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Traditional statistical methods for confidentiality protection of statistical databases do not scale well to deal with GWAS (genome-wide association studies) databases especially in terms of guarantees regarding protection from linkage to…

Methodology · Statistics 2012-05-04 Caroline Uhler , Aleksandra B. Slavkovic , Stephen E. Fienberg

The projected increase of genotyping in the clinic and the rise of large genomic databases has led to the possibility of using patient medical data to perform genomewide association studies (GWAS) on a larger scale and at a lower cost than…

Quantitative Methods · Quantitative Biology 2016-04-18 Sean Simmons , Cenk Sahinalp , Bonnie Berger

Genome-wide association studies (GWAS) are an essential tool in biomedical research for identifying genetic factors linked to health and disease. However, publicly releasing GWAS summary statistics poses well-recognized privacy risks,…

Quantitative Methods · Quantitative Biology 2025-12-05 Anupama Nandi , Seth Neel , Hyunghoon Cho

Genome-wide Association Studies (GWASes) identify genomic variations that are statistically associated with a trait, such as a disease, in a group of individuals. Unfortunately, careless sharing of GWAS statistics might give rise to privacy…

Genomics · Quantitative Biology 2022-09-21 Túlio Pascoal , Jérémie Decouchant , Antoine Boutet , Marcus Völp

Genome-wide association studies are pivotal in understanding the genetic underpinnings of complex traits and diseases. Collaborative, multi-site GWAS aim to enhance statistical power but face obstacles due to the sensitive nature of genomic…

Cryptography and Security · Computer Science 2025-12-12 Arjhun Swaminathan , Anika Hannemann , Ali Burak Ünal , Nico Pfeifer , Mete Akgün

As genomic research has grown increasingly popular in recent years, dataset sharing has remained limited due to privacy concerns. This limitation hinders the reproducibility and validation of research outcomes, both of which are essential…

Cryptography and Security · Computer Science 2025-04-02 Yuzhou Jiang , Tianxi Ji , Erman Ayday

One goal of statistical privacy research is to construct a data release mechanism that protects individual privacy while preserving information content. An example is a {\em random mechanism} that takes an input database $X$ and outputs a…

Statistics Theory · Mathematics 2012-01-11 Larry Wasserman , Shuheng Zhou

Genome-wide association studies (GWAS) identify correlations between the genetic variants and an observable characteristic such as a disease. Previous works presented privacy-preserving distributed algorithms for a federation of genome data…

Distributed, Parallel, and Cluster Computing · Computer Science 2022-09-21 Túlio Pascoal , Jérémie Decouchant , Marcus Völp

The increasing prevalence of high-dimensional data across various applications has raised significant privacy concerns in statistical inference. In this paper, we propose a differentially private integrated statistic for testing…

Methodology · Statistics 2025-06-04 Shiwei Sang , Yicheng Zeng , Xuehu Zhu , Shurong Zheng

Privacy-preserving genomic data sharing is prominent to increase the pace of genomic research, and hence to pave the way towards personalized genomic medicine. In this paper, we introduce ($\epsilon , T$)-dependent local differential…

Cryptography and Security · Computer Science 2021-02-16 Emre Yilmaz , Tianxi Ji , Erman Ayday , Pan Li

Disclosure avoidance (DA) systems are used to safeguard the confidentiality of data while allowing it to be analyzed and disseminated for analytic purposes. These methods, e.g., cell suppression, swapping, and k-anonymity, are commonly…

Cryptography and Security · Computer Science 2023-01-31 Keyu Zhu , Ferdinando Fioretto , Pascal Van Hentenryck , Saswat Das , Christine Task

Data stewards and analysts can promote transparent and trustworthy science and policy-making by facilitating assessments of the sensitivity of published results to alternate analysis choices. For example, researchers may want to assess…

Methodology · Statistics 2023-08-24 Chengxin Yang , Jerome P. Reiter

Motivated by understanding the dynamics of sensitive social networks over time, we consider the problem of continual release of statistics in a network that arrives online, while preserving privacy of its participants. For our privacy…

Cryptography and Security · Computer Science 2018-09-20 Shuang Song , Susan Little , Sanjay Mehta , Staal Vinterbo , Kamalika Chaudhuri

Providing provenance in scientific workflows is essential for reproducibility and auditability purposes. Workflow systems model and record provenance describing the steps performed to obtain the final results of a computation. In this work,…

Motivation: Researchers need a rich trove of genomic datasets that they can leverage to gain a better understanding of the genetic basis of the human genome and identify associations between phenotypes and specific parts of DNA. However,…

Cryptography and Security · Computer Science 2021-06-10 Nour Almadhoun Alserr , Gulce Kale , Onur Mutlu , Oznur Tastan , Erman Ayday

Following the publication of an attack on genome-wide association studies (GWAS) data proposed by Homer et al., considerable attention has been given to developing methods for releasing GWAS data in a privacy-preserving way. Here, we…

Machine Learning · Statistics 2014-07-31 Fei Yu , Michal Rybar , Caroline Uhler , Stephen E. Fienberg

In modern settings of data analysis, we may be running our algorithms on datasets that are sensitive in nature. However, classical machine learning and statistical algorithms were not designed with these risks in mind, and it has been…

Data Structures and Algorithms · Computer Science 2021-08-21 Huanyu Zhang

Unsupervised domain adaptation (UDA) generally aligns the unlabeled target domain data to the distribution of the source domain to mitigate the distribution shift problem. The standard UDA requires sharing the source data with the target,…

Computation and Language · Computer Science 2022-01-20 Qiyuan An , Ruijiang Li , Lin Gu , Hao Zhang , Qingyu Chen , Zhiyong Lu , Fei Wang , Yingying Zhu

While the introduction of differential privacy has been a major breakthrough in the study of privacy preserving data publication, some recent work has pointed out a number of cases where it is not possible to limit inference about…

Databases · Computer Science 2012-02-16 Ada Wai-Chee Fu , Jia Wang , Ke Wang , Raymond Chi-Wing Wong

We consider a problem where mutually untrusting curators possess portions of a vertically partitioned database containing information about a set of individuals. The goal is to enable an authorized party to obtain aggregate (statistical)…

Cryptography and Security · Computer Science 2013-04-18 Bing-Rong Lin , Ye Wang , Shantanu Rane
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