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We consider the problem of constructing a code capable of correcting a single long tandem duplication error of variable length. As the main contribution of this paper, we present a $q$-ary efficiently encodable code of length $n+1$ and…

Information Theory · Computer Science 2023-04-26 Daniil Goshkoder , Nikita Polyanskii , Ilya Vorobyev

DNA as a data storage medium has several advantages, including far greater data density compared to electronic media. We propose that schemes for data storage in the DNA of living organisms may benefit from studying the reconstruction…

Information Theory · Computer Science 2019-09-10 Yonatan Yehezkeally , Moshe Schwartz

DNA-based storage is an emerging storage technology that provides high information density and long duration. Due to the physical constraints in the reading and writing processes, error correction in DNA storage poses several interesting…

Information Theory · Computer Science 2023-10-04 Jin Sima , Netanel Raviv , Moshe Schwartz , Jehoshua Bruck

Several processes in the cell, such as gene regulation, start when key proteins recognise and bind to short DNA sequences. However, as these sequences can be hundreds of million times shorter than the genome, they are hard to find by simple…

Subcellular Processes · Quantitative Biology 2021-01-27 Markus Nyberg , Tobias Ambjörnsson , Per Stenberg , and Ludvig Lizana

In this work, we investigate a challenging problem, which has been considered to be an important criterion in designing codewords for DNA computing purposes, namely secondary structure avoidance in single-stranded DNA molecules. In short,…

Information Theory · Computer Science 2023-02-28 Tuan Thanh Nguyen , Kui Cai , Han Mao Kiah , Duc Tu Dao , Kees A. Schouhamer Immink

The mathematical concept of q-deformations, in particular the one of qnumbers, is used to study the genetic code(s). After considering two kinds of q-numbers, for comparison, a phenomenological classification scheme of the genetic code…

Other Quantitative Biology · Quantitative Biology 2016-07-26 Tidjani Negadi

Error-correcting codes over sets, with applications to DNA storage, are studied. The DNA-storage channel receives a set of sequences, and produces a corrupted version of the set, including sequence loss, symbol substitution, symbol…

Information Theory · Computer Science 2021-07-12 Hengjia Wei , Moshe Schwartz

Function-correcting codes are a coding framework designed to minimize redundancy while ensuring that specific functions or computations of encoded data can be reliably recovered, even in the presence of errors. The choice of metric is…

Information Theory · Computer Science 2026-02-18 Gyanendra K. Verma , Abhay Kumar Singh

We consider a new family of codes, termed asymmetric Lee distance codes, that arise in the design and implementation of DNA-based storage systems and systems with parallel string transmission protocols. The codewords are defined over a…

Information Theory · Computer Science 2016-12-16 Ryan Gabrys , Han Mao Kiah , Olgica Milenkovic

Similarity query is the family of queries based on some similarity metrics. Unlike the traditional database queries which are mostly based on value equality, similarity queries aim to find targets "similar enough to" the given data objects,…

Databases · Computer Science 2022-04-19 Yifan Wang

We consider the problem of storing and retrieving information from synthetic DNA media. The mathematical basis of the problem is the construction and design of sequences that may be discriminated based on their collection of substrings…

Information Theory · Computer Science 2015-02-03 Han Mao Kiah , Gregory J. Puleo , Olgica Milenkovic

DNA sequence encoding is fundamental to gene function prediction, protein synthesis, and diverse downstream biological tasks. Despite the substantial progress achieved by large-scale DNA sequence pretraining, existing studies have…

Machine Learning · Computer Science 2026-04-21 Zhijiang Tang , Jiaxin Qi , Yan Cui , Jinli Ou , Yuhua Zheng , Jianqiang Huang

DNA hybridization is a fundamental reaction with wide-ranging applications in biotechnology. The nearest-neighbor (NN) model provides the most reliable description of the energetics of duplex formation. Most DNA thermodynamics studies have…

Biomolecules · Quantitative Biology 2024-04-30 Paolo Rissone , Marc Rico-Pasto , Steve Smith , Felix Ritort

Herein it is shown that in order to study the statistical properties of DNA sequences in bacterial chromosomes it suffices to consider only one half of the chromosome because they are similar to its corresponding complementary sequence in…

Genomics · Quantitative Biology 2009-11-10 Marco V. Jose , Tzipe Govezensky , Juan R. Bobadilla

We study superdense coding with uniformly accelerated particle in single mode approximation and beyond single mode approximation. We use four different functions, the capacity of superdense coding, negativity, discord and the probability of…

This paper introduces a new solution to DNA storage that integrates all three steps of retrieval, namely clustering, reconstruction, and error correction. DNA-correcting codes are presented as a unique solution to the problem of ensuring…

Information Theory · Computer Science 2024-07-02 Avital Boruchovsky , Daniella Bar-Lev , Eitan Yaakobi

In coding theory, handling errors that occur when symbols are inserted or deleted from a transmitted message is a long-standing challenge. Optimising redundancy for insertion and deletion channels remains a key open problem with significant…

Information Theory · Computer Science 2026-02-02 Anamika Singh , Abhay Kumar Singh

We study the maximum length of $q$-ary codes as a function of alphabet size, code size, and Singleton defect. For an $(n, M, d)_q$ code with dimension $\kappa = \log_q M \ge 2$ and Singleton defect $s = n - \lceil\kappa\rceil + 1 - d$, we…

Combinatorics · Mathematics 2026-04-07 Tim Alderson

We study codes that can correct backtracking errors during nanopore sequencing. In this channel, a sequence of length $n$ over an alphabet of size $q$ is being read by a sliding window of length $\ell$, where from each window we obtain only…

Information Theory · Computer Science 2024-08-16 Wenjun Yu , Zuo Ye , Moshe Schwartz

A family of distance-optimal LRC codes from certain subcodes of $q$-ary Reed-Solomon codes, proposed by I.~Tamo and A.~Barg in 2014, assumes that the code length $n$ is a multiple of $r+1.$ By shortening codes from this family, we show that…

Information Theory · Computer Science 2018-02-02 Oleg Kolosov , Alexander Barg , Itzhak Tamo , Gala Yadgar