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Epithelial monolayers are some of the best-studied models for collective cell migration due to their abundance in multicellular systems and their tractability. Experimentally, the collective migration of epithelial monolayers can be…

Quantitative Methods · Quantitative Biology 2024-02-15 Simon F. Martina-Perez , Isaac B. Breinyn , Daniel J. Cohen , Ruth E. Baker

Aberrantly regulated cell motility is a hallmark of cancer cells. A hybrid agent-based model has been developed to investigate the synergistic and antagonistic cell motility-impacting effects of three microenvironment variables…

Cell Behavior · Quantitative Biology 2008-06-26 L. Leon Chen , Le Zhang , Jeongah Yoon , Thomas S. Deisboeck

Cells swimming in viscous fluids create flow fields which influence the transport of relevant nutrients, and therefore their feeding rate. We propose a modeling approach to the problem of optimal feeding at zero Reynolds number. We consider…

Fluid Dynamics · Physics 2011-10-19 Sébastien Michelin , Eric Lauga

We perform Brownian dynamics simulations in two dimensions to study the collective behavior of circle swimmers, which are driven by both, an (effective) translational and rotational self-propulsion, and interact via steric repulsion. We…

Soft Condensed Matter · Physics 2021-06-09 Guo-Jun Liao , Sabine H. L. Klapp

Living systems often exhibit internal driving: active, molecular processes drive nonequilibrium phenomena such as metabolism or migration. Active gels constitute a fascinating class of internally driven matter, where molecular motors exert…

Biological Physics · Physics 2015-06-15 Jose Alvarado , Michael Sheinman , Abhinav Sharma , Fred C. MacKintosh , Gijsje H. Koenderink

We construct a homogeneous, nonlinear elastic constitutive law, that models aspects of the mechanical behavior of inhomogeneous fibrin networks. Fibers in such networks buckle when in compression. We model this as a loss of stiffness in…

Biological Physics · Physics 2015-12-18 Phoebus Rosakis , Jacob Notbohm , Guruswami Ravichandran

Cells move differently on substrates with different elasticities. In particular, the persistence time of their motion is higher on stiffer substrates. We show that this behavior will result in a net transport of cells directed up a…

Biological Physics · Physics 2017-03-09 Elizaveta A. Novikova , Matthew Raab , Dennis E. Discher , Cornelis Storm

We study the force production dynamics of undulating elastic plates as a model for fish-like inertial swimmers. Using a beam model coupled with Lighthill's large-amplitude elongated-body theory, we explore different localised actuations at…

Fluid Dynamics · Physics 2017-12-25 Miguel Piñeirua , Benjamin Thiria , Ramiro Godoy-Diana

A simple and popular constitutive model used to describe the compressional strength of a consolidating strongly cohesive particulate gel is tested further with new experimental data. Strong cohesive particulate gels have variously been…

We present an experimental study of the statistical properties of millimeter-size spheres floating on the surface of a turbulent flow. The flow is generated in a layer of liquid metal by an electromagnetic forcing. By using two magnet…

Fluid Dynamics · Physics 2016-07-04 Pablo Gutiérrez , Sébastien Aumaître

Intracellular cargos which are transported by molecular motors move stochastically along cytoskeleton filaments. In particular for bidirectionally transported cargos it is an open question whether the characteristics of their motion can…

Biological Physics · Physics 2017-09-20 Sarah Klein , Cecile Appert-Rolland , Ludger Santen

The dynamics of cellular pattern formation is crucial for understanding embryonic development and tissue morphogenesis. Recent studies have shown that human dermal fibroblasts cultured on liquid crystal elastomers can exhibit an increase in…

Biological Physics · Physics 2023-08-25 Mengyang Gu , Xinyi Fang , Yimin Luo

We present an individual-based model for two interacting populations diffusing on lattices in which a strong natural selection develops spontaneously. The models combine traditional local predator-prey dynamics with random walks.…

Populations and Evolution · Quantitative Biology 2007-05-23 Monica F. B. Moreira , Marcio P. Dantas , A. T. Costa

The locomotion of flexible membrane-like organisms on top of curved surfaces appears in different contexts and scales. Still, such dynamics have not yet been quantitatively modeled and no realization of such motion in manmade systems has…

Soft Condensed Matter · Physics 2024-02-27 Omri Y. Cohen , Yael Klein , Eran Sharon

The eukaryotic cell's cytoskeleton is a prototypical example of an active material: objects embedded within it are driven by molecular motors acting on the cytoskeleton, leading to anomalous diffusive behavior. Experiments tracking the…

Soft Condensed Matter · Physics 2021-11-12 Daniel W. Swartz , Brian A. Camley

We study a model for the motion of a tracer particle inside an active gel, exposing the properties of the van Hove distribution of the particle displacements. Active events of a typical force magnitude give rise to non-Gaussian…

Soft Condensed Matter · Physics 2019-03-06 Nitzan Razin , Raphael Voituriez , Nir S. Gov

Experimental studies of cell motility in culture have shown that under adequate conditions these living organisms possess the ability to organize themselves into complex structures. Such structures may exhibit a synergy that greatly…

Statistical Mechanics · Physics 2021-10-27 G. Nakamura , M. Badoual , E. Fabiani , C. Deroulers

The packing of elastic sheets is investigated in a quasi two-dimensional experimental setup: a sheet is pulled through a rigid hole acting as a container, so that its configuration is mostly prescribed by the cross-section of the sheet in…

Classical Physics · Physics 2009-11-13 Stephanie Deboeuf , Mokhtar Adda-Bedia , Arezki Boudaoud

We consider the diffusion-advection problem in two simple cellular flow models (often invoked as examples for subdiffusive tracer's motion) and concentrate on the intermediate time range, in which the tracer's motion indeed may show…

Fluid Dynamics · Physics 2016-09-28 Patrick Pöschke , Igor M. Sokolov , Alexander A. Nepomnyashchy , Michael A. Zaks

Eukaryotic flagella are active structures with a complex architecture of microtubules, motor proteins and elastic links. They are capable of whiplike motions driven by motors sliding along filaments that are themselves constrained at an…

Soft Condensed Matter · Physics 2012-11-22 Raghunath Chelakkot , Arvind Gopinath , L. Mahadevan , Michael F. Hagan
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