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Bulk gene expression experiments relied on aggregations of thousands of cells to measure the average expression in an organism. Advances in microfluidic and droplet sequencing now permit expression profiling in single cells. This study of…

Methodology · Statistics 2019-07-04 Andrew McDavid , Raphael Gottardo , Noah Simon , Mathias Drton

We present a method for fine-grained face manipulation. Given a face image with an arbitrary expression, our method can synthesize another arbitrary expression by the same person. This is achieved by first fitting a 3D face model and then…

Computer Vision and Pattern Recognition · Computer Science 2019-02-26 Zhenglin Geng , Chen Cao , Sergey Tulyakov

Many high-dimensional data sets suffer from hidden confounding which affects both the predictors and the response of interest. In such situations, standard regression methods or algorithms lead to biased estimates. This paper substantially…

Methodology · Statistics 2024-12-17 Cyrill Scheidegger , Zijian Guo , Peter Bühlmann

Two blind source separation methods (Independent Component Analysis and Non-negative Matrix Factorization), developed initially for signal processing in engineering, found recently a number of applications in analysis of large-scale data in…

Quantitative Methods · Quantitative Biology 2015-02-03 Andrei Zinovyev , Ulykbek Kairov , Tatiana Karpenyuk , Erlan Ramanculov

Endmember (EM) spectral variability can greatly impact the performance of standard hyperspectral image analysis algorithms. Extended parametric models have been successfully applied to account for the EM spectral variability. However, these…

Computer Vision and Pattern Recognition · Computer Science 2019-11-22 Ricardo Augusto Borsoi , Tales Imbiriba , José Carlos Moreira Bermudez

It has previously been hypothesized, and supported with some experimental evidence, that deeper representations, when well trained, tend to do a better job at disentangling the underlying factors of variation. We study the following related…

Machine Learning · Computer Science 2012-07-19 Yoshua Bengio , Grégoire Mesnil , Yann Dauphin , Salah Rifai

This work studies the problem of estimating a two-dimensional superposition of point sources or spikes from samples of their convolution with a Gaussian kernel. Our results show that minimizing a continuous counterpart of the $\ell_1$ norm…

Numerical Analysis · Mathematics 2020-08-05 Joseph McDonald , Brett Bernstein , Carlos Fernandez-Granda

We propose an approach to learn image representations that consist of disentangled factors of variation without exploiting any manual labeling or data domain knowledge. A factor of variation corresponds to an image attribute that can be…

Computer Vision and Pattern Recognition · Computer Science 2018-03-29 Qiyang Hu , Attila Szabó , Tiziano Portenier , Matthias Zwicker , Paolo Favaro

Microarrays have become extremely useful for analysing genetic phenomena, but establishing a relation between microarray analysis results (typically a list of genes) and their biological significance is often difficult. Currently, the…

Quantitative Methods · Quantitative Biology 2007-05-23 Franck Rapaport , Andrei Zinovyev , Marie Dutreix , Emmanuel Barillot , Jean-Philippe Vert

Generating faithful visualizations of human faces requires capturing both coarse and fine-level details of the face geometry and appearance. Existing methods are either data-driven, requiring an extensive corpus of data not publicly…

Computer Vision and Pattern Recognition · Computer Science 2023-05-15 Kacper Kania , Stephan J. Garbin , Andrea Tagliasacchi , Virginia Estellers , Kwang Moo Yi , Julien Valentin , Tomasz Trzciński , Marek Kowalski

We present a method for feature interpretation that makes use of recent advances in autoregressive density estimation models to invert model representations. We train generative inversion models to express a distribution over input features…

Machine Learning · Statistics 2019-01-03 Charlie Nash , Nate Kushman , Christopher K. I. Williams

We consider the problem of multivariate density deconvolution where the distribution of a random vector needs to be estimated from replicates contaminated with conditionally heteroscedastic measurement errors. We propose a conceptually…

Methodology · Statistics 2022-11-29 Arkaprava Roy , Abhra Sarkar

Hyperspectral unmixing, the process of estimating a common set of spectral bases and their corresponding composite percentages at each pixel, is an important task for hyperspectral analysis, visualization and understanding. From an…

Computer Vision and Pattern Recognition · Computer Science 2014-11-18 Feiyun Zhu , Ying Wang , Bin Fan , Gaofeng Meng , Shiming Xiang , Chunhong Pan

The reconstruction of phylogenetic trees from mixed populations has become important in the study of cancer evolution, as sequencing is often performed on bulk tumor tissue containing mixed populations of cells. Recent work has shown how to…

Data Structures and Algorithms · Computer Science 2016-04-12 Mohammed El-Kebir , Gryte Satas , Layla Oesper , Benjamin J. Raphael

This paper addresses mesh restoration problems, i.e., denoising and completion, by learning self-similarity in an unsupervised manner. For this purpose, the proposed method, which we refer to as Deep Mesh Prior, uses a graph convolutional…

Computer Vision and Pattern Recognition · Computer Science 2021-11-03 Shota Hattori , Tatsuya Yatagawa , Yutaka Ohtake , Hiromasa Suzuki

We consider the multichannel blind deconvolution problem where we observe the output of multiple channels that are all excited with the same unknown input. From these observations, we wish to estimate the impulse responses of each of the…

Numerical Analysis · Mathematics 2017-10-04 Kiryung Lee , Ning Tian , Justin Romberg

There have been a fairly of research interests in exploring the disentanglement of appearance and shape from human images. Most existing endeavours pursuit this goal by either using training images with annotations or regulating the…

Computer Vision and Pattern Recognition · Computer Science 2020-07-31 Hongtao Yang , Tong Zhang , Wenbing Huang , Xuming He , Fatih Porikli

In this work, we propose an approach for assessing sensitivity to unobserved confounding in studies with multiple outcomes. We demonstrate how prior knowledge unique to the multi-outcome setting can be leveraged to strengthen causal…

Methodology · Statistics 2023-01-26 Jiajing Zheng , Jiaxi Wu , Alexander D'Amour , Alexander Franks

Recent developments in high throughput profiling of individual neurons have spurred data driven exploration of the idea that there exist natural groupings of neurons referred to as cell types. The promise of this idea is that the immense…

Neurons and Cognition · Quantitative Biology 2019-11-14 Rohan Gala , Nathan Gouwens , Zizhen Yao , Agata Budzillo , Osnat Penn , Bosiljka Tasic , Gabe Murphy , Hongkui Zeng , Uygar Sümbül

Lexical ambiguity makes it difficult to compute various useful statistics of a corpus. A given word form might represent any of several morphological feature bundles. One can, however, use unsupervised learning (as in EM) to fit a model…

Computation and Language · Computer Science 2020-02-26 Ryan Cotterell , Christo Kirov , Sabrina J. Mielke , Jason Eisner
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