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We propose a novel deep learning method which combines classical regularization with data augmentation for estimating myelin water fraction (MWF) in the brain via biexponential analysis. Our aim is to design an accurate deep learning…

Quantitative Methods · Quantitative Biology 2025-01-31 Mirage Modi , Shashank Sule , Jonathan Palumbo , Michael Rozowski , Mustapha Bouhrara , Wojciech Czaja , Richard G. Spencer

Foundation models provide robust embeddings for diverse tasks, including medical imaging. We evaluate embeddings from seven general and medical-specific foundation models (e.g., DenseNet121, BiomedCLIP, MedImageInsight, Rad-DINO,…

Foundation models (FMs) are pre-trained on large-scale datasets and then fine-tuned for a specific downstream task. The most common fine-tuning method is to update pretrained weights via low-rank adaptation (LoRA). Existing initialization…

Machine Learning · Computer Science 2025-10-21 Fabian Paischer , Lukas Hauzenberger , Thomas Schmied , Benedikt Alkin , Marc Peter Deisenroth , Sepp Hochreiter

Large Language Models (LLMs) demand substantial computational resources, resulting in high energy consumption on GPUs. To address this challenge, we focus on Coarse-Grained Reconfigurable Arrays (CGRAs) as an effective alternative that…

Hardware Architecture · Computer Science 2025-12-02 Takuto Ando , Yu Eto , Ayumu Takeuchi , Yasuhiko Nakashima

Recently, there has been a growing trend in utilizing large language models (LLMs) for recommender systems, referred to as LLMRec. A notable approach within this trend is not to fine-tune these models directly but instead to leverage…

Information Retrieval · Computer Science 2025-04-08 Yi Xu , Weicong Qin , Weijie Yu , Ming He , Jianping Fan , Jun Xu

Recent neural theorem provers use reinforcement learning with verifiable rewards (RLVR), where proof assistants provide binary correctness signals. While verifiable rewards are cheap and scalable without reward hacking issues, they suffer…

Artificial Intelligence · Computer Science 2026-05-12 Zeynel A. Uluşan , Burak S. Akbudak , Can S. Erer , Gözde Gül Şahin

Reward models are central to aligning language models with human preferences via reinforcement learning (RL). As RL is increasingly applied to settings such as verifiable rewards and multi-objective alignment, RMs are expected to encode…

Machine Learning · Computer Science 2026-05-21 Jiwoo Hong , Shao Tang , Zhipeng Wang

Fine-tuning large-scale pretrained models is prohibitively expensive in terms of computational and memory costs. LoRA, as one of the most popular Parameter-Efficient Fine-Tuning (PEFT) methods, offers a cost-effective alternative by…

Machine Learning · Computer Science 2024-07-17 Shaowen Wang , Linxi Yu , Jian Li

Graph matching, typically formulated as a Quadratic Assignment Problem (QAP), seeks to establish node correspondences between two graphs. To address the NP-hardness of QAP, some existing methods adopt projection-based relaxations that embed…

Machine Learning · Computer Science 2025-08-05 Binrui Shen , Yuan Liang , Shengxin Zhu

With the increasing size of pre-trained language models (PLMs), fine-tuning all the parameters in the model is not efficient, especially when there are a large number of downstream tasks, which incur significant training and storage costs.…

Computation and Language · Computer Science 2023-08-24 Feiyu Zhang , Liangzhi Li , Junhao Chen , Zhouqiang Jiang , Bowen Wang , Yiming Qian

Fast Radio Bursts (FRBs), a class of millisecond-scale, highly energetic phenomena with unknown progenitors and radiation mechanisms, require proper statistical analysis as a key method for uncovering their mysteries. In this research, we…

High Energy Astrophysical Phenomena · Physics 2025-02-27 Xianghan Cui , Clancy James , Di Li , Chengmin Zhang

Mixture models with Gamma and or inverse-Gamma distributed mixture components are useful for medical image tissue segmentation or as post-hoc models for regression coefficients obtained from linear regression within a Generalised Linear…

Machine Learning · Statistics 2016-07-27 A. Llera , D. Vidaurre , R. H. R. Pruim , C. F. Beckmann

Multivariate linear mixed models (mvLMMs) have been widely used in many areas of genetics, and have attracted considerable recent interest in genome-wide association studies (GWASs). However, fitting mvLMMs is computationally non-trivial,…

Quantitative Methods · Quantitative Biology 2013-09-13 Xiang Zhou , Matthew Stephens

Fine-tuning Large Language Models (LLMs) has become a crucial technique for adapting pre-trained models to downstream tasks. However, the enormous size of LLMs poses significant challenges in terms of computational complexity and resource…

Computation and Language · Computer Science 2024-10-28 Yifei Zhang , Hao Zhu , Aiwei Liu , Han Yu , Piotr Koniusz , Irwin King

Summary: We present a new tool to correct sequencing errors in Illumina data produced from high-coverage whole-genome shotgun resequencing. It uses a non-greedy algorithm and shows comparable performance and higher accuracy in an evaluation…

Genomics · Quantitative Biology 2015-02-13 Heng Li

Progress in LLMs is increasingly measured through standardized benchmarks, where state-of-the-art improvements are often separated by fractions of a percentage point. At the same time, the computational cost of evaluating modern LLMs has…

Machine Learning · Computer Science 2026-05-21 David Pape , Jonathan Evertz , Lea Schönherr

Functional Magnetic Resonance Imaging(fMRI) has now become a classic way for measuring brain activity, and recent trend is shifting toward utilizing fMRI brain data for AI-driven diagnosis. Given that the brain functions as not a discrete…

Machine Learning · Computer Science 2026-03-17 Minkyung Cha , Jooyoung Bae , Jaewon Jung , Ping Shu Ho , Ka Chun Cheung , Namjoon Kim

Gene regulatory network (GRN) modeling is a well-established theoretical framework for the study of cell-fate specification during developmental processes. Recently, dynamical models of GRNs have been taken as a basis for formalizing the…

Molecular Networks · Quantitative Biology 2015-10-15 Jose Davila-Velderrain , Luis Juarez-Ramiro , Juan C. Martinez-Garcia , Elena R. Alvarez-Buylla

The increasing deployment of Internet-of-Things (IoT)-enabled measurement devices in modern power systems has expanded the cyberattack surface of the grid. As a result, this critical infrastructure is increasingly exposed to cyberattacks,…

Machine Learning · Computer Science 2026-01-28 Ruslan Abdulin , Mohammad Rasoul Narimani

Generalized linear mixed models (GLMM) encompass large class of statistical models, with a vast range of applications areas. GLMM extends the linear mixed models allowing for different types of response variable. Three most common data…

Applications · Statistics 2017-04-25 Wagner Hugo Bonat , Paulo Justiniano Ribeiro , Silvia emiko Shimakura