Related papers: Derivation of a Hele-Shaw type system from a cell …
Models of tumor growth, now commonly used, present several levels of complexity, both in terms of the biomedical ingredients and the mathematical description. The simplest ones contain competition for space using purely fluid mechanical…
The mathematical modeling of tumor growth leads to singular stiff pressure law limits for porous medium equations with a source term. Such asymptotic problems give rise to free boundaries, which, in the absence of active motion, are…
In this paper, we study the tumor growth equation along with various models for the nutrient component, including the \emph{in vitro} model and the \emph{in vivo} model. At the cell density level, the spatial availability of the tumor…
We consider weak solutions to a problem modeling tumor growth. Under certain conditions on the initial data, solutions can be obtained by passing to the stiff (incompressible) limit in a porous medium type problem with a Lotka-Volterra…
We study the incompressible limit of the porous medium equation with a right hand side representing either a source or a sink term, and an injection boundary condition. This model can be seen as a simplified description of non-monotone…
We investigate the large time behavior of an agent based model describing tumor growth. The microscopic model combines short-range repulsion and cell division. As the number of cells increases exponentially in time, the microscopic model is…
A mathematical model for tissue growth is considered. This model describes the dynamics of the density of cells due to pressure forces and proliferation. It is known that such cell population model converges at the incompressible limit…
Both compressible and incompressible porous medium models are used in the literature to describe the mechanical properties of living tissues. These two classes of models can be related using a stiff pressure law. In the incompressible…
In this paper, we propose a tumor growth model to incorporate and investigate the spatial effects of autophagy. The cells are classified into two phases: normal cells and autophagic cells, whose dynamics are also coupled with the nutrients.…
This paper proposes a model for the growth two interacting populations of cells that do not mix. The dynamics is driven by pressure and cohesion forces on the one hand and proliferation on the other hand. Following earlier works on the…
In this paper we study the "stiff pressure limit" of the porous medium equation, where the initial density is a bounded, integrable function with a sufficient decay at infinity. Our particular model, introduced by Perthame-Quiros-Vazquez,…
We analyze a system of cross-diffusion equations that models the growth of an avascular-tumor spheroid. The model incorporates two nonlinear diffusion effects, degeneracy type and super diffusion. We prove the global existence of weak…
We consider a model of congestion dynamics with chemotaxis, where the density of cells follows the chemical signal it generates, while observing an incompressibility constraint. We show that when the chemical diffuses slowly and attracts…
In this paper, we consider an age-structured mechanical model for tumor growth. This model takes into account the life-cycle of tumor cells by including an age variable. The underlying process for tumor growth is the same as classical tumor…
At the continuous level, we consider two types of tumor growth models: the cell density model, which is based on the fluid mechanical construction, is more favorable for scientific interpretation and numerical simulations; and the free…
We consider a diffuse interface model for tumor growth recently proposed in [Y. Chen, S.M. Wise, V.B. Shenoy, J.S. Lowengrub, A stable scheme for a nonlinear, multiphase tumor growth model with an elastic membrane, Int. J. Numer. Methods…
Various models of tumor growth are available in the litterature. A first class describes the evolution of the cell number density when considered as a continuous visco-elastic material with growth. A second class, describes the tumor as a…
We consider a Hele-Shaw model that describes tumor growth subject to nutrient supply. The model is derived by taking the incompressible limit of porous medium type equations, and the boundary instability of this model was recently studied…
We introduce a two-dimensional Hele-Shaw type free boundary model for motility of eukaryotic cells on substrates. The key ingredients of this model are the Darcy law for overdamped motion of the cytoskeleton gel (active gel) coupled with…
We consider a diffuse interface model for tumor growth consisting of a Cahn--Hilliard equation with source terms coupled to a reaction-diffusion equation, which models a tumor growing in the presence of a nutrient species and surrounded by…