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We present a new scalable, lightweight algorithm to incrementally construct the BWT and FM-index of large string sets such as those produced by Next Generation Sequencing. The algorithm is designed for massive parallelism and can…

Data Structures and Algorithms · Computer Science 2014-10-03 Jacopo Pantaleoni

In order to avoid the reference bias introduced by mapping reads to a reference genome, bioinformaticians are investigating reference-free methods for analyzing sequenced genomes. With large projects sequencing thousands of individuals,…

Data Structures and Algorithms · Computer Science 2016-01-15 Jouni Sirén

We present a new semi-external algorithm that builds the Burrows--Wheeler transform variant of Bauer et al. (a.k.a., BCR BWT) in linear expected time. Our method uses compression techniques to reduce computational costs when the input is…

Data Structures and Algorithms · Computer Science 2023-08-15 Diego Díaz-Domínguez , Gonzalo Navarro

Motivation The Burrows-Wheeler transform (BWT) is the foundation of many algorithms for compression and indexing of text data, but the cost of computing the BWT of very large string collections has prevented these techniques from being…

Data Structures and Algorithms · Computer Science 2015-03-20 Anthony J. Cox , Markus J. Bauer , Tobias Jakobi , Giovanna Rosone

In recent years, the focus of bioinformatics research has moved from individual sequences to collections of sequences. Given the fundamental role of the Burrows-Wheeler Transform (BWT) in string processing, a number of dedicated tools have…

Data Structures and Algorithms · Computer Science 2025-05-28 Davide Cenzato , Zsuzsanna Lipták

The Burrows-Wheeler transform (BWT) is integral to the FM-index, which is used extensively in text compression, indexing, pattern search, and bioinformatic problems as de novo assembly and read alignment. Thus, efficient construction of the…

Data Structures and Algorithms · Computer Science 2025-02-04 Enno Adler , Stefan Böttcher , Rita Hartel , Cederic Alexander Steininger

The Burrows-Wheeler Transform (BWT) serves as the basis for many important sequence indexes. On very large datasets (e.g. genomic databases), classical BWT construction algorithms are often infeasible because they usually need to have the…

Data Structures and Algorithms · Computer Science 2025-09-24 Jannik Olbrich

Popular sequence alignment tools such as BWA convert a reference genome to an indexing data structure based on the Burrows-Wheeler Transform (BWT), from which matches to individual query sequences can be rapidly determined. However the…

Genomics · Quantitative Biology 2013-04-23 Anthony J. Cox , Tobias Jakobi , Giovanna Rosone , Ole B. Schulz-Trieglaff

Indexing of very large collections of strings such as those produced by the widespread sequencing technologies, heavily relies on multi-string generalizations of the Burrows-Wheeler Transform (BWT), and for this problem various in-memory…

Data Structures and Algorithms · Computer Science 2016-07-29 Paola Bonizzoni , Gianluca Della Vedova , Serena Nicosia , Marco Previtali , Raffaella Rizzi

Constructing the Burrows-Wheeler transform (BWT) for long strings poses significant challenges regarding construction time and memory usage. We use a prefix of the suffix array to partition a long string into shorter substrings, thereby…

Data Structures and Algorithms · Computer Science 2025-05-15 Enno Adler , Stefan Böttcher , Rita Hartel

Motivation: Burrows-Wheeler Transform (BWT) is a common component in full-text indices. Initially developed for data compression, it is particularly powerful for encoding redundant sequences such as pangenome data. However, BWT construction…

Genomics · Quantitative Biology 2025-09-10 Heng Li

Due to the exponential growth of genomic data, constructing dedicated data structures has become the principal bottleneck in common bioinformatics applications. In particular, the Burrows-Wheeler Transform (BWT) is the basis of some of the…

Data Structures and Algorithms · Computer Science 2023-05-15 Francesco Masillo

We present an algorithm for building the extended BWT (eBWT) of a string collection from its grammar-compressed representation. Our technique exploits the string repetitions captured by the grammar to boost the computation of the eBWT.…

Genomics · Quantitative Biology 2021-02-10 Diego Diaz-Dominguez annd Gonzalo Navarro

It is known that the exact form of the Burrows-Wheeler-Transform (BWT) of a string collection depends, in most implementations, on the input order of the strings in the collection. Reordering strings of an input collection affects the…

Data Structures and Algorithms · Computer Science 2022-12-05 Davide Cenzato , Veronica Guerrini , Zsuzsanna Lipták , Giovanna Rosone

The Burrows-Wheeler Transform (BWT) is an efficient invertible text transformation algorithm with the properties of tending to group identical characters together in a run, and enabling search of the text. This transformation has extensive…

Human-Computer Interaction · Computer Science 2024-02-28 Lily Major , Dave Davies , Amanda Clare , Jacqueline W. Daykin , Benjamin Mora , Christine Zarges

Mantaci et al. [TCS 2007] defined the eBWT to extend the definition of the BWT to a collection of strings, however, since this introduction, it has been used more generally to describe any BWT of a collection of strings and the fundamental…

Data Structures and Algorithms · Computer Science 2021-06-22 Christina Boucher , Davide Cenzato , Zsuzsanna Lipták , Massimiliano Rossi , Marinella Sciortino

The Burrows-Wheeler Transform (BWT) is a string transformation technique widely used in areas such as bioinformatics and file compression. Many applications combine a run-length encoding (RLE) with the BWT in a way which preserves the…

Discrete Mathematics · Computer Science 2025-09-18 Lily Major , Amanda Clare , Jacqueline W. Daykin , Benjamin Mora , Christine Zarges

Burrows-Wheeler transform (BWT) is an invertible text transformation that, given a text $T$ of length $n$, permutes its symbols according to the lexicographic order of suffixes of $T$. BWT is one of the most heavily studied algorithms in…

Data Structures and Algorithms · Computer Science 2020-12-09 Dominik Kempa , Tomasz Kociumaka

The Burrows-Wheeler transform (BWT) is a well studied text transformation widely used in data compression and text indexing. The BWT of two strings can also provide similarity measures between them, based on the observation that the more…

Data Structures and Algorithms · Computer Science 2020-09-10 Felipe A. Louza , Guilherme P. Telles , Simon Gog , Liang Zhao

Indexing very large collections of strings, such as those produced by the widespread next generation sequencing technologies, heavily relies on multistring generalization of the Burrows-Wheeler Transform (BWT): large requirements of…

Data Structures and Algorithms · Computer Science 2020-12-07 Paola Bonizzoni , Gianluca Della Vedova , Yuri Pirola , Marco Previtali , Raffaella Rizzi
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