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Current scientific consensus holds that sound is transmitted, solely mechanically, from the tympanum to the cochlea via ossicles. But this theory does not explain the hearing extreme quality regarding high frequencies in mammals. So, we…

Current scientific consensus holds that sound is transmitted, solely mechanically, from the tympanum to the cochlea via ossicles. However this theory does not explain the hearing extreme quality regarding high frequencies in mammals. So, we…

A mathematical model describing the coupling between two independent amplification mechanisms in auditory hair cells is proposed and analyzed. Hair cells are cells in the inner ear responsible for translating sound-induced mechanical…

Pattern Formation and Solitons · Physics 2009-11-13 K. A. Montgomery , M. Silber , S. A. Solla

The ability of the mammalian ear in processing high frequency sounds, up to $\sim$100 kHz, is based on the capability of outer hair cells (OHCs) responding to stimulation at high frequencies. These cells show a unique motility in their cell…

Biological Physics · Physics 2017-09-22 Kuni H Iwasa

A hearing sensation arises when the elastic basilar membrane inside the cochlea vibrates. The basilar membrane is typically set into motion through airborne sound that displaces the middle ear and induces a pressure difference across the…

Quantitative Methods · Quantitative Biology 2015-06-22 T. Tchumatchenko , T. Reichenbach

A new theory of mammalian hearing is presented, which accounts for the auditory image in the midbrain (inferior colliculus) of objects in the acoustical environment of the listener. It is shown that the ear is a temporal imaging system that…

Neurons and Cognition · Quantitative Biology 2024-06-04 Adam Weisser

This work reviews the human auditory system, elucidating some of the specialized mechanisms and non-linear pathways along the chain of events between physical sound and its perception. Customary relationships between frequency, time, and…

Neurons and Cognition · Quantitative Biology 2023-08-01 Milind N. Kunchur

Outer hair cells (OHCs) are essential for the sensitivity and frequency specificity of the mammalian ear. To perform this function, OHCs need to amplify the motion of the basilar membrane (BM), which is much stiffer than themselves. If OHCs…

Biological Physics · Physics 2026-02-05 Kuni H. Iwasa

The sensitivity and frequency selectivity of hearing result from tuned amplification by an active process in the mechanoreceptive hair cells. In most vertebrates the active process stems from the active motility of hair bundles. The…

Neurons and Cognition · Quantitative Biology 2010-03-30 Tobias Reichenbach , A. J. Hudspeth

Electromotility of outer hair cells (OHCs) has been extensively studied with in vitro experiments because of its physiological significance in the cochlear amplifier, which provides the exquisite sensitivity and frequency selectivity of the…

Biological Physics · Physics 2016-12-08 Kuni H Iwasa

The extraordinary sensitivity of the mammalian inner ear has captivated scientists for decades, largely due to the crucial role played by the outer hair cells (OHCs) and their unique electromotile properties. Typically arranged in three…

Biological Physics · Physics 2023-11-16 Alessandro Altoè , Christopher A Shera

Tinnitus and hyperacusis can occur together or in isolation, with hyperacusis being associated with tinnitus much more frequently than vice versa. This striking correlation between tinnitus and hyperacusis prevalence implicates that there…

Neurons and Cognition · Quantitative Biology 2024-12-20 Holger Schulze , Achim Schilling

In response to a sound stimulus, the inner ear emits sounds called otoacoustic emissions. While the exact mechanism for the production of otoacoustic emissions is not known, active motion of individual hair cells is thought to play a role.…

Pattern Formation and Solitons · Physics 2009-11-13 K. A. Montgomery

The effectiveness of outer hair cells (OHCs) in amplifying the motion of the organ of Corti, and thereby contributing to the sensitivity of mammalian hearing, depends on the mechanical power output of these cells. Electromechanical coupling…

Biological Physics · Physics 2021-01-06 Kuni H. Iwasa

Most sounds of interest consist of complex, time-dependent admixtures of tones of diverse frequencies and variable amplitudes. To detect and process these signals, the ear employs a highly nonlinear, adaptive, real-time spectral analyzer:…

Neurons and Cognition · Quantitative Biology 2014-08-12 T. Reichenbach , A. J. Hudspeth

Whether animal or speech communication, environmental sounds, or music -- all sounds carry some information. Sound sources are embedded in acoustic environments that contain any number of additional sources that emit sounds that reach the…

Neurons and Cognition · Quantitative Biology 2019-02-21 Adam Weisser

The outer hair cell (OHC) of the organ of Corti underlies a mechanically based process that enhances hearing, termed cochlear amplification. The cell possesses a unique motor protein, prestin, which senses voltage and consequently changes…

Biological Physics · Physics 2020-01-29 Joseph Santos-Sacchi , Kuni Iwasa , Winston Tan

Non-reciprocal devices, with one-way transport properties, form a key component for isolating and controlling light in photonic systems. Optomechanical systems have emerged as a potential platform for optical non-reciprocity, due to ability…

Quantum Physics · Physics 2017-01-11 Xunnong Xu , Jacob M. Taylor

The inner ear achieves a wide dynamic range of responsiveness by mechanically amplifying weak sounds. The enormous mechanical gain reported for the mammalian cochlea, which exceeds a factor of 4,000, poses a challenge for theory. Here we…

Tissues and Organs · Quantitative Biology 2010-09-13 Tobias Reichenbach , A. J. Hudspeth

We have developed a sparse mathematical representation of speech that minimizes the number of active model neurons needed to represent typical speech sounds. The model learns several well-known acoustic features of speech such as harmonic…

Neurons and Cognition · Quantitative Biology 2012-09-25 Nicole L. Carlson , Vivienne L. Ming , Michael R. DeWeese
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