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Supervised deep learning relies on the assumption that enough training data is available, which presents a problem for its application to several fields, like medical imaging. On the example of a binary image classification task (breast…

Computer Vision and Pattern Recognition · Computer Science 2019-02-22 Lukas Jendele , Ondrej Skopek , Anton S. Becker , Ender Konukoglu

Accurate screening of cancer types is crucial for effective cancer detection and precise treatment selection. However, the association between gene expression profiles and tumors is often limited to a small number of biomarker genes. While…

Neural and Evolutionary Computing · Computer Science 2024-04-09 Xubin Wang , Yunhe Wang , Zhiqing Ma , Ka-Chun Wong , Xiangtao Li

In recent studies, non-coding protein RNAs have been identified as microRNA that can be used as biomarkers for early diagnosis and treatment of cancer, that decrease mortality in cancer. A microRNA may target hundreds or thousands of genes…

Genomics · Quantitative Biology 2019-03-06 Sepideh Shamsizadeh , Sama Goliaei , Zahra Razaghi Moghadam

In this work we suggest a statistical mechanics approach to the classification of high-dimensional data according to a binary label. We propose an algorithm whose aim is twofold: First it learns a classifier from a relatively small number…

Statistical Mechanics · Physics 2009-07-22 Andrea Pagnani , Francesca Tria , Martin Weigt

The recent development of imaging and sequencing technologies enables systematic advances in the clinical study of lung cancer. Meanwhile, the human mind is limited in effectively handling and fully utilizing the accumulation of such…

Machine Learning · Computer Science 2022-03-29 Yawei Li , Xin Wu , Ping Yang , Guoqian Jiang , Yuan Luo

This work contributes to breast cancer sub-type classification using histopathological images. We utilize masked autoencoders (MAEs) to learn a self-supervised embedding tailored for computer vision tasks in this domain. This embedding…

Computer Vision and Pattern Recognition · Computer Science 2025-06-10 Annalisa Chiocchetti , Marco Dossena , Christopher Irwin , Luigi Portinale

Background and Aim: Over-fitting issue has been the reason behind deep learning technology not being successfully implemented in oral cancer images classification. The aims of this research were reducing overfitting for accurately producing…

Image and Video Processing · Electrical Eng. & Systems 2022-08-17 Prakrit Joshi , Omar Hisham Alsadoon , Abeer Alsadoon , Nada AlSallami , Tarik A. Rashid , P. W. C. Prasad , Sami Haddad

Multi-state models of cancer natural history are widely used for designing and evaluating cancer early detection strategies. Calibrating such models against longitudinal data from screened cohorts is challenging, especially when fitting…

Computation · Statistics 2025-08-14 Raphael Morsomme , Shannon Holloway , Marc Ryser , Jason Xu

Purpose: To determine whether deep learning models can distinguish between breast cancer molecular subtypes based on dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI). Materials and methods: In this institutional review…

Computer Vision and Pattern Recognition · Computer Science 2017-12-01 Zhe Zhu , Ehab Albadawy , Ashirbani Saha , Jun Zhang , Michael R. Harowicz , Maciej A. Mazurowski

This research presents a machine-learning approach for tumor detection in medical images using convolutional neural networks (CNNs). The study focuses on preprocessing techniques to enhance image features relevant to tumor detection,…

Image and Video Processing · Electrical Eng. & Systems 2024-03-01 Ha Anh Vu

The training of medical image analysis systems using machine learning approaches follows a common script: collect and annotate a large dataset, train the classifier on the training set, and test it on a hold-out test set. This process bears…

Computer Vision and Pattern Recognition · Computer Science 2019-02-05 Gabriel Maicas , Andrew P. Bradley , Jacinto C. Nascimento , Ian Reid , Gustavo Carneiro

Recent advancements in image classification have demonstrated that contrastive learning (CL) can aid in further learning tasks by acquiring good feature representation from a limited number of data samples. In this paper, we applied CL to…

Machine Learning · Computer Science 2024-10-22 Anchen Sun , Elizabeth J. Franzmann , Zhibin Chen , Xiaodong Cai

Gene expression analysis aims at identifying the genes able to accurately predict biological parameters like, for example, disease subtyping or progression. While accurate prediction can be achieved by means of many different techniques,…

Methodology · Statistics 2008-09-11 Christine De Mol , Sofia Mosci , Magali Traskine , Alessandro Verri

Motivation. Understanding the pan-cancer mutational landscape offers critical insights into the molecular mechanisms underlying tumorigenesis. While patient-level machine learning techniques have been widely employed to identify tumor…

Machine Learning · Computer Science 2025-08-29 Yifan Dou , Adam Khadre , Ruben C Petreaca , Golrokh Mirzaei

Electronic health records contain inconsistently structured or free-text data, requiring efficient preprocessing to enable predictive health care models. Although artificial intelligence-driven natural language processing tools show promise…

In recent studies, non-coding protein RNAs have been identified as microRNA that can be used as biomarkers for early diagnosis and treatment of cancer, that decrease mortality in cancer. A microRNA may target hundreds or thousands of genes…

Computational Engineering, Finance, and Science · Computer Science 2018-06-20 Sepideh Shamsizadeha , Sama Goliaea , Zahra Razaghi Moghadamb

Motivation: Microarray data has been recently been shown to be efficacious in distinguishing closely related cell types that often appear in the diagnosis of cancer. It is useful to determine the minimum number of genes needed to do such a…

Biological Physics · Physics 2007-05-23 J. M. Deutsch

Normalization is a critical step in quantitative analyses of biological processes. Recent works show that cross-platform integration and normalization enable machine learning (ML) training on RNA microarray and RNA-seq data, but no…

Quantitative Methods · Quantitative Biology 2025-05-30 Fei Deng , Catherine H Feng , Nan Gao , Lanjing Zhang

Automated diagnostic assistants in healthcare necessitate accurate AI models that can be trained with limited labeled data, can cope with severe class imbalances and can support simultaneous prediction of multiple disease conditions. To…

Computer Vision and Pattern Recognition · Computer Science 2021-02-11 Deepta Rajan , Jayaraman J. Thiagarajan , Alexandros Karargyris , Satyananda Kashyap

The discovery of important biomarkers is a significant step towards understanding the molecular mechanisms of carcinogenesis; enabling accurate diagnosis for, and prognosis of, a certain cancer type. Before recommending any diagnosis,…

Quantitative Methods · Quantitative Biology 2019-09-11 Md. Rezaul Karim , Michael Cochez , Oya Beyan , Stefan Decker , Christoph Lange
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