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The number of extant individuals within a lineage, as exemplified by counts of species numbers across genera in a higher taxonomic category, is known to be a highly skewed distribution. Because the sublineages (such as genera in a clade)…

Applications · Statistics 2009-01-09 Panagis Moschopoulos , Max Shpak

Recently, combinations of generative and Bayesian machine learning have been introduced in particle physics for both fast detector simulation and inference tasks. These neural networks aim to quantify the uncertainty on the generated…

Machine Learning · Computer Science 2024-11-21 Sebastian Bieringer , Sascha Diefenbacher , Gregor Kasieczka , Mathias Trabs

Fixed tree topologies are widely used in phylodynamic analyses to reduce computational burden, yet the consequences of this assumption remain insufficiently understood. Here, we systematically assess the impact of various fixed-topology…

Populations and Evolution · Quantitative Biology 2025-12-01 Mathieu Fourment , Jiansi Gao , Marc A Suchard , Frederick A Matsen

When facing uncertainty, decision-makers want predictions they can trust. A machine learning provider can convey confidence to decision-makers by guaranteeing their predictions are distribution calibrated -- amongst the inputs that receive…

Machine Learning · Statistics 2021-07-14 Shengjia Zhao , Michael P. Kim , Roshni Sahoo , Tengyu Ma , Stefano Ermon

The classification of imbalanced data has presented a significant challenge for most well-known classification algorithms that were often designed for data with relatively balanced class distributions. Nevertheless skewed class distribution…

Machine Learning · Statistics 2023-04-21 Jiaju Miao , Wei Zhu

The use of mathematical models to make predictions about tumor growth and response to treatment has become increasingly more prevalent in the clinical setting. The level of complexity within these models ranges broadly, and the calibration…

Quantitative Methods · Quantitative Biology 2021-12-28 Allison L. Lewis , Kathleen M. Storey , Heyrim Cho , Anna C. Zittle

Phylogenetic tree shapes capture fundamental signatures of evolution. We consider ``ranked'' tree shapes, which are equipped with a total order on the internal nodes compatible with the tree graph. Recent work has established an elegant…

Populations and Evolution · Quantitative Biology 2026-03-10 Chris Jennings-Shaffer , Ziyue , Chen , Julia A Palacios , Frederick A Matsen

Variable selection and classification are common objectives in the analysis of high-dimensional data. Most such methods make distributional assumptions that may not be compatible with the diverse families of distributions data can take. A…

Methodology · Statistics 2019-08-28 Weichang Yu , Lamiae Azizi , John T. Ormerod

Variable-length Markov chains (VLMCs) are a flexible class of higher-order Markov models that admit a natural representation as context trees. Existing Bayesian methods for specifying prior distributions on tree structures rely on branching…

Methodology · Statistics 2026-05-11 Thiago Paulichen , Victor Freguglia

The recursive and hierarchical structure of full rooted trees is applicable to represent statistical models in various areas, such as data compression, image processing, and machine learning. In most of these cases, the full rooted tree is…

Machine Learning · Statistics 2022-03-24 Yuta Nakahara , Shota Saito , Akira Kamatsuka , Toshiyasu Matsushima

Nested dichotomies are used as a method of transforming a multiclass classification problem into a series of binary problems. A tree structure is induced that recursively splits the set of classes into subsets, and a binary classification…

Machine Learning · Computer Science 2018-10-04 Tim Leathart , Eibe Frank , Bernhard Pfahringer , Geoffrey Holmes

For a model of molecular evolution to be useful for phylogenetic inference, the topology of evolutionary trees must be identifiable. That is, from a joint distribution the model predicts, it must be possible to recover the tree parameter.…

Populations and Evolution · Quantitative Biology 2011-11-09 Elizabeth S. Allman , John A. Rhodes

The homogeneous reconstructed evolutionary process is a birth-death process without observed extinct lineages. Each species evolves independently with the same diversification rates (speciation rate $\lambda(t)$ and extinction rate…

Populations and Evolution · Quantitative Biology 2014-02-12 Sebastian Höhna

Approximate Bayesian computation (ABC) methods provide an elaborate approach to Bayesian inference on complex models, including model choice. Both theoretical arguments and simulation experiments indicate, however, that model posterior…

Establishing that a set of population-splitting events occurred at the same time can be a potentially persuasive argument that a common process affected the populations. Oaks et al. (2013) assessed the ability of an approximate-Bayesian…

Populations and Evolution · Quantitative Biology 2014-11-26 Jamie R. Oaks , Charles W. Linkem , Jeet Sukumaran

Confidence calibration of classification models is a technique to estimate the true posterior probability of the predicted class, which is critical for ensuring reliable decision-making in practical applications. Existing confidence…

Methodology · Statistics 2025-02-19 Jinzong Dong , Zhaohui Jiang , Dong Pan , Haoyang Yu

Computational inference of dated evolutionary histories relies upon various hypotheses about RNA, DNA, and protein sequence mutation rates. Using mutation rates to infer these dated histories is referred to as molecular clock assumption.…

Populations and Evolution · Quantitative Biology 2021-01-11 Lena Collienne , Kieran Elmes , Mareike Fischer , David Bryant , Alex Gavryushkin

The age of the root of the Indo-European language family has received much attention since the application of Bayesian phylogenetic methods by Gray and Atkinson(2003). The root age of the Indo-European family has tended to decrease from an…

Computation and Language · Computer Science 2018-05-11 Taraka Rama

Traditionally, phylogeny and sequence alignment are estimated separately: first estimate a multiple sequence alignment and then infer a phylogeny based on the sequence alignment estimated in the previous step. However, uncertainty in the…

Applications · Statistics 2014-11-25 Heejung Shim , Bret Larget

As we move away from the data, the predictive uncertainty should increase, since a great variety of explanations are consistent with the little available information. We introduce Distance-Aware Prior (DAP) calibration, a method to correct…

Machine Learning · Statistics 2022-07-19 Gianluca Detommaso , Alberto Gasparin , Andrew Wilson , Cedric Archambeau