-05-03 Jill Gallaher , Alexander R. A. Anderson

We present a stochastic approach to modeling the dynamics of coexistence of prey and predator populations. It is assumed that the space of coexistence is explicitly subdivided in a grid of cells. Each cell can be occupied by only one…

Populations and Evolution · Quantitative Biology 2015-06-26 Kelly C. de Carvalho , Tania Tome

How should dispersal strategies be chosen to increase the likelihood of survival of a species? We obtain the answer for the spatially extended versions of three well-known models of two competing species with unequal diffusivities. Though…

Populations and Evolution · Quantitative Biology 2020-07-08 Tapas Singha , Prasad Perlekar , Mustansir Barma

Diffusion plays an important role in a wide variety of phenomena, from bacterial quorum sensing to the dynamics of traffic flow. While it generally tends to level out gradients and inhomogeneities, diffusion has nonetheless been shown to…

Pattern Formation and Solitons · Physics 2024-07-03 Alexandre Champagne-Ruel , Sascha Zakaib-Bernier , Paul Charbonneau

Bacteria can form a great variety of spatially heterogeneous cell density patterns, ranging from simple concentric rings to dynamical spiral waves appearing in growing colonies. These pattern formation phenomena are important as they…

Populations and Evolution · Quantitative Biology 2025-01-17 John S. Chuang , Riccardo Rao , Stanislas Leibler
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