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Pulsar candidate sifting is an essential process for discovering new pulsars. It aims to search for the most promising pulsar candidates from an all-sky survey, such as High Time Resolution Universe (HTRU), Green Bank Northern Celestial Cap…

Instrumentation and Methods for Astrophysics · Physics 2023-12-27 Haitao Lin , Xiangru Li , Qingguo Zeng

Algorithms that detect covariance between pairs of columns in multiple sequence alignments are commonly employed to predict functionally important residues and structural contacts. However, the assumption that co-variance only occurs…

Quantitative Methods · Quantitative Biology 2014-01-07 Kyle E. Kreth , Anthony A. Fodor

Next-generation sequencing techniques have facilitated a large scale analysis of human genetic variation. Despite the advances in sequencing speeds, the computational discovery of structural variants is not yet standard. It is likely that…

The idea that structural disorder might be a novel mechanism of protein interaction is widespread in the Literature, although the number of statistically significant structural studies supporting this is surprisingly low. At variance with…

Disordered Systems and Neural Networks · Physics 2021-03-01 Beatriz Seoane , Alessandra Carbone

In genomics, pattern matching against a sequence of nucleotides plays a pivotal role for DNA sequence alignment and comparing genomes. This helps tackling some diseases, such as cancer in humans. The complexity of searching biological…

Quantitative Methods · Quantitative Biology 2017-10-04 Fereshte Mozafari , Hossein Babashah , Somayyeh Koohi , Zahra Kavehvash

Large language models (LLMs) struggle on processing complicated observations in interactive decision making tasks. To alleviate this issue, we propose a simple hierarchical prompting approach. Diverging from previous prompting approaches…

Computation and Language · Computer Science 2023-10-31 Abishek Sridhar , Robert Lo , Frank F. Xu , Hao Zhu , Shuyan Zhou

Process discovery aims to automatically derive process models from event logs, enabling organizations to analyze and improve their operational processes. Inductive mining algorithms, while prioritizing soundness and efficiency through…

Artificial Intelligence · Computer Science 2025-09-22 Humam Kourani , Gyunam Park , Wil M. P. van der Aalst

Visual design tasks often involve tuning many design parameters. For example, color grading of a photograph involves many parameters, some of which non-expert users might be unfamiliar with. We propose a novel user-in-the-loop optimization…

Graphics · Computer Science 2020-05-11 Yuki Koyama , Issei Sato , Masataka Goto

Searching for local sequence patterns is one of the basic tasks in bioinformatics. Sequence patterns might have structural, functional or some other relevance, and numerous methods have been developed to detect and analyze them. These…

Quantitative Methods · Quantitative Biology 2018-08-01 Braslav Rabar , Strahil Ristov , Maja Zagorščak , Martin Rosenzweig , Pavle Goldstein

Searching for novel molecular compounds with desired properties is an important problem in drug discovery. Many existing frameworks generate molecules one atom at a time. We instead propose a flexible editing paradigm that generates…

Biomolecules · Quantitative Biology 2021-11-02 Benson Chen , Xiang Fu , Regina Barzilay , Tommi Jaakkola

Given a textual passage and an answer, humans are able to ask questions with various expressions, but this ability is still challenging for most question generation (QG) systems. Existing solutions mainly focus on the internal knowledge…

Computation and Language · Computer Science 2023-10-24 Qi Gou , Zehua Xia , Bowen Yu , Haiyang Yu , Fei Huang , Yongbin Li , Nguyen Cam-Tu

Effective cyber threat recognition and prevention demand comprehensible forecasting systems, as prior approaches commonly offer limited and, ultimately, unconvincing information. We introduce Simplified Plaintext Language (SPLAIN), a…

Computation and Language · Computer Science 2023-11-27 Vera A. Kazakova , Jena D. Hwang , Bonnie J. Dorr , Yorick Wilks , J. Blake Gage , Alex Memory , Mark A. Clark

Building natural language interfaces typically uses a semantic parser to parse the user's natural language and convert it into structured \textbf{S}emantic \textbf{L}ogic \textbf{F}orms (SLFs). The mainstream approach is to adopt a…

Computation and Language · Computer Science 2024-04-01 Hao Wu , Fan Xu

The remarkable structural diversity of modern proteins reflects millions of years of evolution, during which sequence space has expanded while many structural features remain conserved. This conservation is evident not only among homologous…

Prediction of ligand binding sites of proteins is a fundamental and important task for understanding the function of proteins and screening potential drugs. Most existing methods require experimentally determined protein holo-structures as…

Quantitative Methods · Quantitative Biology 2023-12-07 Shuo Zhang , Lei Xie

The Invertible Bloom Lookup Table (IBLT) is a probabilistic concise data structure for set representation that supports a listing operation as the recovery of the elements in the represented set. Its applications can be found in network…

Information Theory · Computer Science 2022-12-29 Avi Mizrahi , Daniella Bar-Lev , Eitan Yaakobi , Ori Rottenstreich

We present a sequence-based probabilistic formalism that directly addresses co-operative effects in networks of interacting positions in proteins, providing significantly improved contact prediction, as well as accurate quantitative…

Quantitative Methods · Quantitative Biology 2012-07-12 Alan Lapedes , Bertrand Giraud , Christopher Jarzynski

The immense amount of time series data produced by astronomical surveys has called for the use of machine learning algorithms to discover and classify several million celestial sources. In the case of variable stars, supervised learning…

Solar and Stellar Astrophysics · Physics 2022-10-12 R. Pantoja , M. Catelan , K. Pichara , P. Protopapas

Explanations in a recommender system assist users in making informed decisions among a set of recommended items. Great research attention has been devoted to generating natural language explanations to depict how the recommendations are…

Information Retrieval · Computer Science 2022-02-22 Peng Wang , Renqin Cai , Hongning Wang

Cells of diatoms and related algae with complex plastids of red algal origin are highly compartmentalized. These plastids are surrounded by four envelope membranes, which also define the periplastidic compartment (PPC), the space between…

Subcellular Processes · Quantitative Biology 2026-01-28 Ansgar Gruber , Cedar McKay , Miroslav Oborník , Gabrielle Rocap