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A basic principle in the design of observational studies is to approximate the randomized experiment that would have been conducted under controlled circumstances. Now, linear regression models are commonly used to analyze observational…

Methodology · Statistics 2022-07-08 Ambarish Chattopadhyay , Jose R. Zubizarreta

Observational longitudinal data on treatments and covariates are increasingly used to investigate treatment effects, but are often subject to time-dependent confounding. Marginal structural models (MSMs), estimated using inverse probability…

Methodology · Statistics 2020-02-11 Ruth H. Keogh , Shaun R. Seaman , Jon Michael Gran , Stijn Vansteelandt

We study in detail the two main algorithms which have been considered for fitting constrained marginal models to discrete data, one based on Lagrange multipliers and the other on a regression model. We show that the updates produced by the…

Computation · Statistics 2013-05-28 Robin J. Evans , Antonio Forcina

Latent factor models that integrate data from multiple sources/studies or modalities have garnered considerable attention across various disciplines. However, existing methods predominantly focus either on multi-study integration or…

Methodology · Statistics 2025-07-15 Wei Liu , Qingzhi Zhong

A constrained multivariate linear model is a multivariate linear model with the columns of its coefficient matrix constrained to lie in a known subspace. This class of models includes those typically used to study growth curves and…

Methodology · Statistics 2021-01-05 Dennis Cook , Liliana Forzani , Lan Liu

We propose a structural equation model, which reduces to a multidimensional latent class item response theory model, for the analysis of binary item responses with non-ignorable missingness. The missingness mechanism is driven by two sets…

Methodology · Statistics 2014-10-21 Silvia Bacci , Francesco Bartolucci

Traditionally, spline or kernel approaches in combination with parametric estimation are used to infer the linear coefficient (fixed effects) in a partially linear mixed-effects model for repeated measurements. Using machine learning…

Methodology · Statistics 2023-04-03 Corinne Emmenegger , Peter Bühlmann

Multivariate longitudinal data of mixed-type are increasingly collected in many science domains. However, algorithms to cluster this kind of data remain scarce, due to the challenge to simultaneously model the within- and between-time…

Machine Learning · Statistics 2025-09-16 Francesco Amato , Julien Jacques

In practice, there often exist unobserved variables, also termed hidden variables, associated with both the response and covariates. Existing works in the literature mostly focus on linear regression with hidden variables. However, when the…

Methodology · Statistics 2025-09-03 Inbeom Lee , Yang Ning

Most data sets comprise of measurements on continuous and categorical variables. In regression and classification Statistics literature, modeling high-dimensional mixed predictors has received limited attention. In this paper we study the…

Statistics Theory · Mathematics 2021-10-26 Efstathia Bura , Liliana Forzani , Rodrigo García Arancibia , Pamela Llop , Diego Tomassi

The R package lcmm provides a series of functions to estimate statistical models based on linear mixed model theory. It includes the estimation of mixed models and latent class mixed models for Gaussian longitudinal outcomes (hlme),…

Computation · Statistics 2017-08-24 Cécile Proust-Lima , Viviane Philipps , Benoit Liquet

Many psychological theories can be operationalized as linear inequality constraints on the parameters of multinomial distributions (e.g., discrete choice analysis). These constraints can be described in two equivalent ways: Either as the…

Computation · Statistics 2019-04-23 Daniel W. Heck , Clintin P. Davis-Stober

Longitudinal brain imaging data facilitate the monitoring of structural and functional alterations in individual brains across time, offering essential understanding of dynamic neurobiological mechanisms. Such data improve sensitivity for…

Applications · Statistics 2026-02-04 Zhentao Yu , Jiaqi Ding , Guorong Wu , Quefeng Li

Many important quantities of interest are only partially identified from observable data: the data can limit them to a set of plausible values, but not uniquely determine them. This paper develops a unified framework for covariate-assisted…

Methodology · Statistics 2025-08-15 Eli Ben-Michael

We propose a method for obtaining maximum likelihood estimates in a model with continuous and binary outcomes. Combinations of left and right censored observations are also naturally modeled in this framework. The model and estimation…

Methodology · Statistics 2015-07-07 Klaus K. Holst , Esben Budtz-Jørgensen , Gitte Moos Knudsen

High-dimensional linear and nonlinear models have been extensively used to identify associations between response and explanatory variables. The variable selection problem is commonly of interest in the presence of massive and complex data.…

Methodology · Statistics 2017-08-10 Vitara Pungpapong , Min Zhang , Dabao Zhang

Simulating longitudinal data from specified marginal structural models is a crucial but challenging task for evaluating causal inference methods and informing study design. While data generation typically proceeds in a fully conditional…

Methodology · Statistics 2025-04-25 Xi Lin , Daniel de Vassimon Manela , Chase Mathis , Jens Magelund Tarp , Robin J. Evans

We consider functional linear regression models where functional outcomes are associated with scalar predictors by coefficient functions with shape constraints, such as monotonicity and convexity, that apply to sub-domains of interest. To…

Methodology · Statistics 2025-05-09 Kyunghee Han , Yeonjoo Park , Soo-Young Kim

Deep neural network (DNN) regression models are widely used in applications requiring state-of-the-art predictive accuracy. However, until recently there has been little work on accurate uncertainty quantification for predictions from such…

Methodology · Statistics 2020-09-07 Nadja Klein , David J. Nott , Michael Stanley Smith

In this paper, we consider a single-index mixed model with longitudinal data. A new set of estimating equations is proposed to estimate the single-index coefficient. The link function is estimated by using the local linear smoothing.…

Methodology · Statistics 2010-04-06 Zhen Pang , Liugen Xue