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Systems biology uses large networks of biochemical reactions to model the functioning of biological cells from the molecular to the cellular scale. The dynamics of dissipative reaction networks with many well separated time scales can be…

Molecular Networks · Quantitative Biology 2013-05-28 Vincent Noel , Dima Grigoriev , Sergei Vakulenko , Ovidiu Radulescu

Current mathematical frameworks for predicting the flux state and macromolecular composition of the cell do not rely on thermodynamic constraints to determine the spontaneous direction of reactions. These predictions may be biologically…

Optimization and Control · Mathematics 2020-08-14 Amir Akbari , Bernhard O. Palsson

The paper focuses on a multidimensional optimization problem, which is formulated in terms of tropical mathematics and consists in minimizing a nonlinear objective function subject to linear inequality constraints. To solve the problem, we…

Optimization and Control · Mathematics 2014-05-15 Nikolai Krivulin

We consider multidimensional optimization problems, which are formulated and solved in terms of tropical mathematics. The problems are to minimize (maximize) a linear or nonlinear function defined on vectors over an idempotent semifield,…

Optimization and Control · Mathematics 2024-01-18 N. Krivulin

Model reduction, which aims to learn a simpler model of the original mixed integer linear programming (MILP), can solve large-scale MILP problems much faster. Most existing model reduction methods are based on variable reduction, which…

Machine Learning · Computer Science 2026-02-04 Jiajun Li , Yixuan Li , Ran Hou , Yu Ding , Shisi Guan , Jiahui Duan , Xiongwei Han , Tao Zhong , Vincent Chau , Weiwei Wu , Wanyuan Wang

Many chemical processes exhibit diverse timescale dynamics with a strong coupling between timescale sensitive variables. Model predictive control with a non-uniformly spaced optimisation horizon is an effective approach to multi-timescale…

Systems and Control · Electrical Eng. & Systems 2022-05-11 Ryan McCloy , Lai Wei , Jie Bao

We consider optimization problems that are formulated and solved in the framework of tropical mathematics. The problems consist in minimizing or maximizing functionals defined on vectors of finite-dimensional semimodules over idempotent…

Optimization and Control · Mathematics 2014-08-05 Nikolai Krivulin

The paper presents a model reduction framework geared towards the analysis and design of systems that switch and oscillate. While such phenomena are ubiquitous in nature and engineering, model reduction methods are not well developed for…

Systems and Control · Electrical Eng. & Systems 2020-05-19 Alberto Padoan , Fulvio Forni , Rodolphe Sepulchre

We show that finding the classical bound of broad families of Bell inequalities can be naturally framed as the contraction of an associated tensor network, but in tropical algebra, where the sum is replaced by the minimum and the product is…

Quantum Physics · Physics 2026-02-13 Mengyao Hu , Jordi Tura

The theory of nonlinear balanced truncation provides a system-theoretic framework for model reduction that preserves important properties such as stability, controllability, and observability. We present a scalable algorithm for computing…

Optimization and Control · Mathematics 2026-04-28 Nicholas A. Corbin , Boris Kramer

Tropical differential equations are introduced and an algorithm is designed which tests solvability of a system of tropical linear differential equations within the complexity polynomial in the size of the system and in its coefficients.…

Symbolic Computation · Computer Science 2018-11-08 Dima Grigoriev

The determination of environmentally- and economically-optimal energy system designs and operations is complex. In particular, the integration of weather-dependent renewable energy technologies into energy system optimization models…

We review a range of reduction methods that have been, or may be useful for connecting models of the Earth's climate system of differing complexity. We particularly focus on methods where rigorous reduction is possible. We aim to highlight…

Dynamical Systems · Mathematics 2023-05-03 Felix Hummel , Peter Ashwin , Christian Kuehn

We consider a project that consists of activities to be performed in parallel under various temporal constraints, which include start-start, start-finish and finish-start precedence relationships, release times, deadlines, and due dates.…

Optimization and Control · Mathematics 2016-12-23 N. Krivulin

The description of complex physical phenomena often involves sophisticated models that rely on a large number of parameters, with many dimensions and scales. One practical way to simplify that kind of models is to discard some of the…

Soft Condensed Matter · Physics 2025-11-11 Simone Rusconi , Christina Schenk , Razvan Ceuca , Arghir Zarnescu , Elena Akhmatskaya

Biochemical molecules interact through modification and binding reactions, giving raise to a combinatorial number of possible biochemical species. The time-dependent evolution of concentrations of the species is commonly described by a…

Molecular Networks · Quantitative Biology 2019-03-22 Andreea Beica , Jérôme Feret , Tatjana Petrov

We propose a novel framework for model-order reduction of hyperbolic differential equations. The approach combines a relaxation formulation of the hyperbolic equations with a discretization using shifted base functions. Model-order…

Numerical Analysis · Mathematics 2021-05-03 Sara Grundel , Michael Herty

Techniques for simulating molecules whose conformations satisfy constraints are presented. A method for selecting appropriate moves in Monte Carlo simulations is given. The resulting moves not only obey the constraints but also maintain…

Computational Physics · Physics 2007-05-23 Charles F. F. Karney , Jason E. Ferrara

Chance constraints provide a principled framework to mitigate the risk of high-impact extreme events by modifying the controllable properties of a system. The low probability and rare occurrence of such events, however, impose severe…

Optimization and Control · Mathematics 2022-01-11 Shanyin Tong , Anirudh Subramanyam , Vishwas Rao

Optimization problems are considered in the framework of tropical algebra to minimize and maximize a nonlinear objective function defined on vectors over an idempotent semifield, and calculated using multiplicative conjugate transposition.…

Optimization and Control · Mathematics 2017-06-05 Nikolai Krivulin
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