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We study the task of retrieving relevant experiments given a query experiment. By experiment, we mean a collection of measurements from a set of `covariates' and the associated `outcomes'. While similar experiments can be retrieved by…

Machine Learning · Statistics 2014-02-20 Sohan Seth , John Shawe-Taylor , Samuel Kaski

Motivation: Public and private repositories of experimental data are growing to sizes that require dedicated methods for finding relevant data. To improve on the state of the art of keyword searches from annotations, methods for…

Machine Learning · Statistics 2016-01-08 Paul Blomstedt , Ritabrata Dutta , Sohan Seth , Alvis Brazma , Samuel Kaski

Dirichlet process (DP) mixture models provide a flexible Bayesian framework for density estimation. Unfortunately, their flexibility comes at a cost: inference in DP mixture models is computationally expensive, even when conjugate…

Machine Learning · Computer Science 2009-07-13 Hal Daumé

For large libraries of small molecules, exhaustive combinatorial chemical screens become infeasible to perform when considering a range of disease models, assay conditions, and dose ranges. Deep learning models have achieved state of the…

Generating new molecules with specified chemical and biological properties via generative models has emerged as a promising direction for drug discovery. However, existing methods require extensive training/fine-tuning with a large dataset,…

Quantitative Methods · Quantitative Biology 2023-04-25 Zichao Wang , Weili Nie , Zhuoran Qiao , Chaowei Xiao , Richard Baraniuk , Anima Anandkumar

Dense Retrieval (DR) reaches state-of-the-art results in first-stage retrieval, but little is known about the mechanisms that contribute to its success. Therefore, in this work, we conduct an interpretation study of recently proposed DR…

Information Retrieval · Computer Science 2021-11-30 Jingtao Zhan , Jiaxin Mao , Yiqun Liu , Jiafeng Guo , Min Zhang , Shaoping Ma

This paper describes a method to efficiently retrieve protein database sequences similar to a query sequence, while allowing for significant numbers of mutations. We call this method SEQR for SEQuence Retrieval. This approach increases the…

Genomics · Quantitative Biology 2018-11-05 David I. Hurwitz , Lianyi Han , Lewis Y. Geer

Within Bayesian nonparametrics, dependent Dirichlet process mixture models provide a highly flexible approach for conducting inference about the conditional density function. However, several formulations of this class make either rather…

Methodology · Statistics 2024-05-14 María Xosé Rodríguez-Álvarez , Vanda Inácio , Nadja Klein

Ranker and retriever are two important components in dense passage retrieval. The retriever typically adopts a dual-encoder model, where queries and documents are separately input into two pre-trained models, and the vectors generated by…

Information Retrieval · Computer Science 2023-12-29 Haifeng Li , Mo Hai , Dong Tang

In binary-transaction data-mining, traditional frequent itemset mining often produces results which are not straightforward to interpret. To overcome this problem, probability models are often used to produce more compact and conclusive…

Machine Learning · Computer Science 2012-09-27 Ruefei He , Jonathan Shapiro

Search and retrieval remains a major research topic in several domains, including computer graphics, computer vision, engineering design, etc. A search engine requires primarily an input search query and a database of items to search from.…

Computer Vision and Pattern Recognition · Computer Science 2022-07-05 Bharadwaj Manda , Prasad Kendre , Subhrajit Dey , Ramanathan Muthuganapathy

Code retrieval aims to provide users with desired code snippets based on users' natural language queries. With the development of deep learning technologies, adopting pre-trained models for this task has become mainstream. Considering the…

Software Engineering · Computer Science 2025-08-04 Wenchao Gu , Zongyi Lyu , Yanlin Wang , Hongyu Zhang , Cuiyun Gao , Michael R. Lyu

Motivation: With the development of droplet based systems, massive single cell transcriptome data has become available, which enables analysis of cellular and molecular processes at single cell resolution and is instrumental to…

Machine Learning · Computer Science 2018-12-27 Tiehang Duan , José P. Pinto , Xiaohui Xie

The imitation of percussive sounds via the human voice is a natural and effective tool for communicating rhythmic ideas on the fly. Thus, the automatic retrieval of drum sounds using vocal percussion can help artists prototype drum patterns…

Sound · Computer Science 2021-10-19 Alejandro Delgado , SkoT McDonald , Ning Xu , Charalampos Saitis , Mark Sandler

The dual-encoder has become the de facto architecture for dense retrieval. Typically, it computes the latent representations of the query and document independently, thus failing to fully capture the interactions between the query and…

Computation and Language · Computer Science 2023-10-31 Xingwei He , Yeyun Gong , A-Long Jin , Hang Zhang , Anlei Dong , Jian Jiao , Siu Ming Yiu , Nan Duan

Nonparametric mixture models based on the Dirichlet process are an elegant alternative to finite models when the number of underlying components is unknown, but inference in such models can be slow. Existing attempts to parallelize…

Machine Learning · Statistics 2012-12-03 Sinead A. Williamson , Avinava Dubey , Eric P. Xing

Anomaly detection is a fundamental task in machine learning and data mining, with significant applications in cybersecurity, industrial fault diagnosis, and clinical disease monitoring. Traditional methods, such as statistical modeling and…

Machine Learning · Computer Science 2025-05-09 Yi Chen

Question answering is one of the most important and difficult applications at the border of information retrieval and natural language processing, especially when we talk about complex science questions which require some form of inference…

Computation and Language · Computer Science 2019-05-08 George-Sebastian Pirtoaca , Traian Rebedea , Stefan Ruseti

The Dirichlet process (DP) is a fundamental mathematical tool for Bayesian nonparametric modeling, and is widely used in tasks such as density estimation, natural language processing, and time series modeling. Although MCMC inference…

Machine Learning · Statistics 2013-04-09 Dan Lovell , Jonathan Malmaud , Ryan P. Adams , Vikash K. Mansinghka

Effective and efficient access to relevant information is essential for disaster management. However, no retrieval model is specialized for disaster management, and existing general-domain models fail to handle the varied search intents…

Information Retrieval · Computer Science 2025-12-09 Kai Yin , Xiangjue Dong , Chengkai Liu , Allen Lin , Lingfeng Shi , Ali Mostafavi , James Caverlee
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