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We investigate conductance and conductance fluctuations of two transmembrane proteins, bacteriorhodopsin and proteorhodopsin, belonging to the family of protein light receptors. These proteins are widely diffused in aqueous environments,…

Soft Condensed Matter · Physics 2013-05-27 E. Alfinito , J. Pousset , L. Reggiani

When moving from native to light activated bacteriorhodopsin, modification of charge transport consisting of an increase of conductance is correlated to the protein conformational change. A theoretical model based on a map of the protein…

Quantitative Methods · Quantitative Biology 2011-02-17 Eleonora Alfinito , Lino Reggiani

Recently, a growing interest has been addressed to the electrical properties of bacteriorhodopsin (bR), a protein belonging to the transmembrane protein family. To take into account the structure-dependent nature of the current, in a…

Soft Condensed Matter · Physics 2015-03-06 E. Alfinito , L. Reggiani

The increasing interest in photoactivated proteins as natural replacement of standard inorganic materials in photocells drives to the compared analysis of bacteriorhodopsin and proteorhodopsin, two widely diffused proteins belonging to the…

Biological Physics · Physics 2015-06-16 E Alfinito , J Pousset , L Reggiani , K Lee

Current voltage (I-V) characteristics in proteins can be sensitive to conformational change induced by an external stimulus (photon, odour, etc.). This sensitivity can be used in medical and industrial applications besides shedding new…

Soft Condensed Matter · Physics 2015-05-28 Eleonora Alfinito , Jean-Francois Millithaler , Lino Reggiani

We report on charge transport and current fluctuations in a single bacteriorhodpsin protein in a wide range of applied voltages covering direct and injection tunnelling regimes. The satisfactory agreement between theory and available…

Mesoscale and Nanoscale Physics · Physics 2011-02-17 J. -F. Millithaler , E. Alfinito , L. Reggiani

The electrical properties of a set of seven-helix transmembrane proteins, whose space arrangement (3D structure) is known, are investigated by using regular arrays of the amino acids. These structures, specifically cubes, have topological…

Soft Condensed Matter · Physics 2016-06-02 Eleonora Alfinito , Lino Reggiani

One of the main trend in to date research and development is the miniaturization of electronic devices. In this perspective, integrated nanodevices based on proteins or biomolecules are attracting a major interest. In fact, it has been…

Quantitative Methods · Quantitative Biology 2015-06-26 E. Alfinito , C. Pennetta , L. Reggiani

We report on electrical properties of the two sensing proteins: bacteriorhodopsin and rat olfactory receptor OR-I7. As relevant transport parameters we consider the small-signal impedance spectrum and the static current-voltage…

Mesoscale and Nanoscale Physics · Physics 2015-05-27 E. Alfinito , L. Reggiani

The interaction of light with photosynthetic proteins is an extremely efficient process and has been thoroughly investigated. However, exploring light-matter interactions in hybrid nano-solid-photosynthetic proteins is a relatively new and…

Biological Physics · Physics 2024-11-20 Itai Carmeli , Chanoch Carmeli

How molecules convert light energy to perform a specific transformation is a fundamental question in photophysics. Ultrafast spectroscopy reveals the kinetics associated with electronic energy flow, but little is known about how absorbed…

The mini-review gives special attention to holistic approach and mechanisms of processes. The physical and chemical frames and background for visual perception and signalling are discussed. Perception of photons by retinal rod cells is…

Other Quantitative Biology · Quantitative Biology 2013-07-01 Vadim Volkov

New science and new technology need new materials and new concepts. In this respect, biological matter can play a primary role because it is a material with interesting and innovative features that have found several applications in…

Applied Physics · Physics 2022-01-26 E. Alfinito , R. Cataldo , L. Reggiani

Photoactive proteins absorb light and undergo structural changes that enable them to perform essential biological functions. These proteins are critical for understanding light-induced biological processes, making them important in…

Chemical Physics · Physics 2025-03-28 Sylwia Czach , Jakub Rydzewski , Wiesław Nowak

We present a palette of brightly fluorescent genetically encoded voltage indicators (GEVIs) with excitation and emission peaks spanning the visible spectrum, sensitivities from 6 - 10% Delta F/F per 100 mV, and half-maximal response times…

Biological systems transduce signals from their surroundings in numerous ways. This paper introduces a communication system using the light-gated ion channel Channelrhodopsin-2 (ChR2), which causes an ion current to flow in response to…

Information Theory · Computer Science 2024-11-11 Taha Sajjad , Andrew W. Eckford

The need of new diagnostic methods satisfying, as an early detection, a low invasive procedure and a cost-efficient value, is orienting the technological research toward the use of bio-integrated devices, in particular bio-sensors. The set…

Biomolecules · Quantitative Biology 2015-06-18 E. Alfinito , L. Reggiani

Nucleic acids and proteins are not only biologically important polymers: They have recently been recognized as novel functional materials surpassing in many aspects the conventional ones. Although Herculean efforts have been undertaken to…

Soft Condensed Matter · Physics 2010-06-17 Waleed Shinwari , Jamal Deen , Evgeni Starikov , Gianaurelio Cuniberti

It is shown that a small subset of modes which are likely to be involved in protein functional motions of large amplitude can be determined by retaining the most robust normal modes obtained using different protein models. This result…

Biomolecules · Quantitative Biology 2007-05-23 Samuel Nicolay , Yves-Henri Sanejouand

Biosensors are frequently used nowadays for the sake of their attractive capabilities. Because of their high accuracy and precision, they are more and more used in the medical sector. Natural receptors are mostly used, but their use have…

Cell Behavior · Quantitative Biology 2021-02-17 Juul Goossens , Gilles Oudebrouckx , Seppe Bormans , Thijs Vandenryt , Ronald Thoelen
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