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In this paper, we derive a new chemotaxis model with degenerate diffusion and density-dependent chemotactic sensitivity, and we provide a more realistic description of cell migration process for its early and late stages. Different from the…

Analysis of PDEs · Mathematics 2023-07-19 Tianyuan Xu , Shanming Ji , Chunhua Jin , Ming Mei , Jingxue Yin

Human mobility and activity patterns mediate contagion on many levels, including the spatial spread of infectious diseases, diffusion of rumors, and emergence of consensus. These patterns however are often dominated by specific locations…

Physics and Society · Physics 2011-07-05 Duygu Balcan , Alessandro Vespignani

Dispersal of species to find a more favorable habitat is important in population dynamics. Dispersal rates evolve in response to the relative success of different dispersal strategies. In a simplified deterministic treatment (J. Dockery, V.…

Populations and Evolution · Quantitative Biology 2009-07-28 David A. Kessler , Leonard M. Sander

Numerous experimental studies have demonstrated that the microenvironment is a key regulator influencing the proliferative and migrative potentials of species. Spatial and temporal disturbances lead to adverse and hazardous…

Populations and Evolution · Quantitative Biology 2015-10-07 Venkata. S. K. Manem , Kamran Kaveh , Mohammad Kohandel , Siv Sivaloganathan

In this paper, we study pattern formations in an aggregation and diffusion cell migration model with Dirichlet boundary condition. The formal continuum limit of the model is a nonlinear parabolic equation with a diffusivity which can become…

Analysis of PDEs · Mathematics 2020-11-30 Lianzhang Bao

Understanding under what conditions interacting populations, whether they be plants, animals, or viral particles, coexist is a question of theoretical and practical importance in population biology. Both biotic interactions and…

Populations and Evolution · Quantitative Biology 2011-04-26 Sebastian J. Schreiber , Michel Benaïm , Kolawolé A. S. Atchadé

Highly-diverse ecosystems exhibit a broad distribution of population sizes and species turnover, where species at high and low abundances are exchanged over time. We show that these two features generically emerge in the fluctuating phase…

Populations and Evolution · Quantitative Biology 2024-01-09 Thibaut Arnoulx de Pirey , Guy Bunin

The outcome of competition among species is influenced by the spatial distribution of species and effects such as demographic stochasticity, immigration fluxes, and the existence of preferred habitats. We introduce an individual-based model…

Populations and Evolution · Quantitative Biology 2010-07-19 Simone Pigolotti , Massimo Cencini

A fundamental feature of collective cell migration is phenotypic heterogeneity which, for example, influences tumour progression and relapse. While current mathematical models often consider discrete phenotypic structuring of the cell…

Cell Behavior · Quantitative Biology 2024-06-12 Rebecca M. Crossley , Kevin J. Painter , Tommaso Lorenzi , Philip K. Maini , Ruth E. Baker

In subdivided populations, migration acts together with selection and genetic drift and determines their evolution. Building up on a recently proposed method, which hinges on the emergence of a time scale separation between local and global…

Populations and Evolution · Quantitative Biology 2015-03-24 Pierangelo Lombardo , Andrea Gambassi , Luca Dall'Asta

Viruses like influenza have long coevolved with host immune systems, gradually shaping the evolutionary trajectory of these pathogens. Host immune systems develop immunity against circulating strains, which in turn avoid extinction by…

We present a simple mathematical model that captures the evolutionary capabilities of a prebiotic compartment or protocell. In the model the protocell contains an autocatalytic set whose chemical dynamics is coupled to the growth-division…

Populations and Evolution · Quantitative Biology 2023-10-31 Angad Yuvraj Singh , Sanjay Jain

This study presents physical observations and insights into particle migration characteristics throughout the suffusion process. Using a purpose-built coaxial permeameter cell, suffusion experiments were conducted on idealised internally…

We present an atomistic study of heterogeneous nucleation in Ni employing transition path sampling, which reveals a template precursor-mediated mechanism of crystallization. Most notably, we find that the ability of tiny templates to modify…

Materials Science · Physics 2022-05-04 Grisell Díaz Leines , Jutta Rogal

We consider a partial differential equation model for the growth of heterogeneous cell populations subdivided into multiple distinct discrete phenotypes. In this model, cells preferentially move towards regions where they feel less…

Analysis of PDEs · Mathematics 2025-04-04 José A. Carrillo , Tommaso Lorenzi , Fiona R. Macfarlane

The presence of phenomena analogous to phase transition in Statistical Mechanics, has been suggested in the evolution of a polygenic trait under stabilizing selection, mutation and genetic drift. By using numerical simulations of a model…

Populations and Evolution · Quantitative Biology 2017-02-13 Annalisa Fierro , Sergio Cocozza , Antonella Monticelli , Giovanni Scala , Gennaro Miele

We propose a minimal off-lattice model of living organisms where just a very few dynamical rules of growth are assumed. The stable coexistence of many clusters is detected when we replace the global restriction rule by a locally applied…

Physics and Society · Physics 2021-08-19 B. F. de Oliveira , M. V. de Moraes , D. Bazeia , A. Szolnoki

Maintaining tissue homeostasis requires appropriate regulation of stem cell differentiation. The Waddington landscape posits that gene circuits in a cell form a potential landscape of different cell types, wherein cells follow attractors of…

Quantitative Methods · Quantitative Biology 2023-09-15 Rongsheng Huang , Qiaojun Situ , Jinzhi Lei

The evolution of complex cellular life involved two major transitions: the encapsulation of self-replicating genetic entities into cellular units and the aggregation of individual genes into a collectively replicating genome. In this paper,…

Populations and Evolution · Quantitative Biology 2021-09-21 Daniel B. Cooney , Fernando W. Rossine , Dylan H. Morris , Simon A. Levin

We extend a model for the morphology and dynamics of a crawling eukaryotic cell to describe cells on micropatterned substrates. This model couples cell morphology, adhesion, and cytoskeletal flow in response to active stresses induced by…

Cell Behavior · Quantitative Biology 2015-06-17 Brian A. Camley , Yanxiang Zhao , Bo Li , Herbert Levine , Wouter-Jan Rappel