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A topic of intense current investigation pursues the question how the highly crowded environment of biological cells affects the dynamic properties of passively diffusing particles. Motivated by recent experiments we report results of…

Statistical Mechanics · Physics 2016-09-28 Surya K. Ghosh , Andrey G. Cherstvy , Denis S. Grebenkov , Ralf Metzler

We study the diffusion of a tracer particle, which moves in continuum space between a lattice of excluded volume, immobile non-inert obstacles. In particular, we analyse how the strength of the tracer-obstacle interactions and the volume…

Soft Condensed Matter · Physics 2014-12-24 Surya K. Ghosh , Andrey G. Cherstvy , Ralf Metzler

We study a two-dimensional diffusive motion of a tracer particle in restricted, crowded anisotropic geometries. The underlying medium is the same as in our previous work [J. Chem. Phys. 140, 044706 (2014)] in which standard, gaussian…

Chemical Physics · Physics 2020-03-17 Michał Cieśla , Bartłomiej Dybiec , Ewa Gudowska-Nowak , Igor Sokolov

Crowded environments modify the diffusion of macromolecules, generally slowing their movement and inducing transient anomalous subdiffusion. The presence of obstacles also modifies the kinetics and equilibrium behavior of tracers. While…

The dynamics of a tracer particle in a glassy matrix of obstacles displays slow complex transport as the free volume approaches a critical value and the void space falls apart. We investigate the emerging subdiffusive motion of the test…

Statistical Mechanics · Physics 2011-01-20 Thomas Franosch , Markus Spanner , Teresa Bauer , Gerd E. Schröder-Turk , Felix Höfling

We summarise different results on the diffusion of a tracer particle in lattice gases of hard-core particles with stochastic dynamics, which are confined to narrow channels -- single-files, comb-like structures and quasi-one-dimensional…

Statistical Mechanics · Physics 2018-11-14 O. Benichou , P. Illien , G. Oshanin , A. Sarracino , R. Voituriez

We study analytically the dynamics and the micro-structural changes of a host medium caused by a driven tracer particle moving in a confined, quiescent molecular crowding environment. Imitating typical settings of active micro-rheology…

Statistical Mechanics · Physics 2016-03-17 O. Bénichou , P. Illien , G. Oshanin , A. Sarracino , R. Voituriez

The diffusive transport of biased Brownian particles in a two-dimensional symmetric channel is investigated numerically considering both the no-flow and the reflection boundary conditions at the channel boundaries. Here, the geometrical…

Soft Condensed Matter · Physics 2019-09-10 Narender Khatri , P. S. Burada

Gradient-driven diffusion in crowded, multicomponent mixtures is a topic of high interest because of its role in biological processes such as transport in cell membranes. In partially phase-separated solutions, gradient-driven diffusion…

Soft Condensed Matter · Physics 2017-02-15 Prithviraj Nandigrami , Brandy Grove , Andrew Konya , Robin L. B. Selinger

The paper addresses the single-file diffusion in the presence of an absorbing boundary. The emphasis is on an interplay between the hard-core interparticle interaction and the absorption process. The resulting dynamics exhibits several…

Statistical Mechanics · Physics 2014-02-26 Artem Ryabov , Petr Chvosta

Many theoretical and experimental results show that solute transport in heterogeneous porous media exhibits multi-scaling behaviors. To describe such non-Fickian diffusions, this work provides a distributed order Hausdorff diffusion model…

Fluid Dynamics · Physics 2018-12-05 Yingjie Liang , Wen Chen , Wei Xu , HongGuang Sun

Tracer diffusion in crowded environments is central to many biological and soft matter systems, but quantitative frameworks for linking tracer motion to environmental structure remain limited. Here, we study the transport of rigid tracers…

Soft Condensed Matter · Physics 2026-05-07 Jinseok Lee , Tong Lin , Mengyang Gu , Yimin Luo

Macromolecular diffusion in strongly confined geometries and crowded environments is still to a large extent an open subject in soft matter physics and biology. In this paper, we employ large-scale Langevin dynamics simulations to…

Soft Condensed Matter · Physics 2020-10-07 T. P. O. Nogueira , H. O. Frota , Francesco Piazza , José Rafael Bordin

We study the transport properties of a system of active particles moving at constant speed in an heterogeneous two-dimensional space. The spatial heterogeneity is modeled by a random distribution of obstacles, which the active particles…

Biological Physics · Physics 2013-10-23 Oleksandr Chepizhko , Fernando Peruani

Transport of nanoscale objects in complex, structured environments plays a key role in a wide range of processes, from biomolecular dynamics in extracellular spaces to transport in porous materials such as filters and catalysts. While…

Diffusive transport of particles or, more generally, small objects is a ubiquitous feature of physical and chemical reaction systems. In configurations containing confining walls or constrictions transport is controlled both by the…

Statistical Mechanics · Physics 2009-01-22 P. Sekhar Burada , Peter Hanggi , Fabio Marchesoni , Gerhard Schmid , Peter Talkner

Intracellular processes often rely on the timely encounter of mobile reaction partners, including intermittently motor-driven organelles. The underlying cytoskeletal network presents a complex landscape that both directs particle movement…

Biological Physics · Physics 2025-12-17 Lizzy Teryoshin , Mario Hidalgo-Soria , Elena F. Koslover

Heterogeneous media constitute random disordered environments where transport is drastically hindered. Employing extensive molecular dynamics simulations, we investigate the spatio-temporal dynamics of tracer particles in the Lorentz model…

Statistical Mechanics · Physics 2013-02-14 Markus Spanner , Simon K. Schnyder , Felix Höfling , Thomas Voigtmann , Thomas Franosch

Diffusion of tracer particles in the cytoplasm of mammalian cells is often anomalous with a marked heterogeneity even within individual particle trajectories. Despite considerable efforts, the mechanisms behind these observations have…

Biological Physics · Physics 2020-08-05 Adal Sabri , Xinran Xu , Diego Krapf , Matthias Weiss

Living systems at the sub-cellular, cellular, and multi-cellular level are often crowded systems that contain active particles. The active motion of these particles can also propel passive particles, which typically results in enhanced…

Soft Condensed Matter · Physics 2021-05-12 Leila Abbaspour , Stefan Klumpp
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