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The movement of a particle described by Brownian motion is quantified by a single parameter, $D$, the diffusion constant. The estimation of $D$ from a discrete sequence of noisy observations is a fundamental problem in biological single…

Subcellular Processes · Quantitative Biology 2016-04-13 Peter K. Relich , Mark J. Olah , Patrick J. Cutler , Keith A. Lidke

We propose and study properties of maximum likelihood estimators in the class of conditional transformation models. Based on a suitable explicit parameterisation of the unconditional or conditional transformation function, we establish a…

Methodology · Statistics 2019-10-22 Torsten Hothorn , Lisa Möst , Peter Bühlmann

This paper studies the problem of estimation from relative measurements in a graph, in which a vector indexed over the nodes has to be reconstructed from pairwise measurements of differences between its components associated to nodes…

Systems and Control · Computer Science 2018-07-27 Chiara Ravazzi , Nelson P. K. Chan , Paolo Frasca

This paper rigorously establishes that the existence of the maximum likelihood estimate (MLE) in high-dimensional logistic regression models with Gaussian covariates undergoes a sharp `phase transition'. We introduce an explicit boundary…

Methodology · Statistics 2018-04-27 Emmanuel J. Candes , Pragya Sur

In this paper, we derive a stability result for $L_1$ and $L_{\infty}$ perturbations of diffusions under weak regularity conditions on the coefficients. In particular, the drift terms we consider can be unbounded with at most linear growth,…

Probability · Mathematics 2021-04-02 Ilya Bitter , Valentin Konakov

The robust improper maximum likelihood estimator (RIMLE) is a new method for robust multivariate clustering finding approximately Gaussian clusters. It maximizes a pseudo-likelihood defined by adding a component with improper constant…

Methodology · Statistics 2018-02-14 Pietro Coretto , Christian Hennig

Linear birth-and-death processes (LBDPs) are foundational stochastic models in population dynamics, evolutionary biology, and hematopoiesis. Estimating parameters from discretely observed data is computationally demanding due to irregular…

Computation · Statistics 2025-08-26 Xiaochen Long , Marek Kimmel

We propose a new statistical observation scheme of diffusion processes named convolutional observation, where it is possible to deal with smoother observation than ordinary diffusion processes by considering convolution of diffusion…

Statistics Theory · Mathematics 2020-10-28 Shogo H Nakakita , Masayuki Uchida

Diffusion Large Language Models (dLLMs) support arbitrary-order generation, yet their inference performance critically depends on the unmasking order. Existing strategies rely on heuristics that greedily optimize local confidence, offering…

Machine Learning · Computer Science 2026-02-04 Xuejie Liu , Yap Vit Chun , Yitao Liang , Anji Liu

To sample from an unconditionally trained Denoising Diffusion Probabilistic Model (DDPM), classifier guidance adds conditional information during sampling, but the gradients from classifiers, especially those not trained on noisy images,…

Machine Learning · Computer Science 2024-06-26 Philipp Vaeth , Alexander M. Fruehwald , Benjamin Paassen , Magda Gregorova

In Positron Emission Tomography, movement leads to blurry reconstructions when not accounted for. Whether known a priori or estimated jointly to reconstruction, motion models are increasingly defined in continuum rather that in discrete,…

Optimization and Control · Mathematics 2021-07-22 Camille Pouchol , Olivier Verdier

Single-molecule localization microscopy allows practitioners to locate and track labeled molecules in biological systems. When extracting diffusion coefficients from the resulting trajectories, it is common practice to perform a linear fit…

Biological Physics · Physics 2024-06-19 Jakob Tómas Bullerjahn , Gerhard Hummer

In this letter, we employ and design the expectation--conditional maximization either (ECME) algorithm, a generalisation of the EM algorithm, for solving the maximum likelihood direction finding problem of stochastic sources, which may be…

Signal Processing · Electrical Eng. & Systems 2025-08-05 Ming-yan Gong , Bin Lyu

The problem of nonlinear functional of parameters, such as differential entropy, has received much attention in information theory and statistics. In many situations, prior information about the parameters is available in the form of order…

Statistics Theory · Mathematics 2026-03-10 Somnath Mandal , Lakshmi Kanta Patra

A weighted likelihood technique for robust estimation of a multivariate Wrapped Normal distribution for data points scattered on a p-dimensional torus is proposed. The occurrence of outliers in the sample at hand can badly compromise…

Methodology · Statistics 2021-07-01 Giovanni Saraceno , Claudio Agostinelli , Luca Greco

A central problem in uncertainty quantification is how to characterize the impact that our incomplete knowledge about models has on the predictions we make from them. This question naturally lends itself to a probabilistic formulation, by…

Statistical Mechanics · Physics 2018-09-03 Giovanni Dematteis , Tobias Grafke , Eric Vanden-Eijnden

The application machine learning (ML) algorithms to turbulence modeling has shown promise over the last few years, but their application has been restricted to eddy viscosity based closure approaches. In this article we discuss rationale…

Fluid Dynamics · Physics 2021-05-31 J. P. Panda , H. V. Warrior

Consider a setting with $N$ independent individuals, each with an unknown parameter, $p_i \in [0, 1]$ drawn from some unknown distribution $P^\star$. After observing the outcomes of $t$ independent Bernoulli trials, i.e., $X_i \sim…

Statistics Theory · Mathematics 2019-02-13 Ramya Korlakai Vinayak , Weihao Kong , Gregory Valiant , Sham M. Kakade

Hawkes Processes have undergone increasing popularity as default tools for modeling self- and mutually exciting interactions of discrete events in continuous-time event streams. A Maximum Likelihood Estimation (MLE) unconstrained…

Machine Learning · Computer Science 2021-05-11 Rafael Lima

The traffic matrix estimation (TME) problem has been widely researched for decades of years. Recent progresses in deep generative models offer new opportunities to tackle TME problems in a more advanced way. In this paper, we leverage the…

Machine Learning · Computer Science 2024-10-22 Xinyu Yuan , Yan Qiao , Pei Zhao , Rongyao Hu , Benchu Zhang